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23

抑制剂 & 化合物

12

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T60020	5'-Fluoro-5'-deoxyadenosine 5'-Fluoro-5'-deoxy-adenosine	Others	Others
	5'-Fluoro-5'-deoxyadenosine (5'-Fluoro-5'-deoxy-adenosine) 常用作研究放线菌卡特链霉菌的工具。
T34643	Simaomicin alpha L D42067alpha,LL D42067alpha,LL-D42067alpha
	Simaomicin alpha is an actinomycete metabolite isolated from an actinomycete strain.
T33705	N-Methylstreptothricin F A37812,A 37812,A-37812
	N-Methylstreptothricin F is a streptothrycin isolated from actinomycete.
T25732	Lincomycin-B U21699,U-21699,U 21699,Antibiotic U 21699
	Lincomycin-B is a lincosamide antibiotic isolated from the actinomycete Streptomyces lincolnensis.
T25994	Propioxatin B
	Propioxatin B is an enkephalinase B inhibitor isolated from actinomycete.
T25993	Propioxatin A
	Propioxatin A is an enkephalinase B inhibitor isolated from actinomycete.
T34493	Salinosporamide B
	Salinosporamide B is a deschloro analog isolated from the marine Actinomycete Salinispora tropica.
T26455	A 83016F A-83016F,A83016F
	A 83016F, an antibiotic from an actinomycete designated A83016, exhibits weak antimicrobial activity.
T34494	Salinosporamide C
	Salinosporamide C is a decarboxylated pyrrole analogue isolated from the marine Actinomycete Salinispora tropica.
T32949	Luminamicin
	Luminamicin is active against anaerobic bacteria, especially Clostridium sp.; isolated from actinomycete strain OMR-59.
T35735	Drimentine A
	Drimentine A is a terpenylated diketopiperazine antibiotic originally isolated from Actinomycete bacteria. It is active against Gram-positive and Gram-negative bacteria, fungi, and yeast and has anthelmintic properties.
T38386	Drimentine C
	Drimentine C is a terpenylated diketopiperazine antibiotic originally isolated from Actinomycete bacteria. It inhibits proliferation of NS-1 murine β lymphocyte myeloma cells by 63 and 98% in vitro when used at concentrations of 12.5 and 100 μg/ml, respectively.
T37007	Resistoflavine
	Resistoflavine is a metabolite of the marine actinomycete S. chibaensis. It slows the growth of and is cytotoxic to HMO2 and HepG2 cells with mean lethal concentrations (LC50) of 0.013 and 0.016 μg/ml, respectively.
T37509	Saccharocarcin B
	Saccharocarcin B 是从放线菌 Saccharothrix aerocolongenes subsp.antibiotica SCC1886 的发酵液中分离出来的。
T76282	Friulimicin D
	Friulimicin D 是一种脂肽类抗生素，同 Friulimicin B 一样，都是从放线菌Actinoplanes friuliensis 中分离得到。
T76281	Friulimicin A
	Friulimicin A 是一种脂肽类抗生素，同 Friulimicin B 一样，都是从放线菌Actinoplanes friuliensis 中分离得到。
T37546	TPU-0037C
	TPU-0037C is a metabolite of the marine actinomycete S. platensis that is structurally similar to lydicamycin . It is active against Gram-positive bacteria (MICs = 0.39-3.13 μg/ml), including methicillin-resistant S. aureus strains (MIC = 3.13 μg/ml), but is ineffective against Gram-negative bacteria (MICs = >50 μg/ml).
T40676	Erythromycin A dihydrate
	Erythromycin dihyrate dihydrate is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin dihyrate acts by binding to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid.
T68207	Elsamitrucin
	Elsamitrucin is a heterocyclic antineoplastic antibiotic isolated from the bacterium Actinomycete strain J907-21. Elsamitrucin intercalates into DNA at guanine-cytosine (G-C)-rich sequences and inhibits topoisomerase I and II, resulting in single-strand breaks and inhibition of DNA replication. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
T35736	Drimentine B
	Drimentine B is a terpenylated diketopiperazine antibiotic originally isolated from Actinomycete bacteria. It is active against Gram-positive and Gram-negative bacteria, fungi, and yeast, and has anthelmintic properties. Drimentine B inhibits proliferation of NS-1 murine β lymphocyte myeloma cells by 41 and 59% in vitro when used at concentrations of 50 and 100 μg/ml, respectively.
T36402	Kibdelone C
	Kibdelone C is a member of a family of natural heterocyclic polyketides first isolated from a soil actinomycete, Kibdelosporangium. Kibdelones have been described as having potent and selective cytotoxicity against a panel of human tumor cell lines, and kibdelone C has low nanomolar effectiveness in these assays. Kibdelone C disrupts the actin cytoskeleton without directly binding actin or affecting its polymerization in vitro.
T78124	SF2312 ammonium	Antibiotic	Microbiology/Virology
	SF2312铵是SF2312的铵盐形式，后者为一种膦酸盐类抗生素兼烯醇酶抑制剂。该化合物可从放线菌小单孢菌分离而得，在缺氧环境中活性显著。SF2312对ENO1基因缺失的神经胶质瘤细胞显示出选择性毒杀作用。
T35742	IKD-8344
	IKD-8344 is a macrocyclic dilactone originally isolated from an actinomycete species and has diverse biological activities, including anticancer, antimicrobial, and anthelmintic properties.1,2,3 It is cytotoxic to L5178Y murine leukemia cells (IC50 = 0.54 ng/ml).1 IKD-8344 inhibits growth of the mycelial form of C. albicans (MIC = 6.25 μg/ml) and potentiates the activity of polymyxin B against the multidrug-resistant pathogenic bacterium B. cenocepacia.2,3 It is active against T. spiralis in vit...

