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29

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8615	ISOTHIAZOLINE 1,1-DIOXIDE 异噻唑烷 1,1-二氧化物,isothiazolidine 1,1-dioxide	Others	Others
	ISOTHIAZOLINE 1,1-DIOXIDE (isothiazolidine 1,1-dioxide) 是一种反应物，用于合成口服生物可利用的 hebatits B caspid 抑制剂，并用于制备隐花色素抑制剂作为抗糖尿病药物。
T28754	Sepin-1 Sepin 1,Sepin1,2H-Benzimidazole, 2,2-dimethyl-5-nitro-, 1,3-dioxide	Others	Others
	Sepin-1 是一种分离酶的非竞争性抑制剂，IC50 为 14.8 µM。 Sepin-1可以通过抑制细胞增殖和诱导细胞凋亡来抑制小鼠和人类癌细胞系乳腺癌异种移植瘤的生长。
T16950	Sudoxicam 舒多昔康,4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide	COX	Immunology/Inflammation; Neuroscience
	Sudoxicam (4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide) 是一种可逆的 COX 拮抗剂，具有抗炎、抗水肿和解热特性。
T30743	Carbon dioxide reduction factor Methanofuran,Cdr factor
	Carbon dioxide reduction factor is a coenzyme of methanogenesis from carbon dioxide.
T32615	L-Cystine S,S-dioxide Cystinedisulfoxide
	L-Cystine S,S-dioxide is a metabolite of L-Cystine.
T34857	Thiophene-3-ol, 2,3-dihydro-, sulfate, 1,1-dioxide
	Thiophene-3-ol, 2,3-dihydro-, sulfate, 1,1-dioxide is a bioactive chemical.
T60224	1H-Pyrrolo[2,1-c][1,2,4]benzothiadiazine, 2,3,3a,4-tetrahydro-, 5,5-dioxide, (3aR)-	GluR	Neuroscience
	1H-Pyrrolo[2,1-c][1,2,4]benzothiadiazine, 2,3,3a,4-tetrahydro-, 5,5-dioxide, (3aR)-是S 18986的低活性异构体。S 18986是一种AMPA 受体阳性调节剂，EC2（浓度为AMPA 诱导电流强度的两倍）为35μM。
T73955	Potassium clavulanate mixture with silicon dioxide (1:1)
	Potassium clavulanate mixture with silicon dioxide (1:1)为Potassium clavulanate与Silicon dioxide按1:1比例混合而成的化合物。
T65943	Methyl 2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide
	Methyl 2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T65943。
T65688	Ethyl 4-hydroxy-2-methyl-2H-benzo[e][1,2]thiazine-3-carboxylate 1,1-dioxide
	Ethyl 4-hydroxy-2-methyl-2H-benzo[e][1,2]thiazine-3-carboxylate 1,1-dioxide 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65688，CAS号为 24683-26-9。
T65296	Methyl 4-hydroxy-2-methyl-2H-thieno[2,3-e][1,2]thiazine-3-carboxylate 1,1-dioxide
	Methyl 4-hydroxy-2-methyl-2H-thieno[2,3-e][1,2]thiazine-3-carboxylate 1,1-dioxide 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65296，CAS号为 59804-25-0。
T65610	(S)-4-Hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide
	(S)-4-Hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65610，CAS号为 154127-42-1。
T67423	Tazobactam diphenylmethyl ester
	Benzhydryl (2S,3S,5R)-3-((1H-1,2,3-triazol-1-yl)methyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T67423。
T23478	Trometamol hydrochloride TRIS hydrochloride,三(羟甲基)氨基甲烷盐酸盐	Others	Others
	Trometamol hydrochloride (TRIS hydrochloride) 是低毒性的生物惰性氨基醇，可以在体内、外缓冲二氧化碳和酸，能用于生理范围内控制 pH 值。
T2134	Dorzolamide hydrochloride MK507 hydrochloride,L671152 hydrochloride,MK-507 (L-671152) HCl,盐酸多佐胺,Dorzolamide HCl	Carbonic Anhydrase	Metabolism
	Dorzolamide hydrochloride (MK507 hydrochloride) 是一种碳酸酐酶carbonic anhydrase II 抑制剂，能够抑制红细胞CA-II(IC50:0.18 nM) 和CA-I(IC50:600 nM) 。
T39182	1-Bromo-1,1-dichloroacetone
	1-Bromo-1,1-dichloroacetone, classified as a chlorine dioxide disinfection byproduct (DBP), is present in drinking water.
