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17

抑制剂 & 化合物

1

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Cat. No.	Product Name	Target	Signaling Pathways
T17146	TPO agonist 1	Others	Others
	TPO agonist 1 is a thrombopoietin agonist. It would be useful as promoters of thrombopoiesis and megakaryocytopoiesis to treat thrombocytopenia.
T2562	Eltrombopag SB-497115,SB-497115-GR,艾曲波帕	Thrombin	Proteases/Proteasome
	Eltrombopag (SB-497115-GR) 是一种具有巨核细胞生成刺激活性的口服活性血小板生成素受体激动剂，可结合并刺激血小板血小板生成素受体，用于血小板减少的某些病症研究。
T6825	Eltrombopag Olamine Promacta Olamine,Revolade,艾曲泊帕乙醇胺盐,Eltrombopag diethanolamine salt,SB497115,艾曲波帕乙醇胺盐,SB-497115GR	Thrombin	Proteases/Proteasome
	Eltrombopag Olamine (Eltrombopag diethanolamine salt) 是 Eltrombopag 的口服活性乙醇胺盐，是一种血小板生成素(TPO)受体激动剂，用于血小板减少的某些病症研究。
T7417	Avatrombopag YM477,AKR-501,1-[3-氯-5-[[[4-(4-氯-2-噻吩基)-5-(4-环己基-1-哌嗪基)-2-噻唑基]氨基]羰基]-2-吡啶基]-4-哌啶羧酸,E5501	Thrombin; Thrombopoietin Receptor	Immunology/Inflammation; Proteases/Proteasome
	Avatrombopag (YM477) 是一种新型口服血小板生成素 (TPO) 受体激动剂，可激活 TPO 受体并增加巨核细胞增殖/分化和血小板生成。
T3473	(S)-ATPO ATPO	GluR	Neuroscience
	(S)-ATPO 是 GluR1-4 (AMPA-preferring) 受体的竞争性拮抗剂。
T17147	TPOP146	Epigenetic Reader Domain	Chromatin/Epigenetic
	TPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor (Kd: 134 nM and 5.02 μM for CBP and BRD4).
TQ0223	Lusutrombopag 芦曲泊帕,鲁索曲波帕,S-888711,Mulpleta	Thrombin; Thrombopoietin Receptor	Immunology/Inflammation; Proteases/Proteasome
	Lusutrombopag (Mulpleta) 是一种口服生物可利用的小分子血小板生成素 (TPO) 受体激动剂，用于选择性侵入性手术前患有血小板减少症的慢性肝病的患者。
T67894	Butyzamide	Thrombopoietin Receptor; JAK	Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Stem Cells
	Butyzamide 是一种有效的可口服的Mpl 激活剂，是一种对血小板生成素(TPO)受体具有拮抗作用的新型非肽基分子，促进表达人Mpl (hMpl)的和小鼠pro B 细胞株Ba/F3的增殖，诱导JAK2、STAT3、STAT5和MAPK 的磷酸化。Butyzamide 在小鼠异种移植试验中有助于提升血小板水平。
T40654	Avatrombopag hydrochloride AKR-501 hydrochloride,YM477hydrochloride,E5501hydrochloride
	Avatrombopag hydrochloride (AKR-501) is an orally active, nonpeptide agonist of the thrombopoietin (TPO) receptor with an EC 50 of 3.3 nM. It effectively mimics the biological activities of TPO, stimulating platelet production by activating the intracellular signaling system and facilitating the generation of platelets and megakaryocytes from hemopoietic precursor cells. Additionally, Avatrombopag hydrochloride serves as a substrate for cytochrome P450 (CYP) 2C9 and CYP3A.
T62865	Rafutrombopag
	Rafutrombopag 是一种血小板生成素 (TPO) 激动剂。
T27536	Hetrombopag olamine
	Hetrombopag olamine is a non-peptide thrombopoietin (TPO) receptor agonist with oral activity.
T68560	Totrombopag choline
	Totrombopag, also known LGD-4665, GSK2285921 and SB559448, is an oral thromobopoietin receptor agonist, is being developed as a new generation small molecule thrombopoietin (TPO) mimetic. It is a highly selective and potent agonist of the TPO receptor and therefore induces differentiation and proliferation of megakaryocytes. The pharmacologic characteristics indicate potential therapeutic use in thrombocytopenic patients with a variety of clinical etiologies.
T68888	Avatrombopag maleate
	Avatrombopag, also known as AKR-501, YM477, AS 1670542 or E5501, is a novel orally-active thrombopoietin (TPO) receptor agonist. AKR-501 specifically targeted the TPO receptor and stimulated megakaryocytopoiesis throughout the development and maturation of megakaryocytes just as rhTPO did. AKR-501 may be useful in the treatment of patients with thrombocytopenia. Avatrombopag was first approved in 2018.
T72265	Eltrombopag methyl ester
	Eltrombopag methyl ester，一种Eltrombopag衍生物，为促血小板生成素(Tpo)受体激动剂，旨在促进血小板生成，用于研究特定类型的血小板减少症。
T38602	(E/Z)-Eltrombopag 13C4 (E/Z)-Eltrombopag 13C4,(E/Z)-SB-497115 13C4
	(E/Z)-Eltrombopag 13C4 ((E/Z)-SB-497115 13C4) is a mixture complex of E-Eltrombopag and Z-Eltrombopag, with 13C labeled. Z-Eltrombopag is a thrombopoietin (TPO) receptor agonist developed for certain conditions that lead to thrombocytopenia.
T60281	MPO-IN-4
	MPO-IN-4 (compound 12) 是一种有效的选择性髓过氧化物酶 (MPO) 抑制剂，IC50为 25 nM。MPO-IN-4对甲状腺过氧化物酶(TPO)也显示抑制作用，IC50为2.2 μM。MPO-IN-4 对甲基鸟嘌呤甲基转移酶 (MGMT) 没有影响。
T40137	MPO-IN-1
	MPO-IN-1 is a powerful and orally bioavailable indole-containing inhibitor that acts irrevocably on myeloperoxidase (MPO). With IC50 values of 2.6 μM and 5.3 μM for MPO and thyroid peroxidase (TPO), respectively, MPO-IN-1 effectively inhibits both enzymes. Furthermore, it exhibits remarkable MPO inhibitory activity in an acute inflammation mouse model.

