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T31513
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Dipentaerythrityl hexacaprate
dipentaerythritol hexacaprate,Dipentaerythrityl hexa C10 acid esters
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Dipentaerythrityl hexacaprate is a biochemical. |
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T19282
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Diisohexyl phthalate
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Others |
Others |
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Diisohexyl phthalate 是一种可用作增塑剂的邻苯二甲酸二烷基酯。 |
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T19319
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Ethyl docosa-4,7,10,13,16,19-hexaenoate
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Others |
Others |
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Ethyl cis-4,7,10,13,16,19-Docosahexaenoate, the ethyl ester of Docosahexaenoate (DHA), is selectively enriched in the ethyl ester fraction through the alcoholysis process involving fatty acid ethyl esters from tuna oil and lauryl alcohol. |
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T23550
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YM-750
YM 750
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Acyltransferase |
Metabolism |
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YM-750 是一种有效的酰基:胆固醇酰基转移酶(ACAT)抑制剂，IC50为0.18 μM。 |
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T50058
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1-(cyclohexylmethyl)guanidine hydroiodide
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Others |
Others |
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1-(cyclohexylmethyl)guanidine hydroiodide 是一种胍衍生物，已被用作合成多种化合物的试剂，包括肽、拟肽和其他生物活性分子，也被用作合成其他催化剂，如酰胺、酯和醚。 |
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T15176
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DSS Crosslinker
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Others |
Others |
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DSS Crosslinker 是一种不可切割的 ADC 连接剂，用于合成抗体-药物偶联物。 |
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T22399
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Phytosterols
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Others |
Others |
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Phytosterols, also called stanol esters or plant sterols, are specialized compounds found in plants that are structurally similar to cholesterol found in humans. |
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T38057
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Cholesteryl Erucate
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Cholesteryl erucate, a cholesterol ester, serves as a standard for the quantification of cholesterol esters in human meibomian gland secretions. |
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T69315
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5-TAMRA Cadaverine
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5-TAMRA cadaverine can used to modify carboxylic acid group in the presence of activators (e.g. EDC, or DCC) or activated esters (e.g. NHS esters) through a stable amide bond. |
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T36588
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9(R)-PAHSA
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9(R)-PAHSA is a stereoisomer of 9-PAHSA , an endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs). |
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T38233
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Hexanoyl-L-carnitine (chloride)
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Hexanoyl-L-carnitine is a medium-chain acylcarnitine. It has been used in the synthesis of acylcarnitine benzyl esters.1
1.Gong, X.-w., Li, J.-p., Wu, J.-f., et al.Synthesis of carnitine benzyl esters as prodrugsJ. Chem. Res.2008(6)327-330(2008) |
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T33552
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N-(Azido-PEG3)-N-bis(PEG3-NHS ester)
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N-(Azido-PEG3)-N-bis(PEG3-NHS ester) is a branched PEG derivative with a terminal azide group and two terminal NHS esters. The azide group enables PEGylation via Click Chemistry. The NHS esters can be used to label the primary amines (-NH2) of proteins, a |
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T35446
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10(R)-PAHSA
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10(R)-PAHSA is a stereoisomer of 10-PAHSA , an endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs). |
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T37918
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Prostaglandin E2 isopropyl ester
Prostaglandin E2 isopropyl ester
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Prostaglandin E2 (PGE2) isopropyl ester is a more lipophilic form of the free acid, PGE2. PG esters have enhanced lipid solubility compared to their parent compounds. They are generally hydrolyzed to the free acid by endogenous esterases upon in vivo administration, making the esters useful prodrugs. In general, the C-1 esters of PGs show greatly diminished receptor activity in vitro compared to the parent free acids. |
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T36161
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8-iso Prostaglandin E2 isopropyl ester
8-iso Prostaglandin E2 isopropyl ester
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8-iso PGE2 isopropyl ester is a more lipophilic form of the free acid, 8-iso PGE2. Prostaglandin esters have enhanced lipid solubility compared to their parent compounds. They are generally hydrolyzed to the free acid upon in vivo administration, making the esters useful prodrugs. In general, the C-1 esters of prostaglandins show greatly diminished agonist activity in vitro compared to the parent free acids. |
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T31478
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Diisononyl phthalate
