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Search Results for " tgf-β2 "

Targets Recommended: TGF-beta/Smad

5

抑制剂 & 化合物

1

化合物库

9

重组蛋白

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Cat. No.	Product Name
L4100	TGF-β/Smad靶点化合物库		184 compounds
	184 个 TGF-β/Smad 靶点相关的小分子化合物的特有集合，用于高通量、高内涵筛选；

化合物库

TGF-β/Smad靶点化合物库

Cat.No: L4100

Compounds: 184

Cat. No.	Product Name	Target	Signaling Pathways
T3636	(E)-SIS3 SIS3,SIS3 盐酸盐,SIS3 HCl	TGF-beta/Smad	Stem Cells
	(E)-SIS3 (SIS3) 是 Smad3 的选择性抑制剂，能够抑制 Smad3 磷酸化(IC50:3 μM)。它利用 TGF-β1 抑制成纤维细胞向肌成纤维细胞分化。
T2386	Pirfenidone S-7701,AMR-69,S-7701,AMR69,吡非尼酮	CCR; TGF-beta/Smad	Immunology/Inflammation; Microbiology/Virology; Stem Cells
	Pirfenidone (AMR69) 是一种抗纤维化剂，可减弱纤维细胞中CCL2和CCL12的产生。它可抑制细胞生长，并能降低人胶质瘤细胞系中的TGF-β2蛋白水平，具有抗炎活性。
T74204	Trabedersen
	Trabedersen (AP 12009) 是一种反义寡脱氧核苷酸，可特异性抑制 TGF-β2(TGF-beta/Smad)。Trabedersen 可用于研究恶性脑肿瘤和其他过度表达 TGF-β2的实体瘤，例如皮肤、胰腺和结肠肿瘤。
T77057	Lerdelimumab
	Lerdelimumab (CAT-152) 为人源IgG4抗TGF-β2重组单克隆抗体，主要研究用途包括作为青光眼治疗的抗结疤剂。
T71119	Netarsudil free base
	Netarsudil, also known as AR-11324, is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and/or reducing intraocular pressure. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Netarsudil inhibited kinases ROCK1 and ROCK2 with a Ki of 1 nM each, disrupted actin stress fibers and focal adhesions in TM cells with IC50s of 79 and 16 nM, respectively, and blocked the profibrotic effects of TGF-β2 in HTM cells. Netarsudi...

化合物

Cat.No: T3636

Synonym: SIS3,SIS3 盐酸盐,SIS3 HCl

Target: TGF-beta/Smad

Cat.No: T2386

Synonym: S-7701,AMR-69,S-7701,AMR69,吡非尼酮

Target: CCR, TGF-beta/Smad

Cat.No: T74204

Cat.No: T77057

Netarsudil free base

Cat.No: T71119

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00413	Latent TGF beta 2 Protein, Mouse, Recombinant (His) Tgfb-2,Tgf-beta2,TGF-beta 2,T...	Mouse	HEK293 Cells
	TGF beta 2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.9 kDa and the accession number is P27090.
TMPJ-00261	TGF beta 2 Protein, Mouse/Rat, Recombinant transforming growth factor β-2,BSC-1 cell growth inhibitor,G...	Mouse,Rat	HEK293 Cells
	Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital systems. All TGF-β isoforms signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the n...
TMPJ-00258	TGF beta 2 Protein, Human, Recombinant Glioblastoma-derived T-cell suppressor factor,TGF-β...	Human	HEK293 Cells
	Transforming growth factor beta-2 (TGF-β2) is a secreted protein which belongs to the TGF-beta family. It is known as a cytokine that performs many cellular functions and has a vital role during embryonic development. The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive. It is an extracellular glycosylated protein. It is known to suppress the effects of interleukin dependent T-cell tumors. Defects in TGFB2 may be...
TMPY-04577	TGF beta 2 Protein, Rhesus, Recombinant (His) TGF-beta 2,transforming growth factor beta 2,transf...	Rhesus	HEK293 Cells
	TGF beta 2 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47 kDa and the accession number is F6ZJW6.
TMPY-05314	TGF beta 2 Protein, Mouse, Recombinant (His), Biotinylated transforming growth factor β2,TGF β2	Mouse	HEK293 Cells
	TGF beta 2 Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.9 kDa and the accession number is P27090.
TMPY-00231	TGF beta 2 Protein, Canine, Recombinant (His) transforming growth factor β2,转化生长因子,TGF-b...	Canine	HEK293 Cells
	TGF beta 2 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47 kDa and the accession number is A0A8C0RRP5.
TMPJ-00260	Latent TGF-beta 2 Protein, Human, Recombinant (His & Avi), Biotinylated TGFB2,TGF-β-2,TGF-beta-2,Transfor...	Human	HEK293 Cells
	Latent TGF-beta 2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-8xHis-Avi tag. The predicted molecular weight is 13 and 39-50 KDa and the accession number is P61812.
TMPJ-00259	TGF beta 2 Protein, Human, Recombinant (Avi), Biotinylated G-TSF,转化生长因子,Cetermin,Transforming growth factor beta-2 prop...	Human	HEK293 Cells
	TGF beta 2 Protein, Human, Recombinant (Avi), Biotinylated is expressed in HEK293 mammalian cells with N-Avi tag. The predicted molecular weight is 10-14 KDa and the accession number is P61812.
TMPJ-00771	TGF beta 1 Protein, Mouse/Rat, Recombinant TGFB,TGFbeta,CEDLAP,TGF-beta-1,	Mouse,Rat	HEK293 Cells
	Transforming growth factor beta 1 (TGFβ1) is the prototype of a growing superfamily of peptide growth factors and plays a prominent role in a variety of cellular processes, including cell-cycle progression, cell differentiation, reproductive function, development, motility, adhesion, neuronal growth, bone morphogenesis, wound healing, and immune surveillance. TGF-β1, TGF-β2 and TGF-β3 signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II)...

重组蛋白

Latent TGF beta 2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00413

Species: Mouse

Expression System: HEK293 Cells

TGF beta 2 Protein, Mouse/Rat, Recombinant

Cat.No: TMPJ-00261

Species: Mouse,Rat

Expression System: HEK293 Cells

TGF beta 2 Protein, Human, Recombinant

Cat.No: TMPJ-00258

Species: Human

Expression System: HEK293 Cells

TGF beta 2 Protein, Rhesus, Recombinant (His)

Cat.No: TMPY-04577

Species: Rhesus

Expression System: HEK293 Cells

TGF beta 2 Protein, Mouse, Recombinant (His), Biotinylated

Cat.No: TMPY-05314

Species: Mouse

Expression System: HEK293 Cells

TGF beta 2 Protein, Canine, Recombinant (His)

Cat.No: TMPY-00231

Species: Canine

Expression System: HEK293 Cells

Latent TGF-beta 2 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPJ-00260

Species: Human

Expression System: HEK293 Cells

TGF beta 2 Protein, Human, Recombinant (Avi), Biotinylated

Cat.No: TMPJ-00259

Species: Human

Expression System: HEK293 Cells

TGF beta 1 Protein, Mouse/Rat, Recombinant

Cat.No: TMPJ-00771

Species: Mouse,Rat

Expression System: HEK293 Cells

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