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Search Results for " antibody-drug conjugate "

263

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T18479	NH-bis(C1-Boc) 亚氨基二乙酸二异丁酯	Others	Others
	Boc-NH-C6-Br 是一种不可切割的接头，用于抗体-药物偶联物。
T21408	DM1-SMe DM1-SSMe	Microtubule Associated	Cytoskeletal Signaling
	DM1-SMe (DM1-SSMe) 是美登木素微管的有效抑制剂。 DM1-SMe 的效力是母体药物美登素的 3 至 10 倍，在一组人类肿瘤细胞系中，DM1-SMe 的 IC50 为 0.003 至 0.01 nM。
T14061	EMCS 6-Maleimidohexanoic acid N-hydroxysuccinimide ester	Others	Others
	EMCS (6-Maleimidohexanoic acid N-hydroxysuccinimide ester) 是一种异双官能团交联剂，是一种制备半抗原结合物和酶免疫偶联物的化合物，是抗体药物偶联物中一种有效的保护基团。
T4289	Mc-Val-Ala-PAB Mc-Val-Ala-PAB	Others; AChR	Neuroscience; Others
	Mc-Val-Ala-PAB 是一种可降解的 ADC 接头，用于抗体-药物偶联物。
T76769	Indusatumab	Guanylate cyclase	GPCR/G Protein
	Indusatumab (5F9 Monoclonal antibody) 是一种 anti-human GUCY2C (Guanylate cyclase 2C) 单克隆抗体，可用于合成抗体-药物偶联物。
T1910	Ansamitocin P 3' Maytansinol butyrate,Ansamitocin P-3,安丝菌素P-3,Antibiotic C 15003P3'	Microtubule Associated	Cytoskeletal Signaling
	Ansamitocin P 3' (Maytansinol butyrate) 是一种具有抗肿瘤活性的抗体-药物偶联细胞毒素。
T16899	SMCC-DM1 DM1-SMCC	Others	Others
	SMCC-DM1 (DM1-SMCC) 是一种药物-接头偶联物，由有效的微管破坏剂 DM1 和接头 SMCC 组成，用于制备抗体药物偶联物。
T77406	lorvotuzumab	Others	Others
	Lorvotuzumab (Anti-NCAM1/CD56 Reference Antibody (lorvotuzumab)) 是一种人源化结合 CD56 (NCAM1) 的单克隆抗体。Lorvotuzumab 可用于合成抗体-药物偶联物（ Lorvotuzumab mertansine）。
T16031	McMMAF Maleimidocaproyl monomethylauristatin F	Microtubule Associated	Cytoskeletal Signaling
	McMMAF 是一种保护基团共轭的 MMAF。它是一种具有马来酰亚胺基己酰基接头（MC 接头）的 MMAF 衍生物， MMAF 是一种有效的微管蛋白聚合抑制剂。它可与抗体或其他蛋白质或生物聚合物结合。
T15141	DM4 Ravtansine,美登素 DM4	Others; Microtubule Associated	Cytoskeletal Signaling; Others
	DM4 (Ravtansine)可用于制备抗体药物偶联物，是抗微管蛋白剂。它抑制细胞分裂。
T5149	MC-Val-Cit-PAB N-[6-(2,5-二氢-2,5-二氧代-1H-吡咯-1-基)-1-氧代己基]-L-缬氨酰-N5-(氨基甲酰基)-N-[4-(羟甲基)苯基]-L-鸟氨酰胺	Others; AChR	Neuroscience; Others
	MC-Val-Cit-PAB 是一种组织蛋白酶可裂解的 ADC 接头，用于制备抗体-药物偶联物。
T18529	PDEC-NB 4-Nitrophenyl 2-(Pyridin-2-Yldisulfanyl)Ethyl Carbonate	Others	Others
	PDEC-NB (4-Nitrophenyl 2-(Pyridin-2-Yldisulfanyl)Ethyl Carbonate) 是用于抗体-药物偶联物的二硫键可切割接头。
T18870	Vc-MMAD	Others	Others
	Vc-MMAD 由 linker (Val-Cit) 和微管抑制剂 MMAD 组成。Vc-MMAD 可用于偶联抗体。
T17731L	CL2A-SN-38 DCA 1279680-68-0(free base)	Others	Others
	CL2A-SN-38 DCA 1279680-68-0(free base) 是一种药物-接头偶联物，由有效的 DNA 拓扑异构酶 I 抑制剂 SN-38 和接头 CL2A 组成，用于制造抗体药物偶联物 (ADC)。CL2A-SN-38 由有效的 DNA 拓扑异构酶组成I 抑制剂 SN-38 和接头 CL2A 以制造抗体药物偶联物 (ADC)。 CL2A-SN-38 对一系列人类实体瘤类型提供显着和特异性的抗肿瘤作用。 CL2A 是一种不可切割的复杂 PEG8 和含有三唑的 PABC-肽-mc 接头。 CL2A 可通过 pH 敏感性裂解，产生旁观者效应，并通过二硫键在半胱氨酸残基处结合抗体。
T4286	Fmoc-Val-Ala-PAB-OH Fmoc-Val-Ala-PAB	Others; AChR	Neuroscience; Others
	Fmoc-Val-Ala-PAB-OH (Fmoc-Val-Ala-PAB) 是一种有用的接头，可用于制备用于靶向药物递送的抗体-药物偶联物。它还用于合成带有溶酶体可切割接头的 RGD 拟肽-紫杉醇缀合物。
T77909	Mirzotamab
	Mirzotamab clezutoclax（ABBV-155）是一种IgG1κ型靶向CD276/B7-H3的抗体偶联物（ADC），通过与BCL抑制剂Clezutoclax结合而构成。该化合物用于参与针对复发/难治性实体瘤的紫杉烷相关研究。
T15176	DSS Crosslinker	Others	Others
	DSS Crosslinker 是一种不可切割的 ADC 连接剂，用于合成抗体-药物偶联物。
T9227	Val-Ala-PAB	Others	Others
	Val-Ala-PAB 是 Tesirine (a.k.a. SG3249) 合成的基石，Tesirine 是一种临床抗体-药物偶联物吡咯并苯二氮卓二聚体有效载荷。制备吡咯并苯二氮卓二聚体及其抗体缀合物的试剂，该试剂含有可用于治疗包括癌症在内的增殖性疾病的肽接头。
FL0195	N-Boc-4-hydroxy-L-proline methyl ester