Baylectrol 4200,ENJ2065,HSDB 4491,ENJ-2065,ENJ 2065
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Diisononyl phthalate (DINP), known as a plasticizer, is a phthalate. DINP is specifically a mixture of various isononyl esters of phthalic acid. |
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T21041
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Hydralazine
Apresolin,Aprezolin,Apressin
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Poly(1-decene), a thermoplastic belonging to the class of polyolefins, may be used to estimate the pour point (PP) properties of palm oil methyl esters. |
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T35447
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10(S)-PAHSA
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10(S)-PAHSA is a stereoisomer of 10-PAHSA , an endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs). |
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T68618
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S-(-)-Etomoxir
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S-(-)-Etomoxir is an inhibitor of carnitine palmitoyltransferase A (CPT1) -- a molecule required for the oxidation of long-chain acyl CoA esters. |
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T71923
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EEDQ
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EEDQ is an irreversible dopamine-receptor antagonist.EEDQ is also a highly specific reagent for carboxyl groups. It enables the coupling of acylamino acids with amino acid esters in high yield and without racemization. |
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T37399
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15(S)-HETE methyl ester
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15(S)-HETE methyl ester is a synthetic derivative of 15(S)-HETE , a major arachidonic acid metabolite from the 15-lipoxygenase pathway. Methyl esters of lipids are commonly used in formulations of nutritional supplements. |
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T76123
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Carboxylesterase
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Carboxylesterase (CESs), 即羧酸酯水解酶，广泛分布于自然界，常见于哺乳动物肝脏，常用于生化研究。Carboxylesterase 催化多种内源和外源底物的水解，包括酯、硫酯、氨基甲酸酯和酰胺，使羧酸酯水解成相应的醇和羧酸。 |
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T35723
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GRK-IN-1
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4-Amino-5-(bromomethyl)-2-methylpyrimidine is a heterocyclic building block.1,2 It has been used in the synthesis of vitamin B1 analogs and thiaminephosphoric acid esters.
|1. Abblard, J., Cronenberger, L., and Pacheco, H. Synthesis of the analogs of vitamin B1. Chim. Ther. 8(1), 98-110 (1973).|2. Leichssenring, G., and Joachim, S. The synthesis of thiaminephosphoric acid esters. Chem. Ber. 95, 767-772 (1962). |
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T37939
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N-Desethyl Bimatoprost
17-phenyl trinor Prostaglandin F2α amide
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N-Desethyl Bimatoprost (17-phenyl trinor PGF2α amide) is an F-series PG analog in which the C-1 carboxyl group has been modified to an unsubstituted amide. PG esters have been shown to have ocular hypotensive activity. PG N-ethyl amides were recently introduced as alternative PG hypotensive prodrugs. Although it has been claimed that PG amides are not converted to the free acids in vivo, studies have shown that bovine and human corneal tissue converts the amides of various PGs to the free acids ... |
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T35846
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13(R)-HODE cholesteryl ester
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13(R)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions. It remains uncertain whether the oxidized fatty acid portion of the molecule results from enzymatic lipoxygenation or from random lipid peroxidation. 13(R)-HODE cholesteryl ester can be used as a standard for analysis of chiral HODE cholesteryl esters. |
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T31671
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Erythrityl Tetranitrate
Eritrityli tetranitras,Tetranitrato de eritritilo,CHEBI:60072,Tetranitrate d'eritrityle
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Erythrityl Tetranitrate is a vasodilator with general properties similar to nitroglycerin. Like many nitrate esters, ETN acts as a vasodilator, and was the active ingredient in the original "sustained release" tablets, made in the early 50s. Ingesting ETN or prolonged skin contact can lead to absorption and what is known as a "nitro headache". |
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T35853
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9(S)-HODE cholesteryl ester
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9(S)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions. It remains uncertain whether the oxidized fatty acid portion of the molecule results from enzymatic lipoxygenation or from random lipid peroxidation. 9(S)-HODE cholesteryl ester can be used as a standard for analysis of chiral HODE cholesteryl esters. |
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T25032
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ALC67
ALC-67,ALC 67
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ALC67 has a promising anticancer activity that results in the recent discovery of a series of 3-propionyl thiazolidine-4-carboxylic acid ethyl esters as a family of novel antiproliferative agents. It is an activator of the caspase-9 involved apoptotic pat |
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T37936
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16-phenoxy tetranor Prostaglandin F2α isopropyl ester
16-phenoxy tetranor Prostaglandin F2α isopropyl ester
