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Cat. No. | Product Name | Target | Signaling Pathways |
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T10260 |
Aglafoline
Rocaglamide U,Aglafolin,(-)-Methyl rocaglate |
Others | Others |
Aglafoline inhibits in a concentration-dependent manner the aggregation and ATP release reaction induced in washed rabbit platelets by PAF (platelet-activating factor). The IC50 values of Aglafoline on PAF (3.6 nM)-induced platelet aggregation were about 50 μM. | |||
T36750 |
Didesmethylrocaglamide
|
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Didesmethylrocaglamide, a Rocaglamide derivative, is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor that exhibits strong growth-inhibitory effects, with an IC50 of 5 nM. It hinders several growth-promoting signaling pathways and triggers apoptosis in tumor cells, demonstrating antitumor activity[1]. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TQ0131 |
Rocaglamide
Rocaglamide A,楝酰胺,Roc-A |
HSP; NF-κB; PERK | Apoptosis; Cytoskeletal Signaling; Metabolism; NF-κB |
Rocaglamide (Roc-A) 是从米仔兰中分离出来的一种天然产物,具有抗癌特性,可用于咳嗽,受伤,哮喘和炎症性皮肤病。它是一种有效的选择性热休克因子 1 活化抑制剂,IC50约为 50 nM。它是 T 细胞中 NF-κB 活化的有效抑制剂,还抑制翻译起始因子eIF4A 的功能。 | |||
TN2952 | 3'-Hydroxyrocaglamide | Others | Others |
3'-Hydroxyrocaglamide has insecticidal activity. | |||
TN3838 |
Desmethylrocaglamide
|
Others | Others |
Desmethylrocaglamide is a novel inducer of cellular differentiation using HL-60 promyelocytic cells, it may be a drug for the prevention and therapy of cancer. It also has insecticidal activity. | |||
TN2962 |
3'-Methoxyrocaglamide
|
Others | Others |
C-3'-Methoxyrocaglamide has insecticidal activity. | |||
T78475 |
Rocagloic acid
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Rocagloic acid,一种racaglamide衍生物,来源于Aglaia elliptifolia果实,具备显著的细胞毒性。 |