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13

抑制剂 & 化合物

1

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Cat. No.	Product Name	Target	Signaling Pathways
T28410	PHPS1 PHPS-1,PHPS 1	Phosphatase	Metabolism
	PHPS1 是 Shp2的选择性抑制剂，对 Shp2，Shp2-R362K，Shp1，PTP1B 和 PTP1B-Q 的 Ki 分别为 0.73，5.8，10.7，5.8 和 0.47 μM。
T16350	NSC-87877	Apoptosis; Phosphatase	Apoptosis; Metabolism
	NSC-87877 是一种Shp2和Shp1蛋白质酪氨酸磷酸酶抑制剂，IC50值分别为0.318 μM 和0.355 μM。它还抑制双特异性磷酸酶26。
T4627	SPI--112Me	Others	Others
	SPI--112Me 是 SPI-112 的前药，在无细胞试验中，它优先抑制 Shp2 的 PTPase 活性超过 Shp1 和 PTP1B 20 倍。
T73552	BPDA2
	BPDA2为高选择性竞争性SHP2活性位点抑制剂，SHP2的IC50为92.0 nM, 对SHP1及SHP1B的IC50则分别为33.39 μM与40.71 μM。该化合物降低了有丝分裂促进因子、细胞存活信号以及RTK的表达，并抑制了SHP2介导的信号传导，影响乳腺癌细胞表型。
T6911	NSC-87877 disodium NSC87877	Apoptosis; Phosphatase	Apoptosis; Metabolism
	NSC-87877 disodium (NSC87877) 是一种有效的Shp2和Shp1蛋白质酪氨酸磷酸酶抑制剂，IC50值分别为0.318 μM 和0.355 μM。NSC-87877还抑制双特异性磷酸酶26。
T3962	TPI-1 TPI 1,TPI1	Phosphatase; Glucocorticoid Receptor	Endocrinology/Hormones; Metabolism
	TPI-1 是一种 SHP-1的抑制剂，其 IC50=40 nM。
T39167	GS-493
	GS-493, a highly specific protein tyrosine phosphatase SHP2 (PTPN11) inhibitor, exhibits remarkable potency with an IC50 of 71 nM. It displays 29- and 45-fold greater affinity towards SHP2 compared to its related counterparts, SHP1 and PTP1B, respectively. In addition, GS-493 impedes both cellular motility and growth of cancer cells, portraying promising antitumor effects.
T25953	PHPS1 Sodium PHPS1 Na,PHPS1 Sodium salt
	PHPS1 sodium 是 Shp2的选择性抑制剂，对 Shp2，Shp2-R362K，Shp1，PTP1B 和 PTP1B-Q 的Ki 值分别为 0.73，5.8，10.7，5.8 和 0.47 μM。
T7541	PTP inhibitor 1 PTP Inhibitor II,alpha-溴-4-甲氧基苯乙酮	Phosphatase	Metabolism
	PTP inhibitor 1 是蛋白酪氨酸磷酸酶 (PTP) 抑制剂，具有抗血管生成作用。
T61701	SHP2-IN-9
	SHP2-IN-9 is a potent inhibitor (IC50 = 1.174 μM) specifically targeting the SHP2 protein, displaying improved penetration across the blood-brain barrier. It exhibits a remarkable 85-fold selectivity for SHP2 over SHP1. By inhibiting SHP2-mediated cell signal transduction and impairing cancer cell proliferation, SHP2-IN-9 effectively suppresses the growth of both cervix cancer tumors and glioblastoma in vivo [1].
T7084	2-Bromo-4'-hydroxyacetophenone SHP-1 Inhibitor II,PTP Inhibitor I,α-Bromo-4-hydroxyacetophenone,4-Hydroxyphenacyl bromide,2-溴-4'-羟基苯乙酮	Phosphatase	Metabolism
	2-Bromo-4'-hydroxyacetophenone(PTP Inhibitor I) 是一种PTP1B 的有效抑制剂，其Ki=42 μM。
T38834	LYP-IN-1
	LYP-IN-1 is a powerful LYP inhibitor that demonstrates high potency, selectivity, and specificity, with a Ki of 110 nM and an IC 50 of 0.259 μM. Beyond its primary target, LYP-IN-1 also exhibits selectivity towards a wide range of PTPs, including SHP1 (IC 50 = 5 μM) and SHP2 (IC 50 = 2.5 μM). Additionally, LYP-IN-1 demonstrates remarkable efficacy in T- and mast cells, making it a valuable tool for investigating autoimmune disorders.
T35940	Darinaparsin Dimethylarsinic glutathione,Darinaparsin
	Darinaparsin is a dimethylated arsenic linked to glutathione. It is cytotoxic to DU145, LNCaP, and PC3 prostate cancer cells (IC50s = 5-10 &#181M) and patient-derived primary prostate cancer cells (IC50s = 2.5-20 &#181M), as well as Jurkat T cell lymphoma and L540 Hodgkin lymphoma cells (IC50s = 2.7 and 1.3 &#181M, respectively). [1][2] It decreases the tumor-initiating subpopulation in DU145 and PC3 cells and halts the cell cycle in the G2/M phase. Darinaparsin decreases transcription of Gli-2,...

化合物

Cat.No: T28410

Synonym: PHPS-1,PHPS 1

Target: Phosphatase

Cat.No: T16350

Target: Apoptosis, Phosphatase

Cat.No: T4627

Target: Others

Cat.No: T73552

NSC-87877 disodium

Cat.No: T6911

Synonym: NSC87877

Target: Apoptosis, Phosphatase

Cat.No: T3962

Synonym: TPI 1,TPI1

Target: Phosphatase, Glucocorticoid Receptor

Cat.No: T39167

Cat.No: T25953

Synonym: PHPS1 Na,PHPS1 Sodium salt

PTP inhibitor 1

Cat.No: T7541

Synonym: PTP Inhibitor II,alpha-溴-4-甲氧基苯乙酮

Target: Phosphatase

Cat.No: T61701

2-Bromo-4'-hydroxyacetophenone

Cat.No: T7084

Synonym: SHP-1 Inhibitor II,PTP Inhibitor I,α-Bromo-4-hydroxyacetophenone,4-Hydroxyphenacyl bromide,2-溴-4'-羟基苯乙酮

Target: Phosphatase

Cat.No: T38834

Cat.No: T35940

Synonym: Dimethylarsinic glutathione,Darinaparsin

Cat. No.	Product Name	Target	Signaling Pathways
T79985	Cryptosporioptide A	Phosphatase	Metabolism
	Cryptosporioptide A (Compound 3)是一种从昆虫寄生真菌Cordyceps gracilioides中分离出的色素蛋白酪氨酸磷酸酶抑制剂，针对PTP1B、SHP2、CDC25B、LAR和SHP1等酶展示了抑制作用，其IC50值分别为7.3、5.7、7.6、>50、4.9 μg/mL。

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Cryptosporioptide A

Cat.No: T79985

Target: Phosphatase

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