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抑制剂 & 化合物

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Cat. No. Product Name Target Signaling Pathways
T26202 SP-Chymostatin B

alpha-Mapi
SP-Chymostatin B is a potent inhibitor of many proteases, including chymotrypsin, papain, chymotrypsin-like serine proteinases, chymases, and lysosomal cysteine proteinases. It weakly inhibits human leucocyte elastase. It is effective at a final concentra
T80296 SP-B peptide

SP-B peptide 是具有抗真菌活性的抗菌肽，有效针对新型隐球菌、白色念珠菌及烟曲霉菌株。
T8685 SP-146

Aurora Kinase Cell Cycle/Checkpoint; Chromatin/Epigenetic
SP-146 是一种选择性、有效且非 ATP 竞争性的 Aurora B 抑制剂（IC50：0.316 nM）。
T41256 SP-96

Aurora Kinase Cell Cycle/Checkpoint; Chromatin/Epigenetic
SP-96 是一种高效的特异性 Aurora B 抑制剂，IC50 为 0.316 nM。 SP-96 在 NCI60 筛选中显示特异性生长抑制，如 MDA-MD-468 (GI50=107 nM)。 SP-96 可用于三阴性乳腺癌研究。
T36520 COR659

Cannabinoid Receptor; GABA Receptor GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
COR659 是一种有效的 GABAB 的阳性变构调节剂。COR659具有缓解大鼠对酒精和巧克力成瘾的作用。
T32848 Lokysterolamine B

N-Acetyl-4beta-hydroxy-epi-plakinamine A
Lokysterolamine B is a steroidal alkaloid isolated from a sponge, Corticium sp.
T23957 Dactylocycline B

Dactylocyclines B is a novel tetracycline derivative produced by a Dactylosporangium sp. A screen for antibiotics with activity against tetracycline-resistant microorganisms has led to the isolation of Dactylosporangium sp.
T40457 Cinerubin B

Cinerubin B is a glycosylated anthracycline antibiotic that exhibits anticancer activity. It is derived from Streptomyces sp. SPB74.
T38302 Chrysomycin B

Chrysomycin B 是分离自链霉菌的一种抗生素 。Chrysomycin B 能引起人肺腺癌 A549 细胞系的 DNA 损伤，并抑制拓扑异构酶 II。
T38694 Sp-8-CPT-cAMPS

Sp-8-CPT-cAMPS is a powerful and specific cAMP analog that activates cAMP-dependent protein kinase A (PKA I and PKA II) selectively and effectively. It exhibits a 153-fold preference for site A of RI over site A of RII, and a 59-fold preference for site B of RII over site B of RI.
T37542 Anguinomycin A

Anguinomycin A is an antibiotic first isolated from a Streptomyces sp. and analog of leptomycin B that is highly cytotoxic to mouse P388 leukemia cells in vitro (IC50 = 0.1-0.2 ng/ml). It also demonstrates antitumor activity at 62.5 μg/kg/day against Lewis lung carcinoma in mice.
T22707 Dalfopristin (mesylate) (112362-50-2 free base)

Dalfopristin (mesylate)

 Others Others
Dalfopristin (mesylate) is a streptogramin antibiotic and a 50S ribosome inhibitor. Streptogramins are produced by a variety of Streptomyces sp as a mixture (ratio of 7:3) of two chemically unrelated compounds, type A and B. Dalfopristin, the type A Strep
T37540 Amycolatopsin B

Amycolatopsin B is a bacterial metabolite originally isolated fromAmycolatopsisthat has anticancer activity.1It is cytotoxic to NCI H460 lung and SW620 colon cancer cells (IC50s = 0.28 and 0.14 μM, respectively). 1.Khalil, Z.G., Salim, A.A., Vuong, D., et al.Amycolatopsins A-C: Antimycobacterial glycosylated polyketide macrolides from the Australian soil Amycolatopsis sp. MST-108494J. Antibiot. (Tokyo)70(12)1097-1103(2017)
T37288 Remisporine B

Remisporine B is a polyketide and derivative of remisporine A that has been found inPenicilliumand has immunosuppressant activity.1,2It inhibits LPS- or concanavalin A-induced proliferation of isolated mouse splenic lymphocytes (IC50s = 30.1 and 32.4 μg/ml, respectively).1 1.Liu, H., Chen, S., Liu, W., et al.Polyketides with immunosuppressive activities from mangrove endophytic fungus Penicillium sp. ZJ-SY2Mar. Drugs14(12)217(2016) 2.Kong, F., and Carter, G.T.Remisporine B, a novel dimeric chrom...
T35742 IKD-8344

