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3
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11482 | GSK2245035 | Others | Others |
GSK2245035 is a highly selective intranasal TLR7 agonist with preferential Type-1 interferon (IFN)-stimulating properties (pEC50s: 9.3 and 6.5 for IFNα and TFNα). It effectively suppresses allergen-induced Th2 cytokine production in human peripheral blood | |||
T17099 |
Timapiprant sodium
OC000459 sodium |
Others | Others |
Timapiprant sodium inhibits mast cell activation of Th2 lymphocytes and eosinophils. Timapiprant sodium is a potent and selective D prostanoid receptor 2 antagonist. Timapiprant sodium potently displaces [3H] PGD2 from human recombinant DP2 (Ki=13 nM), ra | |||
T82882 |
Binetrakin
|
||
Binetrakin (Interleukin 4 (human)) 是一种多效性细胞因子,源自T淋巴细胞,具有影响包括B细胞和T细胞在内的多种细胞类型的能力。它促进Th0细胞向Th2细胞的分化,广泛应用于各类生物学研究。 | |||
T10890 | CRTh2 antagonist 3 | Others | Others |
CRTh2 antagonist 3 is a powerful chemokine receptor homologous molecule expressed on Th2 cell (CRTh2) antagonists. CRTh2 antagonist 3 enhanced the activity of PDK1 on short peptide substrates with EC50 of 2 μM and Kd of 8.4 μM. CRTh2 antagonist 3 has the | |||
T62860 | YM-341619 | ||
YM-341619 (AS1617612) 是一种有效的、口服具有活力的 STAT6 抑制剂 (IC50: 0.70 nM)。YM-341619 能够抑制 IL-4 诱导的小鼠脾脏 T 细胞 Th2 分化,其 IC50 值为 0.28 nM,但不会影响 Th1 细胞的分化。YM-341619 是一种具有潜力的、能够用于过敏性疾病(如过敏性哮喘)研究的化合物。 | |||
T81314 |
Rademikibart
CBP-201 |
||
Rademikibart (CBP-201) 是一款针对IL-4Rα的人源化单克隆抗体,其与人IL-4Rα的结合亲和力KD值为20.7 pM。该抗体不与其他物种的IL-4Rα发生交互作用。Rademikibart 能够抑制PBMC中IL-4及IL-13介导的STAT6信号通路、TF-1细胞的增殖以及TARC的产生,显示出其在中到重度Th2型炎症性疾病研究中的应用潜力。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TQ0265 |
Indolelactic acid
|
Endogenous Metabolite | Metabolism |
Indolelactic acid 是 Azotobacter vinelandii 培养中的色氨酸分解代谢物。 | |||
T38838 |
QS-21
Stimulon,QS-21 |
||
QS-21, an immunostimulatory saponin, is a powerful vaccine adjuvant that stimulates both Th2 humoral and Th1 cell-mediated immune responses by interacting with antigen presenting cells (APCs) and T cells. Additionally, QS-21 activates the NLRP3 inflammasome, leading to the release of cytokines IL-1β and IL-18, which are dependent on caspase-1. | |||
TN4778 |
Physalin H
|
gp120/CD4; Antifection; Autophagy | Autophagy; Immunology/Inflammation; Microbiology/Virology |
Physalin H is an Hh signaling inhibitor blocks GLI1-DNA-complex formation, it also strong quinone reductase induction activity with IR (Induction ratio, QR induction activity) value of 3.74±0.02. Physalin H shows immunosuppressive effects on T cells both |