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Cat. No. | Product Name | Target | Signaling Pathways |
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T5481 |
TRi-1
|
Others | Others |
TRi-1 是不可逆的胞质硫氧还蛋白还原酶1 的特异性抑制剂(IC50:12 nM)。它有抗肿瘤作用,且线粒体毒性很小。 | |||
T2569 |
Chlorotrianisene
tris(p-methoxyphenyl)chloroethylene,氯丁烯二烯,CTA,tri-p-anisylchloroethylene,氯烯雌醚,TACE |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor; COX | Endocrinology/Hormones; Immunology/Inflammation; Neuroscience |
Chlorotrianisene (tri-p-anisylchloroethylene) 是长效、可口服、亲脂性高的合成三苯乙烯 (TPE) 衍生物和选择性雌激素受体调节剂,有雌激素活性,也有抗雌激素活性。它还有效抑制COX-1并抑制全血中的血小板聚集。 | |||
T18860 |
Tri-(PEG1-C2-acid)
|
Others | Others |
Tri-(PEG1-C2-acid) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
TNU0694 |
2,3,5-Tri-O-benzoyl-1-O-acetyl-4-thio-D-ribofuranose
|
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2,3,5-Tri-O-benzoyl-1-O-acetyl-4-thio-D-ribofuranose is a Carbohydrate. | |||
TNU1292 |
2,3,5-Tri-O-(p-toluoyl)-1-O-acetyl-4-thio-D-ribofuranose
|
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2,3,5-Tri-O-(p-toluoyl)-1-O-acetyl-4-thio-D-ribofuranose is a Carbohydrate Derivative. | |||
TNU0898 |
1-O-Acetyl-2,3,5-tri-O-benzoyl-5(R)-C-methyl-D-ribofuranose
|
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1-O-Acetyl-2,3,5-tri-O-benzoyl-5(R)-C-methyl-D-ribofuranose is a Carbohydrate Derivative. | |||
TNU1045 |
6-Amino-4-methoxy-1-(2,3,5-tri-O-benzoyl-b-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine
|
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6-Amino-4-methoxy-1-(2,3,5-tri-O-benzoyl-b-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 TNU1045。 | |||
TNU1035 |
3,6-Dibromo-1,5-dihydro-1-(2,3,5-tri-O-benzoyl-b-D-ribofuranosyl)-4H-pyrazolo[3,4-d]pyrimidin-4-one
|
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3,6-Dibromo-1,5-dihydro-1-(2,3,5-tri-O-benzoyl-b-D-ribofuranosyl)-4H-pyrazolo[3,4-d]pyrimidin-4-one is a Nucleoside Derivative - 7-Deaza-8-aza-purine nucleoside; Halo-nucleoside; Scaffold and Template. | |||
TNU1033 |
4-Amino-6-bromo-5-cyano-1-(2,3,5-tri-O-benzoyl-b-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine
|
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4-Amino-6-bromo-5-cyano-1-(2,3,5-tri-O-benzoyl-b-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine is a Nucleoside Derivative - 7-Deaza-purine nucleoside, 8-Modified-purine nucleoside, Halo-nucleoside; Scaffold and Template. | |||
T21660L |
b-Casomorphin (1-3) Acetate
b-Casomorphin (1-3) Acetate (72122-59-9 Free base) |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
b-Casomorphin (1-3) Acetate 是一种具有阿片样物质作用的三肽。 | |||
T17161 | Tri(t-butoxycarbonylethoxymethyl) ethanol | Others | Others |
Tri(t-butoxycarbonylethoxymethyl) ethanol, an alkyl/ether-based PROTAC linker, is suitable for synthesizing PROTACs[1]. | |||
T14440 |
Azido-PEG4-amido-tri-(carboxyethoxymethyl)-methane
|
Others | Others |
Azido-PEG4-amido-tri-(carboxyethoxymethyl)-methane is a PEG-based linker compound employed for the synthesis of PROTACs[1]. | |||
T77946 |
Tri-GalNAc(OAc)3
|
LYTACs | PROTAC |
Tri-GalNAc(OAc)3为一tri-GalNAc配体,用于GalNAc-LYTAC合成,该合成物通过靶向去唾液酸糖蛋白受体实施蛋白降解。 | |||
T17160 | Tri(Amino-PEG5-amide)-amine | Others | Others |
Tri(Amino-PEG5-amide)-amine is a polyethylene glycol (PEG) derivative serving as a PEG-based proteolysis targeting chimera (PROTAC) linker, facilitating the synthesis of PROTACs[1]. | |||
T14441 |
Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane
azido-peg4-amido-tri-t-butoxycarbonylethoxymethyl-methane |
Others | Others |
Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane, a PEG-derived PROTAC linker, is employed for PROTAC synthesis[1]. | |||
T16008 |
Maleimido-tri(ethylene glycol)-propionic acid
Mal-PEG3-acid |
Others | Others |
Maleimido-tri(ethylene glycol)-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Maleimido-tri(ethylene glycol)-propionic acid is used for the preparation of neolymphostin-based ADC precursors for site-spec | |||
T77947 |
Tri-GalNAc(OAc)3 TFA
|
LYTACs | PROTAC |
Tri-GalNAc(OAc)3 TFA为一种tri-GalNAc配体,用于GalNAc-LYTAC合成,后者通过靶向去唾液酸糖蛋白受体实现蛋白降解。 | |||
T17444 |
Amino-Tri-(m-PEG4-ethoxymethyl)-methane
|
Others | Others |
Amino-Tri-(m-PEG4-ethoxymethyl)-methane, a PEG-based PROTAC linker, serves as a valuable component for synthesizing PROTACs[1]. | |||
T18859 |
Tri(Mal-PEG2-amide)-amine
|
Others | Others |
Tri(Mal-PEG2-amide)-amine is a polyethylene glycol (PEG)-derived linker commonly employed for synthesizing proteolysis-targeting chimeras (PROTACs)[1]. | |||
T18076 |
m-C-tri(CH2-PEG1-NHS ester)
|
Others | Others |
m-C-tri(CH2-PEG1-NHS ester) is a non-cleavable one-unit polyethylene glycol (PEG) linker employed for the synthesis of antibody-drug conjugates (ADCs)[1]. | |||
T18857 |
Tri(Amino-PEG3-amide)-amine
|
Others | Others |
Tri(Amino-PEG3-amide)-amine is a polyethylene glycol (PEG)-derived linker employed for the synthesis of proteolysis-targeting chimeric molecules (PROTACs)[1]. | |||
T35677 |
2,3,4-Tri-O-acetyl-β-D-Glucuronide methyl ester
|
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2,3,4-Tri-O-acetyl-β-D-glucuronide methyl ester is a synthetic intermediate in the synthesis of prodrug forms of the antitumor antibiotic daunomycin .1 1.Leenders, R.G.G., and Scheeren, H.W.Synthesis and evaluation of novel daunomycin-phosphate-sulfate-β-glucuronide and -β-glucoside prodrugs for application in ADEPTBioorg. Med. Chem. Lett.5(24)2975-2980(1995) | |||
T14256 |
Amino-Tri-(carboxyethoxymethyl)-methane
|
Others | Others |
Amino-Tri-(carboxyethoxymethyl)-methane, an ADC linker and PROTAC linker, is a cleavable PEG compound utilized for the synthesis of antibody-drug conjugates (ADCs)[1] and PEG-based PROTACs[2]. | |||
T77935 |
Tri-GalNAc(OAc)3-Perfluorophenyl
|
LYTACs | PROTAC |
Tri-GalNAc(OAc)3-Perfluorophenyl 为五氟苯基修饰的 Tri-GalNAc(OAc)3,属 tri-GalNAc 配体类,用于 GalNAc-LYTAC 合成。该 GalNAc-LYTAC 通过去唾液酸糖蛋白受体实现靶向蛋白降解。 | |||
T18858 |
Tri(Amino-PEG4-amide)-amine
|
Others | Others |
Tri(Amino-PEG4-amide)-amine is a polyethylene glycol (PEG)-based linker compound utilized for the synthesis of proteolysis-targeting chimeras (PROTACs)[1]. | |||
T80931 |
Tri-valine
NSC 35938 |
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Tri-valine (NSC 35938) 为多肽类化合物,可从肌酸激酶 (Creatine kinase)、β-烯醇化酶、三磷酸异构酶 (Triosephosphate isomerase) 及甘油醛 3-磷酸脱氢酶中分离得到。 | |||
T17165 |
Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine
tris-2-tert-butoxycarbonyl-ethoxy-methyl-methylamine |
Others | Others |
Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine, a cleavable PEG ADC linker, is employed in the synthesis of antibody-drug conjugates (ADCs). It is also a PEG-based PROTAC linker, specifically Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane, widely used in the synthesis of PROTACs[1]. | |||
T77948 |
Tri-GalNAc-DBCO
|
PROTACs | PROTAC |
Tri-GalNAc-DBCO是结合ASGPR以驱动蛋白质下调和靶向蛋白质降解的化合物,其中GalNAc作为肝细胞特异性ASGPR的高亲和力配体。 | |||
T75231 | 9-(5(R)-C-Methyl-2,3,5-tri-O-benzoyl-D-ribofuranosyl)-6-chloropurine | ||
9-(5(R)-C-Methyl-2,3,5-tri-O-benzoyl-D-ribofuranosyl)-6-chloropurine 是一种具有广泛抗肿瘤活性的嘌呤核苷类似物,主要针对惰性淋巴系统的恶性肿瘤。其作用机制涉及抑制 DNA 合成和诱导细胞凋亡(apoptosis)。 | |||