T10716	CCR7 Ligand 1 CCR7-Cmp2105	Others	Others
	CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. CCR7 Ligand 1, thiadiazole-dioxide ligan, suppresses arrestin binding in response to activation by CCL19 with an IC50 of 7.3 μM
T38945	Carboxy-PTIO
	Carboxy-PTIO is a highly effective nitric oxide (NO) scavenger known for its rapid reaction rate with NO, resulting in the formation of nitric dioxide (NO2). Its direct scavenging action against NO plays a crucial role in preventing hypotension and endotoxic shock, particularly in lipopolysaccharide-stimulated rat models.
T77233	L-Tartaric acid sodium hydrate
	L-Tartaric acid (L-(+)-Tartaric acid) sodium hydrate，D-酒石酸的对映异构体，是一种存在于多种植物（例如葡萄）中的白色结晶二羧酸，也是葡萄酒中的主要有机酸之一。此化合物能与碳酸氢钠反应生成二氧化碳，用作面粉膨松剂，同时也是食品添加剂。
T76143	Pyruvate oxidase
	Pyruvate oxidase(PoxB) 是一种焦磷酸硫胺素依赖型的氧化酶，可以催化丙酮酸氧化脱羧生成乙酰磷酸、二氧化碳和水。Pyruvate oxidase 是细菌代谢中的一种重要酶，常用于生化研究。
T75327	Magnesium silicate
	Magnesium silicate (Activated magnesium silicate) 是由氧化镁 (MgO) 和二氧化硅 (SiO2) 组成的化合物。该化合物在制备抗酸剂和抗溃疡剂中应用，同时也作为除臭剂、脱色剂和抗真菌剂使用。
T78971	AMPA receptor modulator-4	iGluR	Membrane transporter/Ion channel; Neuroscience
	AMPA receptor modulator-4 是一种口服有效的 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (BTD) 类 AMPA 受体正变构调节剂 (AMPAR PAM)。该化合物能穿透血脑屏障，能够增强小鼠的认知能力并改善其工作记忆。
T36512	PTIO	NO Synthase	Immunology/Inflammation
	PTIO 是一种特定的 NO 清除剂。 PTIO 与一氧化氮反应形成二氧化氮和相应的亚氨基氮氧化物。 PTIO 可用于检查一氧化氮合酶抑制活性。
T76149	Formate dehydrogenase
	Formate dehydrogenase 是一种普遍存在于原核生物和真核生物中的酶，能催化甲酸盐可逆氧化为二氧化碳。根据其金属含量、结构及催化策略，可将Formate dehydrogenase 分为非金属类和含金属类两种，广泛应用于生化研究领域。
T76013	Carbonic anhydrase
	Carbonic anhydrase 是原核生物和真核生物中普遍存在的含锌金属酶。Carbonic anhydrase 可以催化二氧化碳可逆地转化为碳酸氢盐和质子。Carbonic anhydrase 可用于癌症、青光眼、肥胖症和癫痫症的研究。
T73614	Tyrosine decarboxylase
	Tyrosine decarboxylase (TDC; TyrDC)，即酪氨酸脱羧酶，广泛存在于植物、昆虫和不同微生物中，常用于生化研究。Tyrosine decarboxylase 是一种5'-磷酸吡哆醛 (PLP) 依赖性脱羧酶，可以催化酪氨酸中羧基的去除，产生酪胺和二氧化碳。
T19902	C.I. 15670 NSC-12453,NSC12453,NSC 12453
	C.I. 15670是一种颜料，为红紫色粉末。可用于油墨、染料激光器、乙烯基聚合物制造、纺织品铁、钙、铝、钽的测定、工业水中硬度的监测、饮用水中二氧化氯的测量、降血糖剂、核荧光染料等。
T68738	(±)-γ-Tocopherol
	(±)-γ-Tocopherol is a form of vitamin E with antioxidant and anti-inflammatory properties. It traps and detoxifies reactive nitrogen oxide species, including nitrogen dioxide, in cell-free assays. It also reduces the synthesis of prostaglandin E2 (PGE2) induced by LPS in RAW 264.7 macrophages and by IL-1β in A549 cells. (±)-γ-Tocopherol inhibits LPS-induced nitrite release and inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells and reduces COX-2 activity in A549 cells pretreated...
T37270	9(E),11(E)-12-nitro Conjugated Linoleic Acid
	9(E),11(E)-12-nitro Conjugated linoleic acid (9(E),11(E)-12-nitro CLA) is a nitrated fatty acid. It is formed from 9(Z),11(E)-CLA upon exposure to acidified nitrite, peroxynitrite, gaseous nitrogen dioxide, or a combination of myeloperoxidase, hydrogen peroxide, and nitrite.1It is also formed in LPS-stimulated RAW 264.7 macrophages, an effect that can be reduced by the nitric oxide synthase (NOS) inhibitor L-NAME .29(E),11(E)-12-nitro CLA has been found in human plasma. 1.Woodcock, S.R., Salvato...