IKD-8344 is a macrocyclic dilactone originally isolated from an actinomycete species and has diverse biological activities, including anticancer, antimicrobial, and anthelmintic properties.1,2,3 It is cytotoxic to L5178Y murine leukemia cells (IC50 = 0.54 ng/ml).1 IKD-8344 inhibits growth of the mycelial form of C. albicans (MIC = 6.25 μg/ml) and potentiates the activity of polymyxin B against the multidrug-resistant pathogenic bacterium B. cenocepacia.2,3 It is active against T. spiralis in vit...
T36748 Heliquinomycin

Heliquinomycin is a bacterial metabolite originally isolated fromStreptomycesthat has diverse biological activities.1It is active against a variety of Gram-positive bacteria, including strains ofB. anthracis, B. subtilis, and methicillin-sensitive or -resistantS. aureus(MICs = <0.05-0.39 μg/ml). Heliquinomycin inhibits the activity of DNA helicase with a Kivalue of 6.8 μM. It reduces the growth of L1210 leukemia, B16 melanoma, and FS-3 fibrosarcoma cells (IC50s = 0.97, 0.89, and 0.83 μg/ml, resp...
T37536 Carbazomycin A

Carbazomycin A is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities.1,2It is active againstS. aureus,T. asteroides, andT. mentagrophytes(MIC = 12.5 μg/ml for all), as well as the plant pathogenic fungusP. oryzae(MIC = 25 μg/ml). Carbazomycin A is cytotoxic to MCF-7, KB, NCI H187, and Vero cells (IC50s = 26.2, 30.1, 18.4, and 32.6 μg/ml, respectively).2 1.Sakano, K.-I., Ishimaru, K., and Nakamura, S.New antibiotics, carbazomycins A and B. I. Fermenta...
T37553 (-)-Mycousnine

(-)-Mycousnine is a microbial metabolite and derivative of usnic acid originally isolated fromM. nawaethat has antibacterial and antifungal activities.1,2It is active against the Gram-positive bacteriaB. subtilis,K. rhizophila, andS. aureus(MICs = 4, 8, and 4 g/ml, respectively) but not the Gram-negative bacteriaE. coli,S. typhimurium, andK. pneumoniae(MICs = >128 g/ml for all).2(-)-Mycousnine is also active against the fungiT. mentagrophytes,T. rubrum, andC. albicans(MICs = 25, 25, and 100 μg/m...
T35978 Benastatin A

Benastatin A is a polyketide synthase-derived benastatin that has been found inStreptomycesand has diverse biological activities.1,2,3It inhibits glutathione S-transferase (GST; Ki= 5 μM for the rat liver enzyme).2Benastatin A is active against several bacteria, including methicillin-resistantS. aureus(MRSA; MIC = 3.12 μg/ml). It induces apoptosis and cell cycle arrest at the G1/G0phase in Colon 26 mouse colon cancer cells when used at concentrations of 20 and 16 μM, respectively.3 1.Xu, Z., Sch...
T35909 Penicinoline

Penicinoline is an alkaloid that has been found in Penicillium and has antimalarial, insecticidal, and anticancer activities.1,2 It is active against chloroquine-sensitive and -resistant strains of P. falciparum (IC50 = 25 μM for both).1 Penicinoline (1,000 ppm) is also active against the aphid A. gossypii.2 It inhibits proliferation of 95-D and HepG2 cancer cells (IC50s = 0.57 and 6.5 μg/ml, respectively) but not HeLa, KB, KBv200, or Hep-2 cells (IC50s = >100 μg/ml). |1. Naveen, B., Ommi, N.B.,...

化合物

SP-Chymostatin B
Cat.No: T26202
Synonym: alpha-Mapi
Target:
SP-B peptide
Cat.No: T80296
Synonym:
Target:
SP-146
Cat.No: T8685
Synonym:
Target: Aurora Kinase
SP-96
Cat.No: T41256
Synonym:
Target: Aurora Kinase
COR659
Cat.No: T36520
Synonym:
Target: Cannabinoid Receptor, GABA Receptor
Lokysterolamine B
Cat.No: T32848
Synonym: N-Acetyl-4beta-hydroxy-epi-plakinamine A
Target:
Dactylocycline B
Cat.No: T23957
Synonym:
Target:
Cinerubin B
Cat.No: T40457
Synonym:
Target:
Chrysomycin B
Cat.No: T38302
Synonym:
Target:
Sp-8-CPT-cAMPS
Cat.No: T38694
Synonym:
Target:
Anguinomycin A
Cat.No: T37542
Synonym:
Target:
Dalfopristin (mesylate) (112362-50-2 free base)
Cat.No: T22707
Synonym: Dalfopristin (mesylate)
Target: Others
Amycolatopsin B
Cat.No: T37540
Synonym:
Target:
Remisporine B
Cat.No: T37288
Synonym:
Target:
IKD-8344
Cat.No: T35742
Synonym:
Target:
Heliquinomycin
Cat.No: T36748
Synonym:
Target:
Carbazomycin A
Cat.No: T37536
Synonym:
Target:
(-)-Mycousnine
Cat.No: T37553
Synonym:
Target:
Benastatin A
Cat.No: T35978
Synonym:
Target:
Penicinoline
Cat.No: T35909
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
TN3853 Dihydromicromelin B

