43
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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T16366 |
NVR 3-778
|
HBV | Microbiology/Virology |
NVR 3-778 是一种 SBA 类的口服有效HBV CAM 衣壳组装调制剂,具有抗 HBV 活性。 | |||
T11465 |
Lenacapavir
GS-6207 |
Others; HIV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
Lenacapavir (GS-6207) 是一种有效的靶向衣壳的 HIV 复制抑制剂。 Lenacapavir 在 MT-4 细胞中显示出抗 HIV 活性,EC50 为 100 pM。 | |||
T16500 |
PF-3450074
PF-74 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
PF-3450074 (PF-74)是 HIV-1 衣壳蛋白的特异性抑制剂,可广谱抑制 HIV 分离株。它在 HIV-1 感染的早期阶段起作用,通过与 CPSF6 和 NUP153 的结合直接竞争来抑制病毒复制,并阻断病毒生命周期的脱膜,组装和逆转录步骤。 | |||
T9054 |
RO6889678
|
HBV | Microbiology/Virology |
RO6889678 是高效的 HBV 衣壳结构抑制剂,其吸收、分布、代谢和排泄特征较为复杂。它可通过 CYP3A4 介导的氧化作用进行代谢,以及通过 UDP-葡萄糖醛酸基转移酶 UGT1A3 和 UGT1A1 介导的直接葡萄糖醛酸化作用进行代谢。它是一种诱导剂,可作用于人肝细胞中 CYP3A4 和共调节蛋白。 | |||
T6439 |
Cetylpyridinium Chloride
西吡氯铵,Cetamium,Pristacin,Hexadecylpyridinium Chloride |
Others; HBV; Antibacterial | Microbiology/Virology; Others |
Cetylpyridinium Chloride (Hexadecylpyridinium Chloride) 是阳离子季铵,是一种广谱抗菌剂。它有效抑制 HBV 衣壳装配,IC50为 2.5 μM。它被用于杀虫剂和各种漱口水以及其他个人护理产品中。 | |||
T4536 |
Pleconaril
VP 63843,Win 63843,Picovir,普可那利 |
Virus Protease; Antiviral | Immunology/Inflammation; Microbiology/Virology |
Pleconaril (VP 63843) 是一种有潜力研究肠病毒的衣壳抑制剂,, 它可有效抑制复制, IC50值为 50 nM。 | |||
T27221 |
DVR-01
3-(azepan-1-ylsulfonyl)-N-benzyl-4-chlorobenzamide |
HBV | Microbiology/Virology |
DVR-01 是一种 HBV 衣壳抑制剂,可用于治疗乙型肝炎病毒 (HBV) 感染和相关疾病的研究。 | |||
TP1739L |
HEX3 acetate(688805-40-5 free base)
|
Others | Others |
HEX3 acetate(688805-40-5 free base) 是腺病毒六邻体的一个片段。 Hexon 是腺病毒的主要衣壳蛋白,由三个相同的多肽链组成。 | |||
T20000 |
I-XW-053
4-(4,5-二苯基-1H-咪唑-2-基)苯甲酸 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
I-XW-053 是一种针对衣壳的 HIV-1 复制抑制剂,使用基于混合结构的方法以微摩尔亲和力阻断 CA N 末端结构域之间的界面(NTD-NTD 界面)。 | |||
T4492 |
pocapavir
SCH-48973,V-073 |
Virus Protease; Antiviral | Immunology/Inflammation; Microbiology/Virology |
Pocapavir (SCH-48973) 是一种具有口服活性的研究性肠道病毒衣壳抑制剂,可防止病毒粒子进入细胞后脱壳。 | |||
TQ0017 |
AB-423
|
HBV | Microbiology/Virology |
AB-423 是一种 HBV 衣壳组装抑制剂,抑制 HBV 复制。在细胞中,EC50/EC90值分别为 0.08-0.27 μM/0.33-1.32 μM。 | |||
T1750 |
Pirodavir
R77975,吡罗达韦 |
Virus Protease; Antiviral | Immunology/Inflammation; Microbiology/Virology |
Pirodavir (R77975) 是一种广谱抗小核糖核酸病毒抑制剂,有效抑制人鼻病毒衣壳的结合。 | |||
T4475 |
JNJ-632
|
HBV | Microbiology/Virology |
JNJ-632 是一种乙型肝炎病毒衣壳组装调节剂。 | |||
T11409 |
GLP-26
|
HBV | Microbiology/Virology |
GLP-26 是一种HBV 衣壳组装调节剂,抑制 Hep AD38 系统中的 HBV DNA 复制,IC50值为3 nM。 在 1 μM 时,使 cccDNA 降低> 90%。它破坏前基因组 RNA 的衣壳化,导致核衣壳解体,并减少 cccDNA 库。 | |||
T28860 |
ST-148
ST148 |
||
ST-148 is a potent inhibitor for Dengue virus capsid. ST-148-enhanced capsid protein self-interaction perturbs assembly and disassembly of DV nucleocapsids, probably by inducing structural rigidity. | |||
T10446 |
BA-53038B
|
Others | Others |
BA-53038B is an HBV core protein allosteric modulator (CpAM), binding to the HAP pocket and modulating HBV capsid assembly in a distinct manner (EC50: 3.32 μM). | |||
