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Cat. No.	Product Name	Target	Signaling Pathways
T0476	Spironolactone 安体舒通,螺内酯,SC9420,Abbolactone	Glucocorticoid Receptor; Androgen Receptor; Autophagy	Autophagy; Endocrinology/Hormones
	Spironolactone (SC9420) 是一种可口服的醛固酮盐皮质激素受体拮抗剂，IC50值为 24 nM。它也是雄激素受体拮抗剂，促进足细胞自噬，IC50值为 77 nM。
T29480	7alpha-Thiospironolactone Deacetylspironolactone
	7α-Thio Spironolactone is a Spironolactone (sc-204294) metabolite.
T37362	7α-Thiomethylspironolactone
	7α-Thiomethylspironolactone is a major metabolite of the synthetic steroid spironolactone.1,2 1.Jankowski, A., Skorek-Jankowska, A., and Lamparczyk, H.Simultaneous determination of spironolactone and its metabolites in human plasmaJ. Pharm. Biomed. Anal.14(8-10)1359-1365(1996) 2.Gardiner, P., Schrode, K., Quinlan, D., et al.Spironolactone metabolism: Steady-state serum levels of the sulfur-containing metabolitesJ. Clin. Pharmacol.29(4)342-347(1989)
T1541	Drospirenone ZK 3059,屈螺酮,Dihydrospirorenone	Glucocorticoid Receptor; Estrogen/progestogen Receptor; Progesterone Receptor; Androgen Receptor; COX	Endocrinology/Hormones; Immunology/Inflammation; Neuroscience; Others
	Drospirenone (ZK 3059) 是spironolactone 的类似物，是一种合成的孕酮。
T71664	Mespirenone	Others	Others
	Mespirenone 是一种具有利尿作用的螺内酯衍生物和醛固酮拮抗剂。
T68765	Spirorenone
	Spirorenone is an androstadienone derivative as a highly effective aldosterone antagonist. Spirorenone is 8.6 times as potent as spironolactone, but showed a lower affinity for the mineralocorticoid receptors. In phase I clinical trials Spirorenone was absorbed with a half-life of 20-30 min, achieving maximum concentrations of about 100 ng/ml (10 mg) and 260 ng/ml (40 mg) after 1-2 h. Disposition of the parent drug was biphasic with half-lives of 50-60 min (distribution) and 5-6 h (elimination)....

化合物

Spironolactone

Cat.No: T0476

Synonym: 安体舒通,螺内酯,SC9420,Abbolactone

Target: Glucocorticoid Receptor, Androgen Receptor, Autophagy

7alpha-Thiospironolactone

Cat.No: T29480

Synonym: Deacetylspironolactone

7α-Thiomethylspironolactone

Cat.No: T37362

Cat.No: T1541

Synonym: ZK 3059,屈螺酮,Dihydrospirorenone

Target: Glucocorticoid Receptor, Estrogen/progestogen Receptor, Progesterone Receptor, Androgen Receptor, COX

Cat.No: T71664

Target: Others

Cat.No: T68765

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