	N-Boc-cis-4-hydroxy-L-proline methyl ester为不可降解(non-cleavable)的ADC linker，用于抗体药物偶联体(ADCs)合成。该化合物同时作为基于烷基链(alkyl chain)的PROTAC linker，适用于PROTAC合成。
T1992	Mertansine DM1,Maytansinoid DM1	Microtubule Associated	Cytoskeletal Signaling
	Mertansine (DM1) 是一种微管蛋白抑制剂，也是一种抗体可缀合的美登木素生物碱。它通过连接体连接到单克隆抗体上，形成抗体偶联药物。
T18702	DBA-DM4	Others	Others
	DBA-DM4 is a drug-linker conjugate for antibody-drug conjugate (ADC) synthesis, combining the tubulin inhibitor DM1 with the SPDP linker[1].
T10832	CL2-SN-38	Others	Others
	CL2-SN-38, a part of the antibody-drug conjugate (ADC), can conjugate with the anti-Trop-2-humanized antibody hRS7. SN-38 is an inhibitor of DNA topoisomerase I.
T39238	DBM-MMAF
	DBM-MMAF is a drug-linker conjugate composed of a potent antitubulin agent MMAF and a linker DBM to make antibody drug conjugate (ADC).
T18504	Nitro-PDS-Tubulysin M	Others	Others
	Nitro-PDS-Tubulysin M, an ADC (Antibody-Drug Conjugate) drug-linker conjugate, exhibits potent antitumor activity. It employs Tubulysin M, a tubulin polymerization inhibitor, connected through the Nitro-PDS ADC linker.
T18317	MCC-Modified Daunorubicinol	Others	Others
	Daunorubicinol, a potent antitumor drug-linker conjugate for antibody-drug conjugate (ADC) applications, utilizes Aur0101 (DNA Topoisomerase II inhibitor) connected through the ADC linker[1].
T38788	MC-DM1 MC-DM1
	MC-DM1 is a drug-linker conjugate composed of a potent microtubule-disrupting agent DM1 and a linker MC to make antibody drug conjugate (ADC).
T38682	Lys-Nε-SPDB-DM4 Lys-Nε-SPDB-DM4
	Lys-Nε-SPDB-DM4 is a drug-linker conjugate composed of a potent a tubulin inhibitor DM4 and a linker Lys-Nε-SPDB to make antibody drug conjugate (ADC).
T18304	Mal-VC-PAB-ABAEP-Azonafide	Others	Others
	Mal-VC-PAB-ABAEP-Azonafide, an ADC (antibody-drug conjugate) linker-drug conjugate, demonstrates potent antitumor activity. It incorporates Azonafide, a cytotoxin, connected through the ADC linker Mal-VC-PAB[1].
T18699	SNPB	Others	Others
	SNPB is a cleavable linker that is used for making antibody-drug conjugate (ADC).
T39941	MP-PEG4-Val-Lys-Gly-7-MAD-MDCPT MP-PEG4-Val-Lys-Gly-7-MAD-MDCPT
	MP-PEG4-Val-Lys-Gly-7-MAD-MDCPT is a Camptothecin-linker. MP-PEG4-Val-Lys-Gly-7-MAD-MDCPT is a drug-linker conjugate for antibody-drug conjugate (ADC).
T17816	DBCO-Val-Cit-PABC-PNP	Others	Others
	DBCO-Val-Cit-PABC-PNP is a cleavable linker for antibody-drug conjugate (ADC) synthesis[1].
T18700	SPB	Others	Others
	SPB is a potent anti-inflammatory drug-linker conjugate for Antibody-Drug Conjugates (ADC), utilizing Xanthotoxol connected through the ADC linker.
T18701	SPDB-DM4	Others	Others
	SPDB-DM4 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications, employing the maytansine-based payload DM4 (a tubulin inhibitor) connected through a SPDB linker. This compound demonstrates significant anti-tumor efficacy.
T18310	AZ1508 MC-Lys-MMETA	Others	Others
	AZ1508, a tubulin inhibitor[1], serves as a drug-linker conjugate for antibody-drug conjugates (ADC) targeting breast and stomach cancer treatment.
T39316	DGN549-L DGN549-L
