Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5162 |
MRT67307 HCl (1190378-57-4(free base))
盐酸MRT67307 |
IκB/IKK; AMPK; Autophagy | Autophagy; Chromatin/Epigenetic; NF-κB; PI3K/Akt/mTOR signaling |
MRT67307 HCl (1190378-57-4(free base)) 是 TBK1、MARK1-4、IKKε 和 NUAK1 的激酶抑制剂(IC50 分别为 19、27-52、160 和 230 nM)。 | |||
T36994 |
MRT 67307 dihydrochloride
|
SIK | PI3K/Akt/mTOR signaling |
MRT 67307 dihydrochloride 是 IKKε 和 TBK-1 的双抑制剂,IC50 分别为 160 和 19 nM。MRT 67307 dihydrochloride 也可抑制 ULK1 和 ULK2,IC50 分别为 45 和 38 nM。MRT 67307 dihydrochloride 还抑制细胞自噬 (autophagy)。 | |||
T23028 |
MRT67307 HCl (1190378-57-4 free base)
MRT67307 HCl |
Others | Others |
MRT67307 is an inhibitor for TBK1, IKKε , MARK1-4 and NUAK1 with IC50 value of 19, 160, 27-52 and 230nM , respectively [1]. It is an inhibitor for ULK1and ULK2 with IC50 value of 45 and 38nM, respectively [2]. Also, it is a salt inducible kinase (SIK) inhibitor with IC50 value of 250, 67 and 430nM for SIK1, SIK2 and SIK3, respectively.<br />SIKs prevent the formation of regulatory macrophages and their inhibition induces increasing in some markers of regulatory macrophages, such as IL-10 and oth... | |||
T0097 |
MRT67307
MRT67307 HCl |
IκB/IKK; Autophagy | Autophagy; NF-κB |
MRT67307 是一种IKKε和TBK-1的双抑制剂,IC50分别为 160 和 19 nM。它抑制细胞自噬,也可抑制ULK1和ULK2,IC50分别为 45 和 38 nM。 |