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Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor. Stable, lipophilic analogs of PGF2α are used to modulate luteolysis and treat glaucoma. 16-phenoxy tetranor Prostaglandin F2α isopropyl ester (16-phenoxy tetranor PGF2α isopropyl ester) is a lipophilic analog of 16-phenoxy tetranor PGF2α. Isopropyl esters of PGs serve as prodrugs, as they are efficiently hydrolyzed in certain tissues to generate the bioactive free acid. |
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T36586
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12-PAHSA
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Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are newly identified endogenous lipids regulated by fasting and high-fat feeding and associated with insulin sensitivity. Structurally, these esters are comprised of a C-16 or C-18 fatty acid (e.g., palmitoleic, palmitic, oleic, or stearic acid) linked to either a C-16 or C-18 hydroxy substituent. 12-PAHSA is a FAHFA in which palmitic acid is esterified at the 12th carbon of hydroxy stearic acid. Among the FAHFA family members, PAHSAs ar... |
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T35843
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9(R)-HODE cholesteryl ester
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9(R)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions. It remains uncertain whether the oxidized fatty acid portion of the molecule results from enzymatic lipoxygenation or from random lipid peroxidation. 9(R)-HODE cholesteryl ester can be used as a standard for analysis of chiral HODE cholesteryl esters. |
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T36590
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9-PAHSA
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Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are newly identified endogenous lipids regulated by fasting and high-fat feeding and associated with insulin sensitivity. Structurally, these esters are comprised of a C-16 or C-18 fatty acid (e.g., palmitoleic, palmitic, oleic, or stearic acid) linked to a hydroxylated C-16 or C-18 lipid. 9-PAHSA is a FAHFA in which palmitic acid is esterified to 9-hydroxy stearic acid. PAHSAs are the most abundant forms of FAHFA in serum as well as whi... |
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T36549
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CAY10486
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Acyl-Coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis. CAY10486 inhibits human ACAT-1 and ACAT-2 equally with an IC50 value of approximately 60 μM. It also inhibits copper-mediated oxidation of low density lipoproteins by about 28% at a concentration of 3 μM. |
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T38316
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ABC34
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ABC34 is an inactive control probe for JJH260 , the inhibitor of androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). ABC34 demonstrates an IC50 value greater than 25 μM for the inhibition of 9-PAHSA but is more potent in blocking the serine hydrolase ABHD6 and the palmitoyl-protein hydrolase PPT1, which are both off-targets of JJH260. |
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T35984
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CAY10485
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Acyl-coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis. CAY10485 inhibits human ACAT-1 and ACAT-2 with an IC50 values of 95 and 81 μM, respectively. It also inhibits copper-mediated oxidation of low density lipoproteins by 91% at a concentration of 2 μM. |
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T77263
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10-Methyl-9-(phenoxycarbonyl)acridinium (fluorosulfonate)
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10-Methyl-9-(phenoxycarbonyl)acridinium fluorosulfonate 为一种吖啶酯类的苯基酯，此化合物作为在中性条件下能产生化学发光的荧光染料，应用于过氧化氢的测定。 |
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T68266
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BMS-751324
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BMS-751324 是一种p38αMAPK 抑制剂。BMS-751324 含有氨基甲酰基亚甲基连接的前体，含有羟基苯基乙酸 (HPA) 衍生的酯和磷酸盐官能团。BMS-751324 在关节炎大鼠模型中有效抑制足部肿胀，并抑制 LPS 诱导的 TNFα 的生成。 |
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T35983
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Carotenoid Mixture
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Carotenoid mixture is a mixture of carotenoids that contains the antioxidative and anti-inflammatory carotenoid capsanthin and the antioxidative vitamin A precursor β-carotene , as well as additional carotenoids and carotenoid esters.1,2,3,4
1.Kim, J.S., Lee, W.M., Rhee, H.C., et al.Red paprika (Capsicum annuum L.) and its main carotenoids, capsanthin and β-carotene, prevent hydrogen peroxide-induced inhibition of gap-junction intercellular communicationChem. Biol. Interact.254146-155(2016) 2.Na... |
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T37937
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16-phenoxy tetranor Prostaglandin F2α methyl ester
16-phenoxy tetranor Prostaglandin F2α methyl ester
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Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor. Stable, lipophilic analogs of PGF2α are used to modulate luteolysis and treat glaucoma. 16-phenoxy tetranor Prostaglandin F2α (16-phenoxy tetranor PGF2α) is a metabolically stable form of PGF2α containing a 16-phenoxy group at the ω-terminus. It binds to the FP receptor on ovine luteal cells with much greater affinity (440%) than PGF2α. 16-phenoxy tetranor PGF2α methyl ester is a lipophilic a... |
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T36142
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10-PAHSA
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10-PAHSA is a newly identified endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs). It is a FAHFA in which palmitic acid is esterified to 10-hydroxy stearic acid. Among the FAHFA family members, PAHSAs are the most abundant in the adipose tissue of glucose tolerant AG4OX mice, which overexpress the Glut4 glucose transporter specifically in adipose tissue. As other FAHFAs improve glucose tolerance, stimulate insulin secretion, and have anti-... |