化合物

TPO agonist 1

Cat.No: T17146

Target: Others

Cat.No: T2562

Synonym: SB-497115,SB-497115-GR,艾曲波帕

Target: Thrombin

Eltrombopag Olamine

Cat.No: T6825

Synonym: Promacta Olamine,Revolade,艾曲泊帕乙醇胺盐,Eltrombopag diethanolamine salt,SB497115,艾曲波帕乙醇胺盐,SB-497115GR

Target: Thrombin

Cat.No: T7417

Synonym: YM477,AKR-501,1-[3-氯-5-[[[4-(4-氯-2-噻吩基)-5-(4-环己基-1-哌嗪基)-2-噻唑基]氨基]羰基]-2-吡啶基]-4-哌啶羧酸,E5501

Target: Thrombin, Thrombopoietin Receptor

Cat.No: T3473

Synonym: ATPO

Target: GluR

Cat.No: T17147

Target: Epigenetic Reader Domain

Cat.No: TQ0223

Synonym: 芦曲泊帕,鲁索曲波帕,S-888711,Mulpleta

Target: Thrombin, Thrombopoietin Receptor

Cat.No: T67894

Target: Thrombopoietin Receptor, JAK

Avatrombopag hydrochloride

Cat.No: T40654

Synonym: AKR-501 hydrochloride,YM477hydrochloride,E5501hydrochloride

Cat.No: T62865

Hetrombopag olamine

Cat.No: T27536

Totrombopag choline

Cat.No: T68560

Avatrombopag maleate

Cat.No: T68888

Eltrombopag methyl ester

Cat.No: T72265

(E/Z)-Eltrombopag 13C4

Cat.No: T38602

Synonym: (E/Z)-Eltrombopag 13C4,(E/Z)-SB-497115 13C4

Cat.No: T60281

Cat.No: T40137

Cat. No.	Product Name	Target	Signaling Pathways
T3882	4”-O-Glucosylvitexin glucosylvitexin,牡荆素葡萄糖苷	Thrombopoietin Receptor	Immunology/Inflammation
	4”-O-Glucosylvitexin (glucosylvitexin) 是一种黄酮类化合物，提取自山楂叶中，具有生物活性。

天然产物

4”-O-Glucosylvitexin

Cat.No: T3882

Synonym: glucosylvitexin,牡荆素葡萄糖苷

Target: Thrombopoietin Receptor

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