T10658 |
CA inhibitor 1
GS-6207 analog |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
CA inhibitor 1 (GS-6207 analog) is a potent inhibitor of the HIV capsid. | |||
T71799 |
CAP-1
|
||
CAP-1 is an inhibitor of HIV-1 capsid formation. | |||
T62467 | HBV-IN-18 | ||
HBV-IN-18 (Compound 3) 是一种 HBV 衣壳组装调节剂 (CpAM) (EC50: 2790 nM)。 | |||
T24135 |
HEC72702
HEC-72702,HEC 72702 |
||
HEC72702 is a novel Hepatitis B virus capsid inhibitor, based on clinical candidate GLS4. HEC72702 was found to display no induction of the CYP1A2, CYP3A4, or CYP2B6 enzyme at the high concentration of 10 μM. | |||
T26756 |
BCM-599
BCM 599 |
||
BCM-599 is a HBV capsid assembly inhibitor. BCM-599 showed IC50 of 0.88 μM and CC50 of 144 μM in HepG2.2.15 cells. | |||
TP1739 |
HEX3
|
||
HEX3 is a truncated form of the adenoviral hexon, which serves as the primary capsid protein for adenovirions. It consists of three identical polypeptide chains. | |||
T13284 |
Vapendavir diphosphate
BTA798 diphosphate |
Others | Others |
Vapendavir diphosphate is a potent enteroviral capsid binder (CB) and has a potent antiviral activity for enterovirus 71 (EV71) replication (EC50: 0.5-1.4 μM in different EV71 strains). | |||
T13284L |
Vapendavir
BTA798 |
Others | Others |
Vapendavir is a potent enteroviral capsid binder. Vapendavir has an effective antiviral activity for enterovirus 71 replication (EC50: 0.5-1.4 μM in different EV71 strains). | |||
T27030 |
CK176
HIV-1 inhibitor-34,HIV-1 inhibitor 34,CK 176,CK-176,HIV-1 inhibitor34 |
||
CK176 is a capsid targeted inhibitor of HIV-1 replication. CK176 shows an 11-fold improvement over I-XW-053 in blocking HIV-1 replication in primary human peripheral blood mononuclear cells (PBMCs). | |||
T78300 |
Anivovetmab
KIND-030 |
||
Anivovetmab (KIND-030)为针对细小病毒主要衣壳蛋白的IgG2型单克隆抗体,潜在应用于研究犬细小病毒感染。 | |||
T61462 |
EV-A71-IN-1
|
||
EV-A71-IN-1 is a potent inhibitor of the human enterovirus A71 (EV-A71) capsid protein, with an EC50 of 0.27 μM against EV-A71. Acting as a capsid binder, EV-A71-IN-1 disrupts the crucial interaction between the viral VP1 protein and the host receptor hSCARB2. It displays broad-spectrum antiviral activity against various human enteroviruses, while being non-toxic to human cells (CC50 > 56.2 μM) [1]. | |||
T62505 | SHR5133 | ||
SHR5133 是一种高效的、口服具有活力的 HBV 衣壳组装调节剂,能够减少 HBV DNA (EC50: 26.6 nM)。 | |||
T63687 |
HIV-1 inhibitor-18
|
||
HIV-1 inhibitor-18 是 HIV-1 衣壳的有效抑制剂,能够作用于 HIV-1 NL4-3 病毒株 (EC50: 5.14 μM),并表现出一定的细胞毒性 (MT-4CC50>9.51)。 | |||
T61558 |
HBV-IN-21
|
||
HBV-IN-21 (Compound II-8b) is a potent inhibitor of HBV DNA replication, exhibiting an IC50 of 2.2 μM. It demonstrates a favorable binding affinity (K D = 60.0 μM) for the HBV 4 capsid protein, thereby enabling effective interaction [1]. | |||
T73492 |
AB-836
|
||
AB-836 是一种口服活性HBV 衣壳抑制剂。AB-836 通过与HBV 核心蛋白相互作用抑制病毒复制。 | |||
T74211 | HIV-1 inhibitor-12 | ||
HIV-1inhibitor-12 是有效的 HIV-1抑制剂。HIV-1inhibitor-12 抑制 HIV-1衣壳蛋白聚合,IC50为 9 nM。 | |||
