Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2316 |
Omarigliptin
MK-3102,奥格列汀 |
Proteasome; DPP-4 | Proteases/Proteasome; Ubiquitination |
Omarigliptin (MK-3102) 是高效选择性 DPP4抑制剂,IC50=为1.6nM。 | |||
T6766 |
Atipamezole
Antisedan,阿替美唑,MPV 1248 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Atipamezole (Antisedan) 是 α2-肾上腺素受体拮抗剂,Ki=1.6 nM。 | |||
T6765 |
Atipamezole hydrochloride
阿替美唑盐酸盐,MPV-1248 hydrochloride,Antisedan |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Atipamezole hydrochloride (MPV-1248 hydrochloride) 是一种 α2-肾上腺素受体拮抗剂,Ki=1.6 nM。 | |||
T21446 |
Rotigotine Hydrochloride
Rotigotine (Hydrochloride),N 0923,N-0924,Rotigotine HCl,盐酸罗替戈汀,N-0923,罗替戈汀盐酸盐 |
Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Rotigotine Hydrochloride (N-0924) 是多巴胺受体激动剂,是5-HT1A 受体的部分激动剂,以及α2B-肾上腺素受体的拮抗剂,具有抗帕金森病活性。 | |||
T1406L |
Amantadine sulfate
1-Adamantanamine Sulfate |
||
Amantadine is used both as an antiviral and an anti-parkinsonian drug. Amantadine is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release, and blocks dopamine reuptake. The drug has many effects in the brain, including the rel | |||
T74770 | D-685 | ||
D-685作为D-520的前体药物,在帕金森病(PD)血脂化动物模型中展示了优于D-520的体内抗PD功效。此外,D-685能降低人类α-突触核蛋白(α-syn)的累积,且具有更高的大脑透过性。 |