Others Others
Dihydromicromelin B is a natural product from Micromelum sp.
TN5376 Axinysone B

(-)-Axinysone B
Axinysone B is a natiral product from the metabolites of the mushroom Anthracophyllum sp. BCC18695.
T75624 Sadopeptins B

Sadopeptins B 是一种天然产物，可以从 Streptomycessp 中分离出来。Sadopeptins B 是一种有效的蛋白酶体抑制剂。
T38019 Nybomycin

Nybomycin is a fungal metabolite originally isolated from Streptomyces sp. A717 and has antibacterial activity. It is active against B. subtilis, B. cereus, B. mycoides, M. smegmatis, and K. pneumoniae (MICs = 0.025, 2, 0.8, 0.2, and 0.003 μg/ml, respectively). Nybomycin is also active against M. tuberculosis and M. bovis (MICs = 4.5 and 1 μg/ml, respectively).
T38349 Talaromycesone A

Talaromycesone A is a fungal metabolite originally isolated fromTalaromyces.1It is active againstS. epidermidisand methicillin-resistantS. aureus(MRSA) bacteria (IC50s = 3.70 and 5.48 μM, respectively). Talaromycesone A inhibits acetylcholinesterase (AChE) in a cell-free assay (IC50= 7.49 μM for the human enzyme). 1.Wu, B., Ohlendorf, B., Oesker, V., et al.Acetylcholinesterase inhibitors from a marine fungus Talaromyces sp. strain LF458Mar. Biotechnol. (NY)17(1)110-119(2015)
T35761 Carviolin

Carviolin is an anthraquinone fungal metabolite that has been found inZ. longicaudatawith immunosuppressive and antitrypanosomal activities.1,2It inhibits LPS- or concanavalin A-induced proliferation of mouse splenocytes (IC50s = 4 and 4.5 μg/ml, respectively).1Carviolin is active againstT. b. brucei(MIC = 41.66 μM).2 1.Fujimoto, H., Nakamura, E., Okuyama, E., et al.Six immunosuppressive features from an ascomycete, Zopfiella longicaudata, found in a screening study monitored by immunomodulatory...
T37451 Stachybotrysin B

Stachybotrysin B is a fungal metabolite originally isolated from S. chartarum and has antiviral and anticancer activities.1,2 It has antiviral activity against HIV in SupT1 cells (IC50 = 19.2 μM).1 Stachybotrysin B is cytotoxic to K562, HeLa, and HL-60 cells (IC50s = 21.72, 39.63, and 18.5 μM, respectively).2 |1. Zhao, J., Feng, J., Tan, Z., et al. Stachybotrysins A-G, phenylspirodrimane derivatives from the fungus Stachybotrys chartarum. J. Nat. Prod. 80(6), 1819-1826 (2017).|2. Ma, X.-h., Zhen...
T36329 Terpendole I

Terpendole I is a fungal metabolite that has been found in A. yamanashiensis.1 It is a weak inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 145 μM) and is active against the bacteria B. cereus and B. subtilis (MICs = 100 μg/ml for both) but not S. aureus, P. aeruginosa, or K. pneumoniae (MICs = >200 μg/ml for all) or the fungus C. albicans (MIC = 200 μg/ml).1,2 It is cytotoxic to HeLa cells with an IC50 value of 52.6 μM.3 |1. Tomoda, H., Tabata, N., Yang, D.-J., et al. Ter...