T78756 | Yhhu6669 | HBV | Microbiology/Virology |
Yhhu6669为抗HBV药物,能够抑制HBVDNA。该化合物通过诱导无DNA衣壳的形成,从而抑制HBV复制,且能有效降低AAV/HBV感染小鼠中的HBVDNA及HBcAg水平,展现出优良的药代动力学特性。 | |||
T69925 |
NVR3-778 hydrate
|
||
NVR 3-778 is the first capsid assembly modulator (CAM) that has demonstrated antiviral activity in hepatitis B virus (HBV)-infected patients. NVR 3-778 inhibited the generation of infectious HBV DNA-containing virus particles with a mean antiviral 50% effective concentration (EC50) of 0.40 µM in HepG2.2.15 cells. The antiviral profile of NVR 3-778 indicates pan-genotypic antiviral activity and a lack of cross-resistance with nucleos(t)ide inhibitors of HBV replication. | |||
T62466 |
HBV-IN-17
|
||
HBV-IN-17 (compound 8) 是一种有效的 HBV 衣壳组装调节剂 (EC50: 511 nM)。 | |||
T9769 |
Bersacapavir(JNJ-56136379)
|
||
Bersacapavir 是一种新型体外乙肝病毒衣壳组装调节剂,具有双重作用模式。 | |||
T38374 |
2-hydroxy Myristic Acid
|
||
2-hydroxy Myristic acid is a hydroxy fatty acid that has been found in bovine, human, and horse milk, cow and buffalo cheeses, sea bass filet, seal oil, human vernix caseosa, and wool wax. It inhibits cleavage between the enterovirus capsid proteins VP4 and VP2, a process required for enterovirus infectivity, as well as Junin and Tacaribe viral replication (IC50s = 20.1 and 14.2 μM, respectively). 2-hydroxy Myristic acid was previously characterized as a weak inhibitor of peptide myristoylation ... | |||
T64131 | HIV-1 inhibitor-17 | ||
HIV-1 inhibitor-18 是一种 HIV-1 衣壳的有效抑制剂,能够作用于 HIV-1 NL4-3 病毒株 (EC50: 2.57 μM)。HIV-1 inhibitor-18 表现出一定的细胞毒性,其 MT-4CC50 值大于8.55。 | |||
T73500 | AB-506 | ||
AB-506 是一种具有口服活性的,靶向病毒核心蛋白 HBV 复制的抑制剂。AB-506 可以与 HBV 核心蛋白结合,加速衣壳组装并抑制 HBV pgRNA 包壳。AB-506 可用于慢性乙型肝炎 (CHB)研究。 | |||
T76578 |
H-Gly-Pro-Gly-NH2
|
||
H-Gly-Pro-Gly-NH2 是一种抑制 HIV-1复制的三肽。H-Gly-Pro-Gly-NH2 抑制 HIV-1IIIB 和 HIV-2ROD 的活性,EC50值分别为 35 µM 和 30 µM。H-Gly-Pro-Gly-NH2 通过干扰衣壳形成来抑制 HIV-1的体外复制。H-Gly-Pro-Gly-NH2 具有抗病毒活性,可用于病毒研究。 | |||
T62170 |
H1PVAT
|
||
H1PVAT 是一种强效的、选择性的脊髓灰质炎病毒 (PV) 血清型 PV-1,PV-2,PV-3 抑制剂,对病毒的早期复制具有抑制作用。H1PVAT 能够直接作用于病毒衣壳,保护 PV 免受热灭活。 | |||
T80375 |
Human α-defensin 5
|
Parasite | Microbiology/Virology |
Human α-defensin 5 是抗病毒肽,能够阻断多种无包膜病毒感染,如AdV、HPV以及多瘤病毒(IC50: HPV16为0.6-1.25 μM)。它通过与病毒衣壳结合来阻止病毒从内体逃逸,并能增强HIV与细胞表面的结合作用。此外,Human α-defensin 5 还具备对抗寄生虫的活性。 | |||
T83704 |
A20FMDV2 TFA
|
||
A20FMDV2是一种由口蹄疫病毒(FMDV)血清型O的VP1衣壳蛋白上的α-螺旋RGD细胞相互作用域组成的肽,能够结合到αVβ6整合素上。该化合物在表达人αVβ6的H357舌鳞状细胞癌细胞中抑制αVβ6整合素依赖的细胞粘附(IC50 = 1.2 µM)。与111indium-DTPA耦合时,A20FMDV2(20 MBq)可结合于在乳腺癌小鼠异种移植模型中内源性表达的αVβ6整合素,用于放射成像分析。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3345 |
Hederasaponin B
常春藤皂苷B,Eleutheroside M,刺五加叶中,Hederacoside B |
Others; Virus Protease | Microbiology/Virology; Others |
Hederasaponin B (Hederacoside B) 是从Hedera helix 中分离的,有广谱抗病毒活性。 | |||
T5782 |
Bevirimat
YK FH312,MPC-4326,PA-457,贝韦立马 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Bevirimat (PA-457) 是一种 HIV-1 成熟抑制剂,可在病毒体成熟过程中阻断 Gag 衣壳 (CA) 前体 CA-SPI 裂解为成熟的 CA 蛋白。 |