Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. CCR7 Ligand 1, thiadiazole-dioxide ligan, suppresses arrestin binding in response to activation by CCL19 with an IC50 of 7.3 μM.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 3,290 | 5日内发货 | ||
5 mg | ¥ 5,390 | 5日内发货 | ||
25 mg | ¥ 18,900 | 10-14周 | ||
50 mg | ¥ 24,600 | 10-14周 | ||
100 mg | ¥ 35,500 | 10-14周 |
产品描述 | CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. CCR7 Ligand 1, thiadiazole-dioxide ligan, suppresses arrestin binding in response to activation by CCL19 with an IC50 of 7.3 μM. |
靶点活性 | CCR7 (human):3 nM (kd) |
体外活性 | CCR7 Ligand 1 (CCR7-Cmp2105) binds to a pocket at the intracellular part of CCR7 between the ends of TM1, TM2, TM3, and TM6 and the loop between TM7 and H8[1]. CCR7 Ligand 1 allosterically inhibits binding of the native chemokine CCL19 ligand in scintillation proximity assays (bottom) with an IC50 of 35 nM[1]. CCR7 Ligand 1 (20, 40, 60, 80, 100 μM) has dose-dependent thermo-stabilizing effect on CCR7[1]. |
别名 | CCR7-Cmp2105 |
分子量 | 475.56 |
分子式 | C22H29N5O5S |
CAS No. | 681514-83-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 12.5 mg/mL (26.28 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.1028 mL | 10.5139 mL | 21.0278 mL | 52.5696 mL |
5 mM | 0.4206 mL | 2.1028 mL | 4.2056 mL | 10.5139 mL | |
10 mM | 0.2103 mL | 1.0514 mL | 2.1028 mL | 5.257 mL | |
20 mM | 0.1051 mL | 0.5257 mL | 1.0514 mL | 2.6285 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
CCR7 Ligand 1 681514-83-0 Others CCR7-Cmp2105 CCR-7 Ligand 1 Inhibitor inhibitor inhibit