Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T16807 |
Rucaparib monocamsylate
瑞卡帕布樟脑磺酸盐,Rucaparib Camsylate |
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Rucaparib monocamsylate (Rucaparib Camsylate) 是一种口服有效的 PARP 蛋白抑制剂,对 PARP-1 的Ki 为 1.4 nM。它是六磷酸己糖脱氢酶 (H6PD) 抑制剂,有用于去势抵抗性前列腺癌 (CRPC) 的研究潜力。 | |||
T4463 |
Rucaparib
AG-14447,PF-01367338,瑞卡帕布,AG014699 |
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Rucaparib (PF-01367338) 是一种口服有效的 PARP 蛋白抑制剂,对 PARP-1 的 Ki 为 1.4 nM。它是六磷酸己糖脱氢酶 (H6PD) 抑制剂,有用于去势抵抗性前列腺癌 (CRPC) 的研究潜力。 | |||
T6127 |
Rucaparib Phosphate
AG-014699 phosphate,PF-01367338,芦卡帕利,AG-014699,瑞卡帕布磷酸盐,PF-01367338 phosphate |
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Rucaparib Phosphate (PF-01367338 phosphate) 是一种口服有效的PARP 蛋白抑制剂,对 PARP-1 的Ki 为 1.4 nM。它是六磷酸己糖脱氢酶 (H6PD) 抑制剂,有用于去势抵抗性前列腺癌 (CRPC) 的研究潜力。 | |||
T8440 |
LASSBio-1135
|
TNF; TRP/TRPV Channel | Apoptosis; Membrane transporter/Ion channel |
LASSBio-1135 是一种口服有效的 TRPV1 拮抗剂和 TNF-α 生成抑制剂。 | |||
T70164 |
LASSBio-1829 HCl
|
||
LASSBio-1829 HCl is an orally active IKK2 inhibitor. | |||
T24388 |
LASSBio-1359
LASSBio1359,LASSBio 1359 |
||
LASSBio-1359 is an adenosine receptor agonist. It acts by inducing relaxation of the corpus cavernosum. It also acts as a novel selective phosphodiesterase. | |||
T61794 | LASSBio-1632 | ||
LASSBio-1632 is a novel anti-asthmatic lead candidate that selectively inhibits PDE4A and PDE4D isoenzymes, leading to the suppression of airway hyper-reactivity (AHR) and TNF-α production in lung tissue. With high experimental BBB permeability, LASSBio-1632 (7j) efficiently crosses the blood-brain barrier through passive diffusion [1]. | |||
T24389 |
LASSBio-1366
LASSBio 1366 |
||
LASSBio-1366 is an agonist of adenosine A2a receptor that acts by attenuating the progression of monocrotaline-induced pulmonary hypertension. | |||
T32582 |
LASSBio-881
LASSBio881,LASSBio 881 |
||
LASSBio-881 is a non-selective partial agonist of the CB1 and CB2 cannabinoid receptors, as well as an antagonist of the TRPV1 receptor. | |||
T9430 |
Venadaparib
NOV140101,IDX-1197 |
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Venadaparib (NOV140101) 是一种选择性和具有口服活性的 PARP 抑制剂,对 PARP1和 PARP2的 IC50分别为 1.4 和 1.0 nM。它可防止 DNA 单链断裂 (SSB) 的修复,可研究实体瘤。 | |||
T9756 |
AZD-9574
|
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
AZD-9574 是 SSB 位点的 PARP1 特异性抑制剂。 AZD-9574 具有抗癌活性,可用于 HRD+ 乳腺癌和晚期实体恶性肿瘤的研究。 |