天然产物

Dihydromicromelin B
Cat.No: TN3853
Synonym:
Target: Others
Axinysone B
Cat.No: TN5376
Synonym: (-)-Axinysone B
Target:
Sadopeptins B
Cat.No: T75624
Synonym:
Target:
Nybomycin
Cat.No: T38019
Synonym:
Target:
Talaromycesone A
Cat.No: T38349
Synonym:
Target:
Carviolin
Cat.No: T35761
Synonym:
Target:
Stachybotrysin B
Cat.No: T37451
Synonym:
Target:
Terpendole I
Cat.No: T36329
Synonym:
Target:
Species：
Human (6)
Mouse (1)
Expression System：
HEK293 Cells (5)
CHO Cells (1)
P. pastoris (Yeast) (1)
Tag：
C-His-Avi (3)
C-His (2)
C-hFc (1)
Tag Free (1)
Cat. No. Product Name Species Expression System
TMPY-06810 SFTPB Protein, Human, Recombinant (His)

SFTP3,SMDP1,PSP-B,SFTB3,SP

Human CHO Cells
Pulmonary surfactant-associated protein B, also known as SFTPB and SP-B, contains one saposin A-type domain and three saposin B-type domains. SP-B is produced primarily by alveolar type II cells (AEC2) but also by nonciliated respiratory epithelial cells lining distal portions of the respiratory tract. Its secretion promotes alveolar homeostasis, stabilizing lipid layers and lowering surface tension at the air-liquid interface in the peripheral air spaces. Alveolar SP-B influences surfactant for...
TMPY-00552 PSG1 Protein, Human, Recombinant (His)

PS-β-G-1,PSBG-1,PS-beta-G-1,CD66f,pregnanc...

 Human HEK293 Cells
PSG1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44.9 kDa and the accession number is P11464-1.
TMPY-00551 PSG1 Protein, Human, Recombinant (hFc)

PSGIIA,PS-β-C/D,FL-NCA-1/2,PSBG1,PSG95,PS-b

Human HEK293 Cells
PSG1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 70.2 kDa and the accession number is P11464-1.
TMPH-01979 SFTPB Protein, Human, Recombinant

Human P. pastoris (Yeast)
Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter. SFTPB Protein, Human, Recombinant is expressed in yeast. The predicted molecular weight is 8.7 kDa and the accession number is P07988.
TMPK-01413 H-2K (b) &B2M&OVA (SIINFEKL) Monomer Protein, Mouse, MHC (His & Avi)

H-2K,OVA,MHC,H2-K1

 Mouse HEK293 Cells
Ovalbumin (OVA) has been historically a popular source of such antigens, since OVA can induce both humoral and cellular immune responses based on well-characterised peptide epitopes. The OVA257-264 octapeptide was one of the frst OVA epitopes to be characterised, it has an amino acid sequence SIINFEKL, which is recognised by cytotoxic T lymphocytes. SIINFEKL forms fbrillar assemblies similar to other peptide hydrogels. Te immunoactive properties of this peptide can therefore be related to its se...
TMPK-01412 HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi)

SARS-CoV-2 epitope,MHC

 Human HEK293 Cells
HLA-B*15:01 is strongly associated with asymptomatic infection with SARS-CoV-2 and is likely to be involved in the mechanism underlying early viral clearance. T cells from pre-pandemic individuals carrying HLA-B*15:01 were reactive to the immunodominant SARS-CoV-2 S-derived peptide NQKLIANQF, and 100% of the reactive cells displayed memory phenotype.
TMPK-01416 HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi), Biotinylated

MHC,SARS-CoV-2 epitope

 Human HEK293 Cells
HLA-B*15:01 is strongly associated with asymptomatic infection with SARS-CoV-2 and is likely to be involved in the mechanism underlying early viral clearance. T cells from pre-pandemic individuals carrying HLA-B*15:01 were reactive to the immunodominant SARS-CoV-2 S-derived peptide NQKLIANQF, and 100% of the reactive cells displayed memory phenotype.

重组蛋白

SFTPB Protein, Human, Recombinant (His)
Cat.No: TMPY-06810
Species: Human
Expression System: CHO Cells
PSG1 Protein, Human, Recombinant (His)
Cat.No: TMPY-00552
Species: Human
Expression System: HEK293 Cells
PSG1 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-00551
Species: Human
Expression System: HEK293 Cells
SFTPB Protein, Human, Recombinant
Cat.No: TMPH-01979
Species: Human
Expression System: P. pastoris (Yeast)
H-2K (b) &B2M&OVA (SIINFEKL) Monomer Protein, Mouse, MHC (His & Avi)
Cat.No: TMPK-01413
Species: Mouse
Expression System: HEK293 Cells
HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi)
Cat.No: TMPK-01412
Species: Human
Expression System: HEK293 Cells
HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi), Biotinylated
Cat.No: TMPK-01416
Species: Human
Expression System: HEK293 Cells
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上海市静安区江场三路238号8楼