化合物

5'-Fluoro-5'-deoxyadenosine

Cat.No: T60020

Synonym: 5'-Fluoro-5'-deoxy-adenosine

Target: Others

Simaomicin alpha

Cat.No: T34643

Synonym: L D42067alpha,LL D42067alpha,LL-D42067alpha

N-Methylstreptothricin F

Cat.No: T33705

Synonym: A37812,A 37812,A-37812

Cat.No: T25732

Synonym: U21699,U-21699,U 21699,Antibiotic U 21699

Cat.No: T25994

Cat.No: T25993

Salinosporamide B

Cat.No: T34493

Cat.No: T26455

Synonym: A-83016F,A83016F

Salinosporamide C

Cat.No: T34494

Cat.No: T32949

Cat.No: T35735

Cat.No: T38386

Cat.No: T37007

Saccharocarcin B

Cat.No: T37509

Cat.No: T76282

Cat.No: T76281

Cat.No: T37546

Erythromycin A dihydrate

Cat.No: T40676

Cat.No: T68207

Cat.No: T35736

Cat.No: T36402

SF2312 ammonium

Cat.No: T78124

Target: Antibiotic

Cat.No: T35742

Cat. No.	Product Name	Target	Signaling Pathways
T1032	Erythromycin 红霉素,E-Mycin	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Erythromycin (E-Mycin) 是由放线菌产生的大环内酯类抗生素。它结合细菌的 50S 核糖体亚基，通过阻断转肽和易位反应来抑制 RNA 依赖性蛋白的合成。
T15277	Fervenulin	Parasite	Microbiology/Virology
	Fervenulin 具有杀灭线虫活性，抑制线虫M. incognita 卵孵化和 J2 的校正死亡率，MIC 分别为 30 μg/mL 和 120 μg/mL。
T0895	Oxytetracycline 土霉素,Terramycin	ribosome; Endogenous Metabolite; Antibacterial; Antibiotic; HSV	Metabolism; Microbiology/Virology
	Oxytetracycline (Terramycin) 是一种四环素类抗生素。它强力抑制革兰氏阴性和革兰氏阳性细菌。它是一种蛋白质合成抑制剂，可阻止 aminoacil-tRNA 与复杂的核糖体 RNA 结合，具有抗 HSV-1的活性。
T17143	Toyocamycin 丰加霉素,Vengicide	Apoptosis; Others; IRE1; Antibiotic; Antifungal	Apoptosis; Cell Cycle/Checkpoint; Microbiology/Virology; Others
	Toyocamycin (Vengicide) 是放线菌类产生的腺苷类似物，为 X 盒结合蛋白 1 (XBP1) 抑制剂，抑制 IRE1α 诱导的 ATP 依赖性 XBP1 mRNA 的断裂，IC50值为 80 nM。它还诱导凋亡。
T28764	SF2312 SF-2312,SF 2312
	SF2312 is an enolase inhibitor produced by the actinomycete Micromonospora, which is active under anaerobic conditions.
T81660	Nocarimidazole A
	Nocarimidazole A，一种来源于海洋放线菌Nocardiopsis的白色无定形固体生物碱，具紫外线活性。
T1235L	Lincomycin U 10149,U10149,U-10149
