Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8505 |
SC-236
4-(5-(4-氯苯基)-3-(三氟甲基)-1H-,Sc 236 |
Apoptosis; COX; PPAR | Apoptosis; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Neuroscience |
SC-236 (Sc 236) 是一种具有口服活性的COX-2特异性抑制剂和PPARγ激动剂。它可通过 c-Jun 氨基端抑制激活蛋白-1活性,在小鼠模型中通过抑制 ERK 的磷酸化发挥抗炎作用。 | |||
T12115 |
MSC2360844
|
PI3K | PI3K/Akt/mTOR signaling |
MSC2360844 是一种选择性的、具有口服活性的PI3Kδ抑制剂,其 IC50=145 nM。它对一组 278 种其他激酶显示出高度选择性。 | |||
T39094 | MSC2360844 hemifumarate | ||
MSC2360844 hemifumarate is a highly potent and orally active compound that acts as a selective inhibitor of PI3Kδ, with an IC50 value of 145 nM. This compound exhibits exceptional selectivity against a comprehensive panel of 278 additional kinases. |