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Cat. No.	Product Name	Target	Signaling Pathways
T7951	TBK1/IKKε-IN-5	IκB/IKK	NF-κB
	TBK1/IKKε-IN-5 是一种 TBK1 (IC50:1 nM) 和 IKKε (IC50:5.6 nM) 的双抑制剂。
T15559	TBK1/IKKε-IN-2	IκB/IKK	NF-κB
	TBK1/IKKε-IN-2 是双重TBK1和IKKε抑制剂。
T0097	MRT67307 MRT67307 HCl	IκB/IKK; Autophagy	Autophagy; NF-κB
	MRT67307 是一种IKKε和TBK-1的双抑制剂，IC50分别为 160 和 19 nM。它抑制细胞自噬，也可抑制ULK1和ULK2，IC50分别为 45 和 38 nM。
T13097	TBK1/IKKε-IN-1	IκB/IKK	NF-κB
	TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM).
T36247	TBK1 control PROTAC® 4
	Negative control for TBK1 PROTAC 3i. Binds TBK1 with high affinity, but exhibits no significant degradation of TBK1. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.
T38263	TBK1/IKKε-IN-4 TBK1/IKKε-IN-4
	TBK1/IKKε-IN-4 is a 6-aminopyrazolopyrimidine derivative and a potent, selective TBK1 and IKKε inhibitor with IC50 values of 13 nM and 59 nM, respectively. TBK1/IKKε-IN-4 shows 100- to 1000-fold less activity against other protein kinases including PDK1, PI3K family members and mTOR[1]. TBK1/IKKε-IN-4 (Compound II; 96 hours; A549 andHCC44 cells) treatmentdisplays selective toxicity in TBK1-dependent cancer cell lines (IC50 of ~ 4.2 μM for H441 cells and IC50 of ~0.4 μM for A549 cells)[1].TBK1/IK...
T39841	TBK1/IKKε-IN-6 TBK1/IKKε-IN-6
	TBK1/IKKε-IN-6 (example 110) is a potent inhibitor of TBK1 and IKKε, with IC50 values of less than 100 nM for both enzymes.
T36994	MRT 67307 dihydrochloride	SIK	PI3K/Akt/mTOR signaling
	MRT 67307 dihydrochloride 是 IKKε 和 TBK-1 的双抑制剂，IC50 分别为 160 和 19 nM。MRT 67307 dihydrochloride 也可抑制 ULK1 和 ULK2，IC50 分别为 45 和 38 nM。MRT 67307 dihydrochloride 还抑制细胞自噬 (autophagy)。
T61550	DMX-129
	DMX-129 是一种ΙΚΚε和TBK-1抑制剂，IC50均小于 30 nM。
T23028	MRT67307 HCl (1190378-57-4 free base) MRT67307 HCl	Others	Others
	MRT67307 is an inhibitor for TBK1, IKKε , MARK1-4 and NUAK1 with IC50 value of 19, 160, 27-52 and 230nM , respectively [1]. It is an inhibitor for ULK1and ULK2 with IC50 value of 45 and 38nM, respectively [2]. Also, it is a salt inducible kinase (SIK) inhibitor with IC50 value of 250, 67 and 430nM for SIK1, SIK2 and SIK3, respectively.<br />SIKs prevent the formation of regulatory macrophages and their inhibition induces increasing in some markers of regulatory macrophages, such as IL-10 and oth...