	DGN549-L is a DNA alkylator that facilitates antibody conjugation at lysine residues, making it suitable for antibody-drug conjugate (ADC) synthesis.
T12149	N-Me-L-Ala-maytansinol	Others	Others
	N-Me-L-Ala-maytansinol used for making antibody-drug conjugate (ADC),is a hydrophobic, cell permeable payload.
T39257	Ugodotin
	Ugodotin is an antibody-drug conjugate. Ugodotin can binds IGF-1R with antitumor activity.
T18463	NHS-C4-MTS N-Succinimidyloxycarbonylpropyl methanethiosulfonate	Others	Others
	N-Succinimidyloxycarbonylpropyl methanethiosulfonate (SMPM) is a non-cleavable antibody-drug conjugate (ADC) linker employed for ADC synthesis[1].
T18465	N3-C2-NHS ester	Others	Others
	N3-C2-NHS ester is a noncleavable antibody-drug conjugate (ADC) linker employed for the synthesis of ADCs.
T18731	Sulfo-PDBA-DM4	Others	Others
	Sulfo-PDBA-DM4 is a drug-linker conjugate for antibody-drug conjugate (ADC) applications, combining the potent tubulin inhibitor DM4 with the gluthatione-cleavable linker Sulfo-PDBA. This configuration harnesses DM4's cytotoxic potential through Sulfo-PDBA's targeted delivery mechanism.
T18802	Tetrazine-SS-Biotin	Others	Others
	Tetrazine-SS-Biotin, a cleavable ADC linker, finds utility in ADC (antibody-drug conjugate) synthesis [1].
T17385	Ald-Ph-amido-PEG3-C2-Pfp ester	Others	Others
	Ald-Ph-amido-PEG3-C2-Pfp ester is a noncleavable antibody-drug conjugate (ADC) linker that falls under the category of polyethylene glycol (PEG) linkers.
T17447	Aminoxyacetamide-PEG3-azide	Others	Others
	Aminoxyacetamide-PEG3-azide is a non-cleavable 3-unit polyethylene glycol linker employed for antibody-drug conjugate (ADC) synthesis[1].
T18330	MC-Val-Cit-PAB-vinblastine	Others	Others
	MC-Val-Cit-PAB-vinblastine is a potent antitumor drug-linker conjugate for Antibody-Drug Conjugates (ADC), featuring vinblastine (a microtubule protein inhibitor) connected through the MC-Val-Cit-PAB ADC linker.
T17833	DM4-SMCC	Others	Others
	DM4-SMCC, a non-cleavable drug-linker conjugate for antibody-drug conjugates (ADC), leverages the antitumor efficacy of DM4 (an antitubulin agent) through attachment with the SMCC linker, exhibiting antitumor activity[1].
T17981	Fmoc-Phe-Lys(Boc)-PAB-PNP	Others	Others
	Fmoc-Phe-Lys(Boc)-PAB-PNP is a cleavable antibody-drug conjugate (ADC) linker employed in the synthesis of ADCs.
T18644	PTAD-PEG4-N3	Others	Others
	PTAD-PEG4-N3 is a cleavable four-unit polyethylene glycol (PEG) antibody-drug conjugate (ADC) linker, utilized in ADC synthesis[1].
T39164	MC-betaglucuronide-MMAE-1
	MC-betaglucuronide-MMAE-1 is a potent antitumor drug-linker conjugate for antibody-drug conjugates (ADCs), employing MMAE (a tubulin polymerization inhibitor) connected through the cleavable ADC linker MC-betaglucuronide.
T18311	Mc-MMAD	Others	Others
	Mc-MMAD, a drug-linker conjugate for antibody-drug conjugates (ADCs), incorporates the protective group maleimidocaproyl (Mc) conjugated to monomethyl auristatin D (MMAD), a potent inhibitor of tubulin.
T18717	SPDV	Others	Others
	SPDV is a cleavable antibody-drug conjugate (ADC) linker utilized in the diagnostic and therapeutic management of cancer and B cell proliferative diseases.