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T37947
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17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester
17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester
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Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity. 17-trifluoromethylphenyl trinor PGF2α is an analog of PGF2α that shares the meta-trifluoromethyl group of travoprost with the 17-phenyl trinor modification of latanoprost. It is anticipated to be a potent and selective agonist of the FP receptor, with potential applications in glaucoma and luteolysis. 17-trifluoromethylphenyl trinor PGF2α methyl ester is a lipophil... |
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T37945
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Bimatoprost methyl ester
17-phenyl trinor Prostaglandin F2α methyl ester
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Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor. Bimatoprost methyl ester is a lipophilic analog of 17-phenyl trinor PGF2α, a potent agonist for the FP receptor. 17-phenyl trinor PGF2α binds the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2α. Esters of PGs serve as prodrugs, as they are efficiently hydrolyzed in certain tissues to generate the bioactive free acid. |
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T38107
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JJH260
JJH260
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JJH260 is an N-hydroxy hydantoin carbamate that inhibits androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). It blocks the hydrolysis of 9-PAHSA with an IC50 value of 0.57 μM. JJH260 also inhibits the novel FAHFA hydrolase androgen-dependent TFPI-regulating protein (ADTRP; IC50 = 8.5 μM), as well as the serine hydrolase ABHD6 and the lysophospholipases LYPLA1 and LYPLA2. JJH260 inhibits the FAHFA hydrolase activity of LNCaP and T cell lysa... |
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T36567
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DPPP
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DPPP is a probe that reacts stoichiometrically with hydroperoxides to yield the fluorescent molecule diphenyl-1-pyrenylphosphine oxide (DPPP-O). Plasma levels of lipid hydroperoxides of phosphatidylcholine, phosphatidylethanolamine, triglycerides, and cholesteryl esters have been measured by HPLC with a post column detection system using DPPP. DPPP has also been used as a fluorescent probe for the detection of low density lipoprotein and cellular oxidation. Fluorescence of DPPP-O can be monitor ... |
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T38115
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Fluprostenol serinol amide
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2-arachidonyl glycerol (2-AG) exhibits cannabinoid (CB) agonist activity at the CB1 receptor, is an important endogenous monoglyceride species, and is thus considered to be the natural ligand for the CB1 receptor. 2-AG can also be metabolized by cyclooxygenase-2 and specific prostaglandin H2 (PGH2) isomerases to form PG 2-glyceryl esters. Fluprostenol serinol amide (Flu-SA) is a stable analog of PGF2α 2-glyceryl ester that has much greater stability. The biological activity of Flu-SA has not yet... |
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T36731
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Cholesteryl Heptadecanoate
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Cholesteryl heptadecanoate is a cholesterol ester (CE) formed by the condensation of cholesterol with heptadecanoic acid, a C-17 saturated fatty acid that does not occur in any natural animal or vegetable fat at high concentrations. As such, it is commonly used as an internal standard for the quantification of cholesterol esters by GC- or LC-mass spectrometry. CEs are major constituents of lipoprotein particles carried in blood and accumulate in the fatty acid lesions of atherosclerotic plaques.... |
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T35893
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rac-1,2-bis-Palmitoyl-3-chloropropanediol
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rac-1,2-bis-Palmitoyl-3-chloropropanediol is a 3-monochloropropane-1,2-diol (3-MCPD) ester.1It has been found as a contaminant in edible olive oils, with the lowest and highest concentrations in extra virgin and olive pomace oils, respectively.rac-1,2-bis-Palmitoyl-3-chloropropanediol has also been found in cottonseed and palm oils, as well as in shortening.2It induces renal tubular necrosis and a decrease in spermatids, but no gross pathological changes, in mice.3
1.Hung, W.-C., Peng, G.-J., Ts... |
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T76130
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Acetylcholinesterase
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Acetylcholinesterase(ACHE; EC 3.1.1.7), 即乙酰胆碱酯酶，是一种胆碱能酶，主要存在于神经肌肉接头和胆碱能类型的化学突触中，常用于生化研究。Acetylcholinesterase 可以催化乙酰胆碱和其他一些充当神经递质的胆碱酯分解或水解为乙酸和胆碱。Acetylcholinesterase 主要作用是终止突触之间的神经元传递和信号传导，以防止 ACh 扩散和附近受体的激活。 |
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T37627
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Latanoprost ethyl amide
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Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity. Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue con... |
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T36691
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Erythromycin 2'-Propionate
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Erythromycin 2'-propionate is a macrolide antibiotic and an esterified form of erythromycin .1It is active againstS. aureuswhen used at a concentration of 1 μg/ml. Erythromycin 2'-propionate (1 mM) inhibits protein synthesis in a cell-free assay.
1.Tardrew, P.L., Mao, J.C.H., and Kenney, D.Antibacterial activity of 2'-esters of erythromycinAppl. Microbiol.18(2)159-165(1969) |
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