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2

抑制剂 & 化合物

5

天然产物

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Cat. No. Product Name Target Signaling Pathways
T10260 Aglafoline

Rocaglamide U,Aglafolin,(-)-Methyl rocaglate

Others Others
Aglafoline inhibits in a concentration-dependent manner the aggregation and ATP release reaction induced in washed rabbit platelets by PAF (platelet-activating factor). The IC50 values of Aglafoline on PAF (3.6 nM)-induced platelet aggregation were about 50 μM.
T36750 Didesmethylrocaglamide

Didesmethylrocaglamide, a Rocaglamide derivative, is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor that exhibits strong growth-inhibitory effects, with an IC50 of 5 nM. It hinders several growth-promoting signaling pathways and triggers apoptosis in tumor cells, demonstrating antitumor activity[1].

化合物

Aglafoline
Cat.No: T10260
Synonym: Rocaglamide U,Aglafolin,(-)-Methyl rocaglate
Target: Others
Didesmethylrocaglamide
Cat.No: T36750
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
TQ0131 Rocaglamide

Rocaglamide A,楝酰胺,Roc-A

HSP; NF-κB; PERK Apoptosis; Cytoskeletal Signaling; Metabolism; NF-κB
Rocaglamide (Roc-A) 是从米仔兰中分离出来的一种天然产物,具有抗癌特性,可用于咳嗽,受伤,哮喘和炎症性皮肤病。它是一种有效的选择性热休克因子 1 活化抑制剂,IC50约为 50 nM。它是 T 细胞中 NF-κB 活化的有效抑制剂,还抑制翻译起始因子eIF4A 的功能。
TN2952 3'-Hydroxyrocaglamide

Others Others
3'-Hydroxyrocaglamide has insecticidal activity.
TN3838 Desmethylrocaglamide

Others Others
Desmethylrocaglamide is a novel inducer of cellular differentiation using HL-60 promyelocytic cells, it may be a drug for the prevention and therapy of cancer. It also has insecticidal activity.
TN2962 3'-Methoxyrocaglamide

Others Others
C-3'-Methoxyrocaglamide has insecticidal activity.
T78475 Rocagloic acid

Rocagloic acid,一种racaglamide衍生物,来源于Aglaia elliptifolia果实,具备显著的细胞毒性。

天然产物

Rocaglamide
Cat.No: TQ0131
Synonym: Rocaglamide A,楝酰胺,Roc-A
Target: HSP, NF-κB, PERK
3'-Hydroxyrocaglamide
Cat.No: TN2952
Synonym:
Target: Others
Desmethylrocaglamide
Cat.No: TN3838
Synonym:
Target: Others
3'-Methoxyrocaglamide
Cat.No: TN2962
Synonym:
Target: Others
Rocagloic acid
Cat.No: T78475
Synonym:
Target:
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