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Search Results for " sterol biosynthesis "

15

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T20237	Fenhexamid Elevate,Teldor,环酰菌胺	Antifungal	Microbiology/Virology
	Fenhexamid (Elevate) 是一种甾醇生物合成抑制剂，对植物病原真菌具有抗真菌活性。 Fenhexamid 用于农业，并在水果和蔬菜中以可测量的量存在。
T20691	Fenpropidin 苯锈啶,Ro12-3049,Ro-12-3049,Ro 12-3049	Antifungal	Microbiology/Virology
	Fenpropidin (Ro-12-3049) 是甾醇类生物合成的抑制剂，具有杀菌的活性。
T0506	Clotrimazole 克霉唑,BAY b 5097,FB 5097	Antibacterial; Antibiotic; Antifection; Autophagy; Antifungal	Autophagy; Microbiology/Virology
	Clotrimazole (FB 5097) 是咪唑衍生物，有抗真菌和抗菌活性，是 P450抑制剂。
T21482	Uniconazole	P450; ROS Kinase	Metabolism; Tyrosine Kinase/Adaptors
	Uniconazole 是植物生长调节剂，能够抑制细胞色素 P450 707As (Ki=68 nM)。他是分解脱落酸的酶家族成员，能够抑制赤霉素和甾醇的生物合成。
T1543	Naftifine hydrochloride Naftifungin,盐酸萘替芬,Naftifine HCl,Naftin,Exoderil	Hedgehog/Smoothened; Antibiotic; Antifungal	GPCR/G Protein; Microbiology/Virology; Stem Cells
	Naftifine hydrochloride (Naftifine HCl) 是一种抗生素。它具有抗真菌活性，对皮肤真菌、曲霉、Sporothrix schenckii、假丝酵母属的酵母有抑制作用。
T14362	AY 9944	Others	Others
	AY 9944 是特异性的胆固醇生物合成抑制剂。它抑制 7- 脱氢胆固醇 Δ7- 还原酶 (IC50:13 nM)，导致胆固醇不足和 7DHC 积累。在高剂量下，它可在培养的胚胎中抑制固醇 Δ7-Δ8 异构酶，造成胆固醇 8-en-3β-ol 的积累。
T15708	Lanoconazole	Antifungal	Microbiology/Virology
	Lanoconazole is an orally active imidazole antifungal agent that displays a broad spectrum of activity against fungi in vitro and in vivo. Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis.
T22559	Alendronate sodium	Others	Others
	The compound binds and blocks farnesyl diphosphate synthase in the HMG-CoA pathway (IC50 = 460 nM for recombinant human FPPS). It causes macrophage apoptosis and inhibits prenylation and sterol biosynthesis in purified osteoclasts.
T73807	Geranyl diphosphate
	Geranyl diphosphate 是IBP(类异戊二烯生物合成途径)的关键中间体，在细胞代谢中扮演至关重要的角色，主要负责甾醇和非甾醇类异戊二烯的生成。
T68219	Peraclopone
	Peraclopone is a hypolidemic drug. It is an inhibitor of 7-Dehydrocholesterol reductase. Peraclopone potently inhibits the final step in cholesterol biosynthesis. Feeding this agent to rats leads to a rapid replacement of membrane cholesterol with its immediate precursor 7-dehydrocholesterol, and a dramatic reduction in plasma sterol concentration. Peraclopone caused a dose-dependent decrease in cholesterol and a concomitant accumulation of provitamin D3 (7-dehydrocholesterol) in the skin, which...
T9802	Penconazole
	Penconazole 是一种典型的三唑类杀菌剂 (fungicide)，主要用于苹果、葡萄、蔬菜等的白粉病防治。Penconazole 抑制真菌甾醇生物合成。Penconazole 降低大鼠大脑和小脑AChE 活性。
T60853	(Z)-Lanoconazole
	(Z)-Lanoconazole 是 Lanoconazole 的 Z 构型，用于研究皮肤癣菌病和甲癣。Lanoconazole 抑制甾醇 14-α脱甲基酶并阻断真菌膜上的麦角甾醇生物合成，从而干扰麦角甾醇的生物合成。Lanoconazole 是具有口服活性的咪唑类抗真菌剂，在体外和体内均具有广谱的抗真菌活性。
T37322	Steryl Glucosides
	Steryl glucosides are neutral glycolipids commonly found in plant cell membranes and vegetable oils that contain a glucose moiety conjugated to a sterol lipid. They function as glucose donors in the biosynthesis of glucocerebrosides in plant microsomes and are metabolic precursors to acylated/esterified steryl glucosides. Steryl glucosides are the major component of filter- and engine-damaging precipitates formed during biodiesel production from transesterification of vegetable oils. This produ...
T41322	Dimethomorph
	Dimethomorph 是一种吗啉类杀菌剂，属于甾醇生物合成抑制剂类杀菌剂，可抑制真菌细胞壁的形成。Dimethomorph 抑制了oomycete fungi，P. citrophthora，P. parasitica，P. capsici，和P. infestans 的菌丝生长 (EC50=0.14 μg/mL，0.38 μg/mL，<0.1 μg/mL 和 0.16-0.3 μg/mL)，但是对绿藻物种C. vulgaris 和S. obliquus 的活性较低 (EC50=47.46 μg/mL 和 44.87 μg/mL)。在 MDA-kb2 人乳腺癌细胞的报告基因分析中，Dimethomorph 抑制雄激素受体 (AR) 的活性，而在酵母抗雄激素筛选中不起作用 (IC20=0.263 μM 和 38.5 μM)。
T35665	Pregnanetriol
	Pregnanetriol is a metabolite of 17α-hydroxyprogesterone .1,2It is formed from 17α-hydroxyprogesterone by reduction of the C-20 ketone.2Urinary levels of pregnanetriol are elevated in patients with 21-hydroxylase deficiency and congenital adrenal hyperplasia.3,4 1.Kamrath, C., Hartmann, M.F., Boettcher, C., et al.Diagnosis of 21-hydroxylase deficiency by urinary metabolite ratios using gas chromatography-mass spectrometry analysis: Reference values for neonates and infantsJ. Steroid Biochem. Mol...

