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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13009 |
STAT3-IN-1
|
Apoptosis; STAT | Apoptosis; JAK/STAT signaling; Stem Cells |
STAT3-IN-1 是一种选择性的、口服有效的 STAT3的强效抑制剂,可诱导肿瘤细胞凋亡,其在 HT29 和MDA-MB 231 细胞中的IC50值分别为1.82 μM 和2.14 μM。 | |||
T28865 |
STAT3-IN-B9
STAT3 IN B9,B9 |
STAT | JAK/STAT signaling; Stem Cells |
STAT3-IN-B9 (B9) 是异常 STAT3 激活的抑制剂,可抑制 MDA-MB-468、MDA-MB-231 和 DU145 等肿瘤细胞的增殖。 | |||
T13010 |
STAT3-IN-3
|
STAT | JAK/STAT signaling; Stem Cells |
STAT3-IN-3 is a potent and selective signal transducer inhibitor and transcription 3 (STAT3) activator. | |||
T72120 |
Guanosine 5'-diphosphate sodium
GDP sodium |
||
Guanosine 5'-diphosphate (GDP) sodium 是一种核苷二磷酸,可激活 5'-三磷酸腺苷敏感的 K+通道。Guanosine 5'-diphosphate sodium 是一种潜在的铁动员剂,可阻断铁调素-铁转运蛋白 (hepcidin-ferroportin) 相互作用并调节 IL-6/stat-3通路。Guanosine 5'-diphosphate sodium 可用于炎症研究,如炎症性贫血 (AI)。 | |||
T68536 |
WP-1034
|
||
WP-1034 is a novel Jak-Stat inhibitor, which is active against AML blasts. WP-1034 effectively inhibited proliferation of OCIM2 cells and fresh AML samples. WP-1034 caused cell cycle arrest of OCIM2 cells in sub-Go phase. WP-1034 induced apoptosis of OCIM2 cells and that induction of apoptosis involved cleavage of caspase 3 and the DNA repair enzyme poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP). | |||
T37265 |
15(R)-Lipoxin A4
15(R)-Lipoxin A4,AT-Lipoxin A4 |
||
Lipid-derived lipoxins are produced at the site of vascular and mucosal inflammation where they down-regulate polymorphonuclear leukocyte recruitment and function. 15(R)-Lipoxin A4 (15(R)-LXA4) is derived from the aspirin-triggered formation of 15(R)-HETE from arachidonic acid. [1] [2] 15(R)-LXA4 inhibits LTB4-induced chemotaxis, adherence, and transmigration of neutrophils with twice the potency of LXA4 demonstrating activity in the nM range.[2] [3] The anti-inflammatory effects of aspirin may... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1237 |
3-O-Methylgallic acid
3,4-Dihydroxy-5-methoxybenzoic acid,3-O-甲基没食子酸 |
Apoptosis; NF-κB; OCT; DNA/RNA Synthesis; STAT | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; JAK/STAT signaling; Membrane transporter/Ion channel; NF-κB; Stem Cells |
3-O-Methylgallic acid (3,4-Dihydroxy-5-methoxybenzoic acid) 是一种花青素代谢产物,具有强大的抗氧化能力。它还诱导细胞凋亡并具有抗癌作用,可抑制 Caco-2 细胞增殖,IC50值为 24.1 μM。 | |||
T6S1966 |
Curculigoside
Curculigoside A,仙茅苷 |
Antioxidant; NF-κB; JAK; STAT | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; NF-κB; oxidation-reduction; Stem Cells |
Curculigoside (Curculigoside A) 是仙茅中的主要皂苷,具有显著的抗氧化、抗骨质疏松、抗抑郁和神经保护作用。它通过调节JAK/STAT/NF-κB 信号传导途径,具有抗关节炎作用。 |