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Cat. No. | Product Name | Target | Signaling Pathways |
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T16279 |
Nebicapone
BIA 3-202 |
Others | Others |
Nebicapone is a reversible catechol-O-methyltransferase (COMT) inhibitor and is mainly metabolized by glucuronidation. Nebicapone is mainly peripherally acting inhibitor that decreases the biotransformation of L-DOPA to 3-O-methyl-DOPA by inhibition of CO | |||
T35431 |
(±)-Clopidogrel (hydrochloride)
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Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM). Clopidogrel inhibits ADP-induced platelet aggregation ex vivo and functions as a prodrug whereupon biotransformation to its active metabolite via CYP2C19 in the liver enables its anti-aggregating activity. Marketed under the name Plavix , clopidogrel in combination with aspirin has been shown to be beneficial in the prevention of vascu... | |||
T76114 |
Diaphorase
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Diaphorase 能从厌氧污泥生物中获得。Diaphorase 通过脱硝作用,催化六氢-1,3,5-三硝基-1,3,5-三嗪 (RDX) 的生物转化。 | |||
T36112 |
Clopidogrel Carboxylic Acid (hydrochloride)
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Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM). Clopidogrel inhibits ADP-induced platelet aggregation ex vivo and functions as a prodrug whereupon biotransformation to its active thiol metabolite via CYP2C19 in the liver enables its anti-aggregating activity. An estimated 15% of administered clopidogrel is metabolized by CYP2C19 to the thiol metabolite. Clopidogrel carboxylic acid i... | |||
T83786 |
8-Chloroadenosine-5'-triphosphate sodium
8-chloro ATP |
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8-Chloroadenosine-5’-triphosphate(8-chloro ATP)是抗癌剂8-chloro cAMP的活性代谢物,也是核苷酸腺苷5’-三磷酸(ATP)的衍生物。它通过8-chloro cAMP、8-chloroadenosine以及一磷酸和二磷酸中间体形成。应用8-chloro cAMP或8-chloroadenosine后,8-chloro ATP可累积长达12小时,与细胞生长抑制、内源性ATP水平下降以及患者源多发性骨髓瘤细胞中RNA合成减少(但DNA合成不受影响)相关。在1.5至8 mM浓度范围内,它抑制topoisomerase II-α依赖的超螺旋pUC19 DNA放松,同时在1 mM时减少了K562人髓性白血病细胞中topoisomerase II-α催化的ATP水解50%。 | |||
T13421 |
(-)-Cevimeline hydrochloride hemihydrate
(-)-SNI-2011,(-)-AF102B hydrochloride hemihydrate |
ALK | Angiogenesis; Tyrosine Kinase/Adaptors |
(-)-Cevimeline hydrochloride hemihydrate ((-)-SNI-2011) 是一种新型mAChR 激动剂,是一种治疗干燥综合征口干症的候选治疗药物。 | |||
T35635 |
rac-trans-4-hydroxy Glyburide
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rac-trans-4-hydroxy Glyburide is an active metabolite of the SUR1/Kir6.2 sulfonylurea inhibitor glyburide .1,2It is formed from glyburide by the cytochrome P450 (CYP) isoforms CYP2C8 and CYP2C9.1rac-trans-4-hydroxy Glyburide inhibits glyburide binding to rat brain synaptosomes at the high and low affinity sites of SUR1/Kir6.2 with IC50values of 0.95 and 100 nM, respectively.2 1.Zharikova, O.L., Fokina, V.M., Nanovskaya, T.N., et al.Identification of the major human hepatic and placental enzymes ... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T41044 |
Naringinase
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Glucosidase | Metabolism |
Naringinase 是一种在自然界中广泛存在的水解酶复合物,具有 α-L-鼠李糖苷酶和 β-D-葡萄糖苷酶的活性,主要用于糖苷的水解。 | |||
Fr13756 |
Isonicotinic acid
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Endogenous Metabolite; Drug Metabolite | Metabolism |
Isonicotinic acid 是 Isoniazid 的代谢产物。Isoniazid 通过肼解转化为 Isonicotinic acid。 Isoniazid 向 Isonicotinic acid 的生物转化可以通过细胞色素 P450 酶催化。 | |||
T3881 |
Vaccarin
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Integrin; Akt; PERK; AMPK | Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
Vaccarin 是从王不留行中提取的一种黄酮糖苷,可显著促进伤口愈合以及伤口部位的内皮和成纤维细胞增殖。它通过激活 AMPK 信号通路改善胰岛素抵抗和脂肪变性。 | |||
T6S1559 |
Aurantio-obtusin
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Others | Others |
Aurantio-obtusin 是从决明子中分离出的蒽醌类化合物,具有抗炎、抗凝血、抗氧化、抗高血压的活性。它能抑制 IgE 介导的肥大细胞和过敏模型中的过敏反应,具有研究过敏相关疾病的潜力。在大鼠中,它通过内皮细胞 PI3K/AKT/ eNOS 依赖信号通路放松全身动脉,是潜在的新型血管扩张剂。 | |||
T83584 |
(±)-Lavandulol
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(±)-Lavandulol为一不对称的单萜醇,能由米根霉(Rhizopus oryzae)真菌转化为其对应氧化代谢产物。 | |||
T83241 |
7-Hydroxy-TSU-68
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7-Hydroxy-TSU-68为TSU-68的衍生物,该化合物为TSU-68在人类肝微粒体内经生物转化途径形成的代谢产物,其含量标识了TSU-68自身诱导的羟基化程度。 | |||
T83320 |
4'-Demethylpodophyllotoxone
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4'-Demethylpodophyllotoxone为链格孢(Alternaria alternata)S-f6的生物转化中间产物,经4-(2,3,5,6-tetramethylpyrazine-1) (4-TMP)修饰后形成的新化合物,可有效抑制人胃癌细胞系(BGC-823)的生长。 |