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Cat. No. | Product Name | Target | Signaling Pathways |
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T1083L |
Theophylline monohydrate
Quibron,茶碱一水合物 |
HDAC; PDE; Adenosine Receptor | Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience |
Theophylline monohydrate (Quibron) 似乎抑制磷酸二酯酶和前列腺素的产生,调节钙通量和细胞内钙分布,并拮抗腺苷。茶碱是黄嘌呤的天然生物碱衍生物,从植物山茶花和小粒咖啡中分离出来。在生理上,该药剂可放松支气管平滑肌,产生血管舒张(脑血管除外),刺激中枢神经系统,刺激心肌,利尿,增加胃酸分泌;它还可以抑制炎症并改善横膈膜的收缩性。 | |||
T0829 |
Etofylline
7-(β-Hydroxyethyl)theophylline,乙羟茶碱,Aethophyllinum,可达岭,7-Theophyllineethanol,Oxyphylline,Cordalin |
Others | Others |
Etofylline (Oxyphylline) 是 Theophylline 的 N-7 取代衍生物。它是一种抗胆固醇药,可降低血液中的总胆固醇水平。它也是一种支气管扩张药,可用于研究哮喘。 | |||
T33062 | Lysine theophylline | ||
Lysine theophylline is a soluble theophylline. | |||
T71329 |
Theophylline-d6
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Theophylline-d6 is intended for use as an internal standard for the quantification of theophylline by GC- or LC-MS. Theophylline is an inhibitor of phosphodiesterase. It is also an adenosine A1 and A2 receptor antagonist. Theophylline induces relaxation of isolated cat bronchial smooth muscle segments precontracted with acetylcholine. It inhibits ovalbumin-induced increases in bronchoalveolar lavage fluid (BALF) eosinophil infiltration in an ovalbumin-sensitized mouse model of allergic asthma. F... | |||
T34839 | Theophylline, 7-ethyl-6-thio- | ||
Theophylline, 7-ethyl-6-thio- is a bioactive chemical. | |||
T34837 |
Theophylline, 7-(2-(diethylamino)ethyl)-6-thio-, methiodide
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Theophylline, 7-(2-(diethylamino)ethyl)-6-thio-, methiodide is a bioactive chemical. | |||
T34836 |
Theophylline, 7-(2-(diethylamino)ethyl)-6-thio-, hydrochloride
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Theophylline, 7-(2-(diethylamino)ethyl)-6-thio-, hydrochloride is a bioactive chemical. | |||
T60511 |
Theophylline sodium glycinate
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Theophylline (1,3-Dimethylxanthine) sodium glycinate 是一种有效的磷酸二酯酶 (PDE) 抑制剂,可抑制 PDE3 活性以松弛气道平滑肌。Theophylline sodium glycinate 可用于研究哮喘和慢性阻塞性肺疾病 (COPD) 。Theophylline sodium glycinate 也是一种腺苷受体拮抗剂和组蛋白脱乙酰酶 (HDAC) 激活剂。 Theophylline sodium glycinate 通过增加 IL-10 和抑制 NF-κB 的核输入而具有抗炎活性。Theophyllin sodium glycinate 可诱导细胞凋亡。 | |||
T34838 |
Theophylline, 7-(2-oxo-4-piperidinobutyl)-6-thio-, hydrochloride
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Theophylline, 7-(2-oxo-4-piperidinobutyl)-6-thio-, hydrochloride is a bioactive chemical. | |||
T32803 |
LJ 278
LJ-278,p-Dimethylamino-benzyl theophylline chlorhydrate,LJ278 |
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LJ-278 is a bioactive chemical. | |||
T8634 |
8-Bromotheophylline
Bromotheophylline,8-溴茶碱 |
Others | Others |
8-Bromotheophylline (Bromotheophylline) 是 Pamabrom 的活性部分,用于 Oxazolo[2,3-f]purinediones 的合成。Oxazolo[2,3-f]purinediones 可用于腺苷 A1和 A2A 受体上的亲和力评估。 | |||
T14958 |
Choline theophyllinate
Oxtriphylline |
Endogenous Metabolite; PDE | Metabolism |
Choline theophyllinate (Oxtriphylline)是茶碱的胆碱盐,是一种小分子PDE抑制剂,可用来治疗免疫系统疾病和呼吸系统疾病,研究哮喘疾病。 | |||
T9319 |
Tosufloxacin
tosufloxacin tosilate,托氟沙星,Ozex,7-(3-Aminopyrrolidin-1-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid |
Others | Others |
Tosufloxacin (Ozex) 是一种喹诺酮类抗菌剂,是茶碱代谢的有效抑制剂。 | |||
T31432 |
Dicarboxidine
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Dicarboxidine can be used in immunochromatographic assay of theophylline in whole blood. | |||
T40907 | Theophyllol | ||
Theophyllol (theophylline sodium acetate) can alter calcium levels in subcellular fractions of rat brain cortex. | |||
T30686L |
Cafedrine HCl
Cafedrine hydrochloride,Akrinor,L-Net |