T74388 | Tri(TLR4-IN-C34-PEG2-amide-PEG1)-amide-C3-COOH | ||
Tri(TLR4-IN-C34-PEG2-amide-PEG1)-amide-C3-COOH 是一种含有 TLR4抑制剂 TLR4-IN-C34 的连接子。TLR4-IN-C34 抑制肠细胞和巨噬细胞中的TLR4,减少内毒素血症和坏死性小肠结肠炎小鼠模型的全身炎症。 | |||
T74387 | Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH | ||
Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH为包括TLR4抑制剂TLR4-IN-C34的连接子。该化合物通过抑制肠细胞与巨噬细胞内TLR4活性,能够减轻内毒素血症及坏死性小肠结肠炎小鼠模型中的全身性炎症。 | |||
T80946 |
Tri-GalNAc-NHS ester
|
LYTACs | PROTAC |
Tri-GalNAc-NHS ester 是一种LYTAC,特别作为asialoglycoprotein receptor (ASGPR) 的配体,后者是肝细胞特有、参与细胞外包括膜蛋白在内的蛋白质降解的溶酶体靶向受体。该化合物在利用LYTAC进行蛋白质降解研究中扮演关键角色。 | |||
T77914 |
Amino-Tri-(carboxyethoxymethyl)-methane hydrochloride
|
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Amino-Tri-(carboxyethoxymethyl)-methan hydrochloride 是一种 PEG 类的可降解(cleavable)ADC linker,用于抗体偶联药物(ADC)的合成。同时,该化合物也作为 PEG 类的 PROTAC linker,用于PROTAC分子的合成。 | |||
T64630 | Methanesulfonato(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II) | ||
Methanesulfonato(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II) 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T64630,CAS号为 1445085-55-1。 | |||
T77941 |
tri-GalNAc biotin
|
LYTACs | PROTAC |
tri-GalNAc biotin是一种针对降解物的小分子溶酶体靶向化合物,作为ASGPR(肝脏糖蛋白受体)的配体,它促进肝细胞通过ASGPR吸收中性抗生物素蛋白(NA),并将其运送至溶酶体内降解。该化合物适用于LYTAC(溶酶体靶向嵌合体)的研究。 | |||
T77199 |
Methionylserine
|
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Methionylserine (H-MET-SER-OH) 是一种含有蛋氨酸和丝氨酸的二肽。Methionylserine 可与肠道二/三肽转运蛋白 1 (hPEPT1) 结合并易位,Km 值为 0.2 mM。Methionylserine 抑制ACE 酶的活性。Methionylserine 可用于高血压的研究。 | |||
T73983 | Cidofovir diphosphate tri(triethylamine) | ||
Cidofovir diphosphate tri triethylamine 是西多福韦的细胞内活性代谢物。diphosphate tri triethylamine 是病毒 DNA 聚合酶的选择性抑制剂,对 HCMV,HSV-1和 HSV-2的 Ki 值分别为 6.6,0.86 和 1.4 μM。 | |||
T74389 | Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH | ||
Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH 是一种融合了TLR4-IN-C34抑制剂的连接子。这种抑制剂在阻断肠细胞与巨噬细胞内的TLR4上发挥作用,有效减轻了内毒素血症及坏死性小肠结肠炎小鼠模型中的全身性炎症现象。 | |||
T75131 |
RMC-6291
|
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RMC-6291 是一种口服有效的KRASG12C(ON)共价抑制剂。RMC-6291 在 KRASG12C(ON) 和亲环蛋白 A (CypA) 之间的肿瘤细胞内形成三复合物。因此,RMC-6291 通过空间阻断RAS 效应子结合来阻止 KRASG12C(ON) 发出信号。RMC-6291 在 KRASG12C 肿瘤模型中对RAS 通路活性产生了深度和持久抑制。 | |||
T35515 |
3-Acetyldeoxy Nivalenol-13C17
3-Acetyldeoxy Nivalenol-13C17 |
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3-Acetyldeoxy nivalenol-13C17is intended for use as an internal standard for the quantification of 3-acetyldeoxy nivalenol by GC- or LC-MS. 3-Acetyldeoxy nivalenol is a mycotoxin that has been found inF. graminearum.1In vivo, 3-acetyldeoxy nivalenol (40 mg/kg) induces duodenal and splenic cell necrosis, as well as lethality (LD50= 70 mg/kg) in mice.2 1.Jiao, F., Kawakami, A., and Nakajima, T.Effects of different carbon sources on trichothecene production and Tri gene expression by Fusarium grami... |
Cat. No. | Product Name | Target | Signaling Pathways |
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TN5443 |
Kaempferol 3,4',7-triacetate
Kaempferol 3,4,7-triacetate,3,7-Bis(acetyloxy)-2-[4-(acetyloxy)phenyl]-5-hydroxy-4H-1-benzopyran-4-one,3,7,4'-Tri-O-acetylkaempferol,[4-(3,7-diacetyloxy-5-hydroxy-4-oxochromen-2-yl)phenyl] acetate |
Others | Others |
Kaempferol 3,4',7-triacetate (3,7,4'-Tri-O-acetylkaempferol) 是椴木草本植物的天然产物。 | |||
TN6553 |
N1,N5,N10-(E)-tri-p-coumaroylspermidine
|
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N1,N5,N10-(E)-tri-p-coumaroylspermidine shows free radical-scavenging activity. | |||
T83478 | 1,2,6-Tri-O-galloyl-β-D-glucose | ||
1,2,6-Tri-O-galloyl-β-D-glucose 是可以从Sanguisorba officinalis中提取的化合物。 |