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Cat. No.	Product Name	Target	Signaling Pathways
T81148	Smac-based peptide
	Smac-based peptide为具有生物活性的肽，源自SMAC与BIR3结构域的结合。
T6763	Xevinapant ARRY-334543,SM-406,AT406,Debio-1143	IAP	Apoptosis
	Xevinapant (Debio-1143) 是一种有效的 Smac 模拟物和 IAP 的拮抗剂，能够抑制 XIAP，cIAP1 和 cIAP2 蛋白，Ki 值分别为 66.4，1.9 和 5.1 nM。
T3299	Xevinapant hydrochloride AT-406 HCl,SM-406	Apoptosis; IAP	Apoptosis
	Xevinapant hydrochloride (AT-406 HCl) 是口服生物可利用的 Smac 模拟物，也是细胞凋亡蛋白抑制剂的拮抗剂。它在无细胞功能测定中有效拮抗 XIAP BIR3 蛋白，诱导细胞 cIAP1 蛋白的快速降解，并抑制各种人类癌细胞系中的癌细胞生长。它在诱导异种移植肿瘤细胞凋亡方面非常有效。
T20053	Jasmacyclen EC 226-501-6,NSC-6598,Verdyl acetate,Greenyl acetate,NS 6598,NSC 6598
	Jasmacyclen is a compound in which has an aroma.
T35205	Xylosmacin
	Xylosmacin is a biochemical.
T2080	LCL161	IAP	Apoptosis
	LCL161 是一种 SMAC 模拟物，可有效结合并抑制多种 IAP。它抑制 HEK293 细胞中 XIAP 和 MDA-MB-231细胞中 cIAP1的 IC50分别为 35 和 0.4 nM。
T6007	Birinapant TL32711,比瑞那帕	Apoptosis; IAP; HIV Protease	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Birinapant (TL32711) 是一种二价 Smac 模拟物，是 XIAP 和 cIAP1的强效拮抗剂，Kd 值分别为 45 nM 和小于 1 nM。它靶向与 TRAF2 相关的 cIAP，并消除 TNF 诱导的 NF-κB 活化。
T12932L	SM-164	Apoptosis; IAP	Apoptosis
	SM-164 是细胞渗透性 Smac 类似物，与含有 BIR2 和 BIR3 结构域的 XIAP 蛋白结合，IC50值为 1.39 nM，它用作XIAP 的强效拮抗剂。
T26242	SW IV-52 SW-IV-52,SW IV52,SW IV 52,SWIV52
	SW IV-52 is an XIAP-inhibitor that acts as a second mitochondria-derived activator of caspases (SMAC) mimetic.
T63969	SM-433
	SM-433 是 Smac 模拟物，是凋亡抑制蛋白(IAPs)的抑制剂。SM-433 对 XIAP BIR3 蛋白具有较强的亲和力 (IC50<1 μM)。
T64217	SM-433 hydrochloride
	SM-433 hydrochlorid 是一种 Smac 模拟物，是一种凋亡抑制蛋白(IAPs)抑制剂。SM-433 hydrochlorid 能够强力结合 XIAP BIR3 蛋白 (IC50<1 μM)。
T15723	LBW242	Others	Others
	LBW242 is a 3-mer and Smac mimetic and is an effective and orally active proapoptotic IAP inhibitor. LBW242 has activity against multiple myeloma and potentiates TRAIL- and anticancer drug-mediated cell death of ovarian cancer cells. LBW242 displays effec
T75243	SM-164 Hydrochloride
	SM-164 Hydrochloride 是一种可渗透细胞的 Smac 类似物。SM-164 与含有 BIR2 和 BIR3 结构域的XIAP 蛋白结合，IC50值为 1.39 nM，SM-164 用作XIAP 的强效拮抗剂。
T12932	SM-164 Hydrochloride (957135-43-2 free base) SM-164 Hydrochloride	IAP	Apoptosis
	SM-164 Hydrochloride is a cell-permeable Smac mimetic compound. SM-164 binds to XIAP protein containing both the BIR2 and BIR3 domains(IC50 value of 1.39 nM) and functions as an extremely potent antagonist of XIAP.
T38857	SBP-0636457 SBI-0636457,SB1-0636457,SBP-0636457
	SBP-0636457 (SB1-0636457) is a SMAC mimetic and an inhibitor of inhibitor of apoptosis (IAP) proteins. It specifically binds to the BIR-domains of IAP proteins with a Ki value of 0.27 μM. SBP-0636457 holds potential for research in the fields of solid tumors and hematologic cancers.
T36201	AZD5582 dihydrochloride AZD 5582 dihydrochloride
	Dimeric Smac mimetic; potent inhibitor of X-linked (XIAP) and cellular (cIAP) inhibitor of apoptosis protein (IC50 values are 15, 15 and 21 nM for XIAP, cIAP1 and cIAP2 respectively). Binds to the BIR3 domain of XIAP to prevent interaction with caspase-9. Causes degradation of cIAP1 and cIAP2 and induces apoptosis in MDA-MB-231 breast cancer cells. Causes tumor regression in MDA-MB-231 xenograft-bearing mice. Hennessy et al (2013) Discovery of a novel class of dimeric Smac mimetics as potent IAP...
T69323	Dexamethasone sodium succinate
	Dexamethasone sodium succinate is the acetate salt form of dexamethasone, which is a synthetic glucocorticoid; it combines high anti-inflammatory effects with low mineralocorticoid activity. At high doses (e.g. 40 mg), it reduces the immune response. Dexamethasone acetate (NEOFORDEX®) is indicated in adults for the treatment of symptomatic multiple myeloma in combination with other medicinal products. Dexamethasone has been shown to induce multiple myeloma cell death (apoptosis) via a down-regul...
T69200	CGP74514A
	CGP74514A is a CDK1 inhibitor with potential anticancer activity. In U937 cells, CGP74514A - induced apoptosis (5 microM) became apparent within 4 hr and approached 100% by 24 hr. The pan- caspase inhibitor Boc-fmk and the caspase-8 inhibitor lETD-fmk opposed CGP74514A -induced caspase-9 activation and PARP degradation, but not cytochrome c or Smac/DIABLO release. CGP74514A -mediated apoptosis was substantially blocked by ectopic expression of full-length Bel- 2, a loop-deleted mutant Bcl-2, and...