化合物

Cat.No: T18479

Synonym: 亚氨基二乙酸二异丁酯

Target: Others

Cat.No: T21408

Synonym: DM1-SSMe

Target: Microtubule Associated

Cat.No: T14061

Synonym: 6-Maleimidohexanoic acid N-hydroxysuccinimide ester

Target: Others

Cat.No: T4289

Synonym: Mc-Val-Ala-PAB

Target: Others, AChR

Cat.No: T76769

Target: Guanylate cyclase

Ansamitocin P 3'

Cat.No: T1910

Synonym: Maytansinol butyrate,Ansamitocin P-3,安丝菌素P-3,Antibiotic C 15003P3'

Target: Microtubule Associated

Cat.No: T16899

Synonym: DM1-SMCC

Target: Others

Cat.No: T77406

Target: Others

Cat.No: T16031

Synonym: Maleimidocaproyl monomethylauristatin F

Target: Microtubule Associated

Cat.No: T15141

Synonym: Ravtansine,美登素 DM4

Target: Others, Microtubule Associated

Cat.No: T5149

Synonym: N-[6-(2,5-二氢-2,5-二氧代-1H-吡咯-1-基)-1-氧代己基]-L-缬氨酰-N5-(氨基甲酰基)-N-[4-(羟甲基)苯基]-L-鸟氨酰胺

