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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T9911	Tocilizumab	Interleukin	Immunology/Inflammation
	Tocilizumab 是抗人白细胞介素-6 受体 (IL-6R) 的中和抗体，能够阻碍 IL-6 与 IL-6R 的结合，进而抑制经典和反式信号。它可用于研究类风湿性关节炎，对重症 COVID-19 冠状病毒病方面的研究具有显著效果。
T0134	Imiquimod 咪喹莫特,R 837,S-26308	SARS-CoV; TLR; Autophagy; HSV	Autophagy; Immunology/Inflammation; Microbiology/Virology
	Imiquimod (R 837) 是一种免疫反应修饰剂，可作为 toll 样受体7 激动剂。它有抗病毒和抗肿瘤作用，可研究外生殖器、肛周疣、癌症和 COVID-19。
T1406	Amantadine hydrochloride 盐酸金刚烷胺,1-adamantanamine HCl,1-Adamantanamine hydrochloride,Symmetrel,CI-719,Amantadine HCl,1-Adamantylamine hydrochloride	Dopamine Receptor; Influenza Virus	GPCR/G Protein; Microbiology/Virology; Neuroscience
	Amantadine hydrochloride (CI-719) 是一种抗病毒药物，用于预防或对症治疗甲型流感和帕金森病。它阻断质子流通过 M2 离子通道，从而阻止病毒 RNA 释放到感染细胞的细胞质中。
T72364	SARS-CoV-2 3CLpro-IN-5	SARS-CoV	Microbiology/Virology
	SARS-CoV-2 3CLpro-IN-5 是一种针对 3C样蛋白酶3CLpro 的共价抑制剂，其抑制活性的 IC50 为 3.8 nM。该化合物的口服生物利用度（BA）为 9.0%，可用于 COVID-19 研究。
T63660	Anti-inflammatory agent 19
	Anti-inflammatory agent 19 能够抑制 NO (IC50: 36.00 μM)。Anti-inflammatory agent 19 对 HMGB1 诱导的后期炎症反应表现出抑制作用。Anti-inflammatory agent 19 能够用于研究后期炎症疾病，如冠状病毒病 (COVID-19)、败血症等。
T63473	Anti-inflammatory agent 18
	Anti-inflammatory agent 18 能够抑制NO 的活性 (IC50: 15.94 μM)，对 HMGB1 诱导的后期炎症反应具有抑制作用，能够用于研究后期炎症疾病，如冠状病毒病 (COVID-19)、败血症等。
T69035	Camostat free base
	Camostat, also known as FOY 305, is a serine protease inhibitor. Camostat is used in the treatment of some forms of cancer and is also effective against some viral infections, as well as inhibiting fibrosis in liver or kidney disease or pancreatitis. It is an inhibitor of the enzyme transmembrane protease, serine 2 (TMPRSS2). Inhibition of TMPRSS2 partially blocked infection by SARS-CoV and Human coronavirus NL63 in HeLa cell cultures. In vitro study showed that camostat significantly reduces...
T72370	SARS-CoV-2 3CLpro-IN-6
	SARS-CoV-2 3CLpro-IN-6 是 SARS-CoV-2 3CL 蛋白酶的可逆共价抑制剂。SARS-CoV-2 3CLpro-IN-6 对 SARS-CoV-2 3CLpro 具有强效抑制活性，IC50值为 4.9 μM。SARS-CoV-2 3CLpro-IN-6 可用于 COVID-19 的研究。

化合物

Tocilizumab

Cat.No: T9911

Synonym:

Target: Interleukin

Imiquimod

Cat.No: T0134

Synonym: 咪喹莫特,R 837,S-26308

Target: SARS-CoV, TLR, Autophagy, HSV

Amantadine hydrochloride

Cat.No: T1406

Synonym: 盐酸金刚烷胺,1-adamantanamine HCl,1-Adamantanamine hydrochloride,Symmetrel,CI-719,Amantadine HCl,1-Adamantylamine hydrochloride

Target: Dopamine Receptor, Influenza Virus

SARS-CoV-2 3CLpro-IN-5

Cat.No: T72364

Synonym:

Target: SARS-CoV

Anti-inflammatory agent 19

Cat.No: T63660

Synonym:

Target:

Anti-inflammatory agent 18

SARS-CoV-2 3CLpro-IN-6

Cat.No: T72370

Synonym:

Target:

Cat. No.	Product Name	Target	Signaling Pathways
T7060	Amantadine 1-Aminoadamantane,1-金刚烷胺,金刚烷胺,1-Adamantanamine,1-Adamantylamine	Others	Others
	Amantadine (1-Aminoadamantane) 是抗病毒药物，也是是 NMDA 型谷氨酸受体的弱拮抗剂，能促进高多巴胺的释放，并阻断多巴胺的再摄取。