化合物

Smac-based peptide

Cat.No: T81148

Cat.No: T6763

Synonym: ARRY-334543,SM-406,AT406,Debio-1143

Target: IAP

Xevinapant hydrochloride

Cat.No: T3299

Synonym: AT-406 HCl,SM-406

Target: Apoptosis, IAP

Cat.No: T20053

Synonym: EC 226-501-6,NSC-6598,Verdyl acetate,Greenyl acetate,NS 6598,NSC 6598

Cat.No: T35205

Cat.No: T2080

Target: IAP

Cat.No: T6007

Synonym: TL32711,比瑞那帕

Target: Apoptosis, IAP, HIV Protease

Cat.No: T12932L

Target: Apoptosis, IAP

Cat.No: T26242

Synonym: SW-IV-52,SW IV52,SW IV 52,SWIV52

Cat.No: T63969

SM-433 hydrochloride

Cat.No: T64217

Cat.No: T15723

Target: Others

SM-164 Hydrochloride

Cat.No: T75243

SM-164 Hydrochloride (957135-43-2 free base)

Cat.No: T12932

Synonym: SM-164 Hydrochloride

Target: IAP

Cat.No: T38857

Synonym: SBI-0636457,SB1-0636457,SBP-0636457

AZD5582 dihydrochloride

Cat.No: T36201

Synonym: AZD 5582 dihydrochloride

Dexamethasone sodium succinate

Cat.No: T69323

Cat.No: T69200

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