化合物

ISOTHIAZOLINE 1,1-DIOXIDE

Cat.No: T8615

Synonym: 异噻唑烷 1,1-二氧化物,isothiazolidine 1,1-dioxide

Target: Others

Cat.No: T28754

Synonym: Sepin 1,Sepin1,2H-Benzimidazole, 2,2-dimethyl-5-nitro-, 1,3-dioxide

Target: Others

Cat.No: T16950

Synonym: 舒多昔康,4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide

Target: COX

Carbon dioxide reduction factor

Cat.No: T30743

Synonym: Methanofuran,Cdr factor

L-Cystine S,S-dioxide

Cat.No: T32615

Synonym: Cystinedisulfoxide

Thiophene-3-ol, 2,3-dihydro-, sulfate, 1,1-dioxide

Cat.No: T34857

1H-Pyrrolo[2,1-c][1,2,4]benzothiadiazine, 2,3,3a,4-tetrahydro-, 5,5-dioxide, (3aR)-

Cat.No: T60224

Target: GluR

Potassium clavulanate mixture with silicon dioxide (1:1)

Cat.No: T73955

Methyl 2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide

Cat.No: T65943

Ethyl 4-hydroxy-2-methyl-2H-benzo[e][1,2]thiazine-3-carboxylate 1,1-dioxide

Cat.No: T65688

Methyl 4-hydroxy-2-methyl-2H-thieno[2,3-e][1,2]thiazine-3-carboxylate 1,1-dioxide

Cat.No: T65296

(S)-4-Hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide

Cat.No: T65610

Tazobactam diphenylmethyl ester

Cat.No: T67423

Trometamol hydrochloride

Cat.No: T23478

Synonym: TRIS hydrochloride,三(羟甲基)氨基甲烷盐酸盐

Target: Others

Dorzolamide hydrochloride

Cat.No: T2134

Synonym: MK507 hydrochloride,L671152 hydrochloride,MK-507 (L-671152) HCl,盐酸多佐胺,Dorzolamide HCl

Target: Carbonic Anhydrase

1-Bromo-1,1-dichloroacetone

Cat.No: T39182

Cat.No: T10716

Synonym: CCR7-Cmp2105

Target: Others

Cat.No: T38945

L-Tartaric acid sodium hydrate

Cat.No: T77233

Pyruvate oxidase

Cat.No: T76143

Magnesium silicate

Cat.No: T75327

AMPA receptor modulator-4

Cat.No: T78971

Target: iGluR

Cat.No: T36512

Target: NO Synthase

Formate dehydrogenase

Cat.No: T76149

Carbonic anhydrase

Cat.No: T76013

Tyrosine decarboxylase

Cat.No: T73614

Cat.No: T19902

Synonym: NSC-12453,NSC12453,NSC 12453

(±)-γ-Tocopherol

Cat.No: T68738

9(E),11(E)-12-nitro Conjugated Linoleic Acid

Cat.No: T37270

Cat. No.	Product Name	Target	Signaling Pathways
T34642	Silicon dioxide
	Silicon dioxide is a transparent, tasteless crystals found in nature as agate, amethyst, chalcedony, cristobalite, flint, sand, QUARTZ, and tridymite. The compound is insoluble in water or acids except hydrofluoric acid.
TN6754	1-Nonadecanol	Others	Others
	1-Nonadecanol 是一种 Heracleum thomsonii 的超临界二氧化碳精油的成分，也是 Neotinea ustulata 的重要香气化合物。
T5803	D(-)-Tartaric acid	Others	Others
	D(-)-Tartaric acid 存在于许多植物中，特别是罗望子和葡萄，口服后通过与碳酸氢钠相互作用产生二氧化碳。二氧化碳会延伸胃部并在双造影射线照相期间提供负造影剂。

天然产物

Silicon dioxide

Cat.No: T34642

Cat.No: TN6754

Target: Others

D(-)-Tartaric acid

Cat.No: T5803

Target: Others

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