Target: Others, AChR

Cat.No: T18529

Synonym: 4-Nitrophenyl 2-(Pyridin-2-Yldisulfanyl)Ethyl Carbonate

Target: Others

Cat.No: T18870

Target: Others

CL2A-SN-38 DCA 1279680-68-0(free base)

Cat.No: T17731L

Target: Others

Fmoc-Val-Ala-PAB-OH

Cat.No: T4286

Synonym: Fmoc-Val-Ala-PAB

Target: Others, AChR

Cat.No: T77909

DSS Crosslinker

Cat.No: T15176

Target: Others

Cat.No: T9227

Target: Others

N-Boc-4-hydroxy-L-proline methyl ester

Cat.No: FL0195

Cat.No: T1992

Synonym: DM1,Maytansinoid DM1

Target: Microtubule Associated

Cat.No: T18702

Target: Others

Cat.No: T10832

Target: Others

Cat.No: T39238

Nitro-PDS-Tubulysin M

Cat.No: T18504

Target: Others

MCC-Modified Daunorubicinol

Cat.No: T18317

Target: Others

Cat.No: T38788

Synonym: MC-DM1

Lys-Nε-SPDB-DM4

Cat.No: T38682

Synonym: Lys-Nε-SPDB-DM4

Mal-VC-PAB-ABAEP-Azonafide

Cat.No: T18304

Target: Others

Cat.No: T18699

Target: Others

MP-PEG4-Val-Lys-Gly-7-MAD-MDCPT

Cat.No: T39941

Synonym: MP-PEG4-Val-Lys-Gly-7-MAD-MDCPT

DBCO-Val-Cit-PABC-PNP

Cat.No: T17816

Target: Others

Cat.No: T18700

Target: Others

Cat.No: T18701

Target: Others

Cat.No: T18310

Synonym: MC-Lys-MMETA

Target: Others

Cat.No: T39316

Synonym: DGN549-L

N-Me-L-Ala-maytansinol

Cat.No: T12149

Target: Others

Cat.No: T39257

Cat.No: T18463

Synonym: N-Succinimidyloxycarbonylpropyl methanethiosulfonate

Target: Others

N3-C2-NHS ester

Cat.No: T18465

Target: Others

Cat.No: T18731

Target: Others

Tetrazine-SS-Biotin

Cat.No: T18802

Target: Others

Ald-Ph-amido-PEG3-C2-Pfp ester

Cat.No: T17385

Target: Others

Aminoxyacetamide-PEG3-azide

Cat.No: T17447

Target: Others

MC-Val-Cit-PAB-vinblastine

Cat.No: T18330

Target: Others

Cat.No: T17833

Target: Others

Fmoc-Phe-Lys(Boc)-PAB-PNP

Cat.No: T17981

Target: Others

Cat.No: T18644

Target: Others

MC-betaglucuronide-MMAE-1

Cat.No: T39164

Cat.No: T18311

Target: Others

Cat.No: T18717

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T4820	Maleimide 马来酰亚胺,2,5-Pyrroledione	Others	Others
	Maleimide (2,5-Pyrroledione) 可用于制备荧光探针，主要用于硫醇分析物的特异性检测。它也可用于制备用于癌症研究的抗体-药物偶联物 (ADC)。
T39562	γ-Amanitin
	γ-Amanitin an ADC cytotoxin and isolated from the mushroom. γ-Amanitin inhibits RNA polymerase II and disrupts synthesis of mRNA. γ-Amanitin shows similar effects to α-Amanitin and β-Amanitin.
T73915	Luisol A
	Luisol A 是一种芳香族四醇，是链霉菌属的河口海洋放线菌的主要代谢产物。Luisol A 是一种蒽醌抗生素类似物，是 ADC 细胞毒素 (ADC Cytotoxin)。

天然产物

Cat.No: T4820

Synonym: 马来酰亚胺,2,5-Pyrroledione

Target: Others

Cat.No: T39562

Cat.No: T73915

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