	Lincomycin is a lincosamide antibiotic that comes from the actinomycete Streptomyces lincolnensis. Although similar in structure, antibacterial spectrum, and mechanism of action to macrolides, lincomycin is also effective against other organisms including
T15637	K-252b	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	K-252b is an indolocarbazole isolated from the actinomycete Nocardiopsis and is a PKC inhibitor. K-252b can be used to inhibit extracellular kinases of cells in culture because it can’t pass through the cell membrane freely.
T73915	Luisol A
	Luisol A 是一种芳香族四醇，是链霉菌属的河口海洋放线菌的主要代谢产物。Luisol A 是一种蒽醌抗生素类似物，是 ADC 细胞毒素 (ADC Cytotoxin)。
T11233	Erythromycin thiocyanate	Antibacterial	Microbiology/Virology
	Erythromycin thiocyanate acts by binding to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid .Erythromycin thiocyanate
T75522	Wychimicin C
	Wychimicin C为源自罕见放线菌Actinocrispum wychmicini菌株MI503-AF4的螺旋藻酸聚酮类化合物。此化合物展现出卓越的抗菌效果，尤其对耐甲氧西林的Staphylococcus. aureus（IC50=0.125-0.5 μg/mL）和Enterococcus. Faecalis/faecium（IC50=0.125-0.25 μg/mL）展现显著的抑制活性。
T75523	Wychimicin A
	Wychimicin A 是一种螺旋藻酸聚酮，可从罕见的放线菌 Actinocrispum wychmicini 菌株 MI503-AF4 中分离得到。Wychimicin A 具有强抗菌活性，显著抑制耐甲氧西林的金黄色葡萄球菌Staphylococcus. aureus(IC50=0.125-0.5 μg/mL) 和肠球菌Enterococcus. Faecalis/faecium(IC50=0.25 μg/mL)。

天然产物

Cat.No: T1032

Synonym: 红霉素,E-Mycin

Target: ribosome, Antibacterial, Antibiotic

Cat.No: T15277

Target: Parasite

Oxytetracycline

Cat.No: T0895

Synonym: 土霉素,Terramycin

Target: ribosome, Endogenous Metabolite, Antibacterial, Antibiotic, HSV

Cat.No: T17143

Synonym: 丰加霉素,Vengicide

Target: Apoptosis, Others, IRE1, Antibiotic, Antifungal

Cat.No: T28764

Synonym: SF-2312,SF 2312

Nocarimidazole A

Cat.No: T81660

Cat.No: T1235L

Synonym: U 10149,U10149,U-10149

Cat.No: T15637

Target: PKC

Cat.No: T73915

Erythromycin thiocyanate

Cat.No: T11233

Target: Antibacterial

Cat.No: T75522

Cat.No: T75523

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