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Cafedrine HCl is a chemical linkage of norephedrine and theophylline. | |||
T60461 |
Ambuphylline
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Ambuphylline (Bufylline) 是茶碱的衍生物,可能通过抑制磷酸二酯酶发挥作用。Ambuphylline 是一种支气管扩张剂,可用于哮喘和其他肺部疾病的研究。 | |||
T39485 |
NCT-501 hydrochloride
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NCT-501 hydrochloride is a highly potent and selective inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), which is based on theophylline. It effectively inhibits hALDH1A1 with an IC50 value of 40 nM, exhibiting superior selectivity towards hALDH1A1 compared to other ALDH isozymes and dehydrogenases such as hALDH1B1, hALDH3A1, and hALDH2 (with IC50 values exceeding 57 μM). | |||
T70097 | Acefylline piperazine | ||
Acefylline piperazine is a stimulant drug of the xanthine chemical class. It acts as an adenosine receptor antagonist. Acephylline piperazine is a theophylline derivative with a direct bronchodilator action. It has the advantages over theophylline in being far less toxic and producing minimal gastric irritation. It is indicated for the treatment of asthma, emphysema, acute and chronic bronchitis associated with bronchospasm.Acefylline relaxes smooth muscles, relieves bronchospasm & has a stimula... | |||
T70974 |
Cipamfylline
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Cipamfylline is a xanthine, a theophylline analogue, and is a potent and selective inhibitor of phosphodiesterase type 4 (PDE-4). Cipamfylline was tested in patients with a diagnosis of atopic dermatitis and in two human models of acute and chronic irritant contact dermatitis. The outcome of the study revealed that cipamfylline was more effective than vehicle in treating atopic dermatitis, but less effective than a group II steroid, hydrocortisone-17-butyrate both in the treatment of atopic derm... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T1083 |
Theophylline
Theo-24,1,3-Dimethylxanthine,茶碱 |
Endogenous Metabolite; HDAC; PDE; Adenosine Receptor; Autophagy | Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience |
Theophylline (1,3-Dimethylxanthine) 是茶中的甲基黄嘌呤衍生物,具有利尿、平滑肌松弛、支气管扩张、心脏和中枢神经系统兴奋作用。 | |||
T5940 |
Proxyphylline
羟丙茶碱,7-(2-Hydroxypropyl)theophylline |
PDE; Adenosine Receptor | GPCR/G Protein; Metabolism; Neuroscience |
Proxyphylline (7-(2-Hydroxypropyl)theophylline) 是甲基黄嘌呤衍生物,可用作心脏活化剂、血管扩张剂和支气管扩张剂。 | |||
T2205 |
Acefylline
Theophylline-7-acetic acid,茶碱乙酸,Carboxymethyltheophylline,acetyloxytheophylline,Theophyllineacetic acid |
TNF; PAD; PKA; HDAC; PDE; Adenosine Receptor | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience; Tyrosine Kinase/Adaptors |
Acefylline (Theophylline-7-acetic acid) 是黄嘌呤衍生物,是一种腺苷受体拮抗剂。它是蛋白质精氨酸脱亚氨酶 (PAD) 激活剂,也是一种支气管扩张剂,可抑制大鼠肺 cAMP 磷酸二酯酶同工酶。 | |||
T10021 |
1-Methylxanthine
|
Endogenous Metabolite | Metabolism |
1-Methylxanthine 是咖啡因衍生物,是咖啡因和茶碱 (1,3-二甲基黄嘌呤,TP) 在人体尿代谢产物,能够提高肿瘤细胞的放射敏感性。 | |||
TN6339 |
(R)-5-Hydroxy-1,7-diphenylheptan-3-one
(5R)-Dihydroyashabushiketol,(R)-5-羟基-1,7-二苯基-3-庚酮 |
Others | Others |
(R)-5-Hydroxy-1,7-diphenylheptan-3-one ((5R)-Dihydroyashabushiketol) 是从中药材高良姜的根茎中提取的。它抑制茶碱刺激的鼠 B16 黑色素瘤 4A5 细胞中的黑色素生成。 | |||
T8075 |
1,3-Dimethyluric acid
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Endogenous Metabolite | Metabolism |
1,3-Dimethyluric acid 是尿路结石中的嘌呤成分之一,是一种人体茶碱代谢的产物。 | |||
T0480 |
Doxofylline
Doxophylline,多索茶碱 |
PDE; Adenosine Receptor | GPCR/G Protein; Metabolism; Neuroscience |
Doxofylline (Doxophylline) 是腺苷 A1 受体拮抗剂,且能抑制磷酸二酯酶 IV,用于治疗哮喘。 | |||
TN1486 |
Chimonanthine
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Others | Others |
(-)-Chimonanthine (IC50 = 0.93 μM) shows potent inhibitory effects on melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells. |