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Cat. No.	Product Name	Target	Signaling Pathways
T61407	TRPC3/6-IN-1
	TRPC3/6-IN-1 is a highly potent and selective inhibitor that specifically blocks the activity of the canonical transient receptor channels TRPC3 and TRPC6. It exhibits a significant blocking potency against the human isoforms hTRPC3 and hTRPC6, with IC50 values of 1260 nM and 500 nM, respectively. This compound, TRPC3/6-IN-1, is particularly valuable for conducting research on chronic models of heart failure [1].
T79054	TRPC3/6-IN-2
	TRPC3/6-IN-2为针对TRPC3及TRPC6的高效抑制剂，IC50分别为16 nM对TRPC3与29.8 nM对TRPC6。
T16686	Pyr10	TRP/TRPV Channel	Membrane transporter/Ion channel
	Pyr10 是吡唑衍生物，是TRPC3通道的选择性抑制剂。Pyr10抑制卡巴可刺激的TRPC3转染的 HEK293 细胞中的 Ca2+流入。它具有区分受体操纵的TRPC3和天然基质相互作用分子 1 (STIM1)/Orai1 通道的能力。
T16687	Pyr3	TRP/TRPV Channel	Membrane transporter/Ion channel
	Pyr3 是一种选择性瞬时受体电位经典通道 3 抑制剂。 Pyr3 以剂量依赖性方式抑制 TRPC3 介导的 Ca2+ 内流 (IC50 = 700 nM)。
T16688	Pyr6 N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide	TRP/TRPV Channel	Membrane transporter/Ion channel
	Pyr6 (N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide)是选择性的 TRPC3抑制剂，IC50值为0.49uM。
TP2158	TRV-120027 TFA TRV-120027 TFA (1234510-46-3 free base)	RAAS; Arrestin	Endocrinology/Hormones; GPCR/G Protein
	TRV-120027 TFA 是一种血管紧张素 II 介导的血管收缩抑制剂，可增加心肌细胞的收缩力。它是一种偏向 β-arrestin-1 的 AT1R 激动剂，可与 ß-arrestins 结合，同时阻断 G 蛋白信号传导。它通过阳离子通道亚家族 C3 (TRPC3) 偶联诱导急性儿茶酚胺分泌，并促进在质膜上形成由 AT1R-β-arrestin-1-TRPC3-PLCγ 组成的大分子复合物。
T16532	Pico145 HC-608	TRP/TRPV Channel	Membrane transporter/Ion channel
	Pico145 (HC-608) 是有效的瞬时受体电位通道蛋白 1/4/5 (TRPC1/TRPC4/TRPC5) 抑制剂，在细胞中，抑制 (-)-englerin A 活化TRPC4/TRPC5 通道的IC50分别为 0.349 和 1.3 nM。
T10537	BI-749327	TRP/TRPV Channel	Membrane transporter/Ion channel
	BI-749327是高选择性、口服有效的TRPC6拮抗剂，对小鼠、人、豚鼠 TRPC6 作用的IC50值分别为 13 nM、19 nM 和 15 nM。BI-749327对小鼠 TRPC6 选择性比 TRPC3 高出 85 倍，比TRPC7高出42 倍。
T8784	IGS-1.76	Others	Others
	IGS-1.76对hNCS-1有显著的亲和力，并有效调节hNCS-1与Ric8a之间的相互作用。此外，IGS-1.76还能熟练抑制由human NCS-1和Ric8a形成的复合物。
T28444	PPZ1 PPZ 1,PPZ-1
	PPZ1 is a novel DAG-activated TRPC3/TRPC6/TRPC7 channels activator.
T28445	PPZ2 PPZ-2,PPZ 2
	PPZ2 is a novel DAG-activated TRPC3/TRPC6/TRPC7 channels activator.
T33814	OptoDArG Opto-DArG,Opto DArG
	OptoDArG is a diacylglycerol (DAG) photoswitch, which enables efficient control of TRPC3 by light.
T38780	GSK2332255B
	GSK2332255B is a highly potent and selective TRPC3 and TRPC6 antagonist, exhibiting IC50 values of 5 nM and 4 nM for rat TRPC3 and rat TRPC6, respectively. Furthermore, GSK2332255B demonstrates exceptional selectivity, surpassing a ≥100-fold difference when compared to other calcium-permeable channels.
T37698	OptoBI-1
	OptoBI-1 是一种光敏分子，是光致变色的TRPC3激动剂，可用作控制神经元放电的光药理学工具。
T15425	GSK1702934A	Others	Others
	GSK1702934A is a selective TRPC3 agonist. It modulates cardiac contractility and f arrhythmogenesis by activation of TRPC3.
T37823	M 084 hydrochloride
	TRPC4/5 channel blocker (IC50 values are 3.7-10.3 and 8.2 μM, respectively). Also weakly blocks TRPC3 channels. Exhibits rapid antidepressant and anxiolytic effects in vivo. Zhu et al (2015) Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels. Br.J.Pharmacol. 172 3495 PMID:25816897 \|Yang et al (2015) Acute treatment with a novel TRPC4/C5 channel inhibitor produces antidepressant and anxiolytic-like effects in mice. PLoS One 10 e0136...
T41232	GSK 2833503A
	GSK 2833503A is a potent and selective TRPC6 and TRPC3 antagonist (IC50 = 3-16 nM and 21-100 nM, respectively). GSK 2833503A exhibits >63-fold selectivity over other ion channels, including other TRP channels, CaV1.2, hERG and NaV1.5. GSK 2833503A suppresses angiotensin II or endothelin-1-induced cardiac hypertrophy signaling in HEK293 cellsin vitroand in cardiomyocytes.
T71303	Flufenamic Acid-d4
	Flufenamic acid-d4 is intended for use as an internal standard for the quantification of flufenamic acid by GC- or LC-MS. Flufenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 3 and 9.3 µM for human COX-1 and COX-2, respectively). Flufenamic acid inhibits TNF-α-induced increases in COX-2 levels and NF-κB activation in HT-29 colon cancer cells in a concentration-dependent manner. It inhibits calcium influx induced by fMLP or A23187 in human polymorphonuclear...
T13213	TRPC6-IN-1	Others	Others
	TRPC6-IN-1 is an inhibitor of the Transient Receptor Potential Canonical 6 Channel (TRPC6) (EC50: 4.66 μM).
T23148	Phenamil methanesulfonate Phenamil	Others	Others
	TRPP3 channel inhibitor

化合物

Cat.No: T61407

Cat.No: T79054

Cat.No: T16686

Target: TRP/TRPV Channel

Cat.No: T16687

Target: TRP/TRPV Channel

Cat.No: T16688

Synonym: N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide

Target: TRP/TRPV Channel

Cat.No: TP2158

Synonym: TRV-120027 TFA (1234510-46-3 free base)

Target: RAAS, Arrestin

Cat.No: T16532

Synonym: HC-608

Target: TRP/TRPV Channel

Cat.No: T10537

Target: TRP/TRPV Channel

Cat.No: T8784

Target: Others

Cat.No: T28444

Synonym: PPZ 1,PPZ-1

Cat.No: T28445

Synonym: PPZ-2,PPZ 2

Cat.No: T33814

Synonym: Opto-DArG,Opto DArG

Cat.No: T38780

Cat.No: T37698

Cat.No: T15425

Target: Others

M 084 hydrochloride

Cat.No: T37823

Cat.No: T41232

Flufenamic Acid-d4

Cat.No: T71303

Cat.No: T13213

Target: Others

Phenamil methanesulfonate

Cat.No: T23148

Synonym: Phenamil

Target: Others

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