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Cat. No. | Product Name | Target | Signaling Pathways |
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T9107 |
NP-G2-044
|
Others | Others |
NP-G2-044 是fascin 蛋白抑制剂,具有口服活性,IC50值约为 2 μM。它可阻断肿瘤转移并增强抗肿瘤免疫应答。 | |||
T25529 |
IMM-01
|
GTPase | GPCR/G Protein |
IMM-01 是一类新型的哺乳动物透明 (mDia) 相关形式的小分子激动剂,其作用于 Rho GTPase 下游以组装肌动蛋白丝,并与微丝组织在迁移和不对称分裂过程中建立和维持细胞极性. GTP 结合的 Rho 通过破坏 DID 和 DAD 自动调节结构域之间的相互作用来激活 mDia 家族成员,从而释放 FH2 结构域以调节肌动蛋白和微管动力学。 | |||
T36853 |
Phalloidin-Tetramethylrhodamine Conjugate
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Phalloidin-retramethylrhodamine conjugate is an orange fluorescent probe (ex/em = 546/575 nm) that selectively binds to F-actin. It can be used to localize actin filaments in living or fixed cells, as well as for visualizing individual actin filaments in vitro. | |||
T41056 |
Phalloidin-TRITC
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Phalloidin-TRITC is a TRITC labeled, red fluorescence probe for F-actin . Phalloidin, bound to actin filaments, reacts covalently with amino acids Glu-llT, Met-ll9, and Met355, which are very close to the nucleotide binding site. | |||
T28782 |
Sinoporphyrin sodium
sinoporphyrin,DVDMS Free,DVDMS |
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Sinoporphyrin sodium significantly suppressed cell proliferation, promoted early apoptotic response, triggered collapse of F-actin filaments and inhibited cell migration. Sinoporphyrin sodium potentially a treatment for cancer. Sinoporphyrin sodium is als | |||
T37127 |
L-AP4 monohydrate
L-AP4 monohydrate |
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L-AP4 (L-APB) monohydrate is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively[1][2]. L-AP4 (5-30 μg, intrathecal inhection 4-5 days) significantly increases the paw withdrawal threshold in response to application of von Frey filaments in eight nerve-ligated rats in a dose-dependent manner. Intrathecal administration of different doses of L-AP4 is not associated with any evident motor dysfunctio... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T7097 |
Cytochalasin B
Phomin,细胞松弛素 B,细胞松弛素B |
Arp2/3 Complex | Cytoskeletal Signaling |
Cytochalasin B is a mycotoxin binding to the barbed end of actin filaments. It can disrupt the formation of actin polymers (Kd: 1.4-2.2 nM for F-actin). | |||
T21513 |
Cytochalasin H
(16-Benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-18-oxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl) acetate,细胞松驰素 H |
MMP | Proteases/Proteasome |
Cytochalasin H ((16-Benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-18-oxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl) acetate) 是肌动蛋白掺入细丝的有效抑制剂。 | |||
T15039 |
Cytochalasin E
|
Others | Others |
Cytochalasin E is a potent actin depolymerization agent and an epoxide containing Aspergillus-derived fungal metabolite. Cytochalasin E also inhibits angiogenesis and tumor growth. It binds and caps the barbed end of actin filaments to prevent actin elong | |||
T11712 |
Jasplakinolide
Jaspamide,NSC-613009 |
Microtubule Associated; Antifungal | Cytoskeletal Signaling; Microbiology/Virology |
Jasplakinolide(Jaspamide) 是一种来自海洋海绵 (marine sponge) 的天然环状肽,是一种有效的肌动蛋白聚合反应 (actin polymerization) 诱导剂。Jasplakinolide 具有抗真菌和抗肿瘤活性,可以稳定先前存在的肌动蛋白丝。Jasplakinolide 与鬼笔环肽竞争性结合 F-肌动蛋白,对 F-肌动蛋白的 Kd 值为 15 nM。 | |||
T35782 |
Swinholide A
MK-7684 |
Antifungal | Microbiology/Virology |
Swinholide A 是可从海绵中提取的聚酮化合物,可于肌动蛋白结合,使肌动蛋白二聚化,Kd 约为 50 nM。Swinholide A 是一种细胞毒素,可稳定肌动蛋白二聚体并切断肌动蛋白丝。Swinholide A 具有抗真菌 (antifungal)活性,可破坏细胞的肌动蛋白细胞骨架。 |