化合物

Cat.No: T20237

Synonym: Elevate,Teldor,环酰菌胺

Target: Antifungal

Cat.No: T20691

Synonym: 苯锈啶,Ro12-3049,Ro-12-3049,Ro 12-3049

Target: Antifungal

Cat.No: T0506

Synonym: 克霉唑,BAY b 5097,FB 5097

Target: Antibacterial, Antibiotic, Antifection, Autophagy, Antifungal

Cat.No: T21482

Target: P450, ROS Kinase

Naftifine hydrochloride

Cat.No: T1543

Synonym: Naftifungin,盐酸萘替芬,Naftifine HCl,Naftin,Exoderil

Target: Hedgehog/Smoothened, Antibiotic, Antifungal

Cat.No: T14362

Target: Others

Cat.No: T15708

Target: Antifungal

Alendronate sodium

Cat.No: T22559

Target: Others

Geranyl diphosphate

Cat.No: T73807

Cat.No: T68219

Cat.No: T9802

(Z)-Lanoconazole

Cat.No: T60853

Steryl Glucosides

Cat.No: T37322

Cat.No: T41322

Cat.No: T35665

Cat. No.	Product Name	Target	Signaling Pathways
T4717	25-Hydroxycholesterol 25-羟基胆固醇,25-羟基胆甾醇	Others; Endogenous Metabolite; HMG-CoA Reductase	Metabolism; Others
	25-Hydroxycholesterol 是胆固醇的代谢产物，由巨噬细胞响应 Toll 样受体激活而分泌。它有效抑制 B 细胞产生 IgA，EC50约为 65 nM。
T10910	Cycloartenol	Others	Others
	Cyclopentanol is a plant sterol compound and one of the key precursors for biosynthesis of various sterol compounds. Cycloartenol inhibits the migration of glioma cells and inhibits the phosphorylation of p38 MAP kinase. Cycloenol has various pharmacologi

天然产物

25-Hydroxycholesterol

Cat.No: T4717

Synonym: 25-羟基胆固醇,25-羟基胆甾醇

Target: Others, Endogenous Metabolite, HMG-CoA Reductase

Cat.No: T10910

Target: Others

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