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Cat. No. | Product Name | Target | Signaling Pathways |
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T40495 |
Elastase from porcine pancreas
弹性蛋白酶,EC 3.2.1.35 |
Others | Others |
Elastase from porcine pancreas 由 240 个氨基酸残基组成,是一种丝氨酸蛋白酶,可以水解蛋白质和多肽。它可诱发仓鼠气肿。 | |||
T4983 |
Isoetharine mesylate salt
Isoetarine mesilate,异丙肾上腺素甲磺酸盐 |
Others; Adrenergic Receptor | GPCR/G Protein; Neuroscience; Others |
Isoetharine mesylate salt (Isoetarine mesilate) 是一种 β-肾上腺素能受体激动剂。它还是能够上调 CYP450 表达的孕烷 X 受体(PXR) 激活剂。 | |||
T15543 |
IA-Alkyne
N-Hex-5-ynyl-2-iodo-acetamide,Iodoacetamide-alkyne |
TRP/TRPV Channel | Membrane transporter/Ion channel |
IA-Alkyne (Iodoacetamide-alkyne) 是TRP 通道 (TRPC) 的激动剂,有用于呼吸道感染相关疾病研究的潜力。IA-Alkyne 可以用于开发同位素标记的探针,在定量的半胱氨酸反应分析 (cysteine-reactivity)有应用的价值。 | |||
T6547 |
Ipratropium Bromide
Sch 1000,异丙托溴铵,Itrop,Atrovent |
AChR | Neuroscience |
Ipratropium Bromide (Sch 1000) 是毒蕈碱的受体的拮抗剂,可用于 COPD 和哮喘等研究,对 M1、M2 和 M3 受体的结合的IC50值分别为 2.9、2 和 1.7 nM。 | |||
T2555 |
Aclidinium bromide
LAS 34273,LAS-W 330,阿地溴铵 |
AChR | Neuroscience |
Aclidinium bromide (LAS-W 330) 是长效可吸入型的毒蕈碱拮抗剂,有用于慢性阻塞性肺病 (COPD) 的研究潜力。 | |||
T68178 | Neltenexine HCl | ||
Neltenexine HCl is the salt form of Neltenexine free base, an elastase inhibitor that may be useful for preventing pulmonary emphysema. | |||
T68179 | Neltenexine | ||
Neltenexine is an elastase inhibitor that may be useful for preventing pulmonary emphysema. | |||
T60071 |
PF 00356231
|
MMP | Proteases/Proteasome |
PF 00356231 是一种特异性抑制剂 MMP-12,可用于治疗肺气肿和慢性阻塞性肺病 (COPD) 的研究。 | |||
T13899 |
Spirofylline
|
Others | Others |
Spirofylline is an agent of bronchodilator, has the potential for asthma and bronchitis and emphysema treatment. | |||
T4983L |
Isoetharine
Isoetarine,Bronkosol,Bronkometer,Etyprenalinum |
||
Isoetharine is a selective agonist of β2-adrenergic receptor used as a bronchodilator for emphysema, bronchitis, and asthma. | |||
T75330 | Lysozyme chloride | ||
Lysozyme chloride 是一种杀菌酶,它能裂解革兰氏阳性细菌 (bacteria)。Lysozyme chloride 还可用于HIV 感染和肺气肿的研究。 | |||
T27540 |
Hexoprenaline Sulfate
ST-1512,Argocian,Gynipral |
||
Hexoprenaline Sulfate is a selective beta2-adrenoreceptor agonist. Hexoprenaline Sulfate is active in man as a bronchodilator by the oral or intravenous routes and by inhalation. Hexoprenaline Sulfate is indicated for use in the treatment of bronchospasm | |||
T70097 | Acefylline piperazine | ||
Acefylline piperazine is a stimulant drug of the xanthine chemical class. It acts as an adenosine receptor antagonist. Acephylline piperazine is a theophylline derivative with a direct bronchodilator action. It has the advantages over theophylline in being far less toxic and producing minimal gastric irritation. It is indicated for the treatment of asthma, emphysema, acute and chronic bronchitis associated with bronchospasm.Acefylline relaxes smooth muscles, relieves bronchospasm & has a stimula... | |||
T21989 |
SSR 69071
|
||
SSR69071 是一种有效的,具有口服活性的选择性中性粒细胞弹性蛋白酶 (neutrophil elastase) 抑制剂。SSR69071 对人弹性蛋白酶 (Ki=0.0168 nM) 的亲和力高于对大鼠 (Ki=3 nM)、小鼠 (Ki=1.8 nM) 和兔 (Ki=58 nM) 弹性蛋白酶。SSR69071 减少缺血再灌注损伤后的心肌梗死面积。SSR69071 还具有治疗慢性阻塞性肺病、哮喘、肺气肿、囊性纤维化和多种炎症性疾病的潜力。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0892 |
Diphylline
二羟丙茶碱,Dyphylline,Diprophylline |
PDE; Adenosine Receptor | GPCR/G Protein; Metabolism; Neuroscience |
Diphylline (Diprophylline) 是一种A1/A2腺苷受体拮抗剂,也是环状核苷酸磷酸二酯酶抑制剂。它是一种黄嘌呤衍生物,具有支气管扩张和血管扩张作用,有用于治疗慢性支气管炎和肺气肿的潜力。 |