Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0349 |
Riluzole
PK 26124,RP-54274,利鲁唑 |
GABA Receptor; Sodium Channel; NMDAR | Membrane transporter/Ion channel; Neuroscience |
Riluzole (RP-54274) 是一种谷氨酸拮抗剂,用作抗惊厥药并延长肌萎缩侧索硬化症患者的生存期。它还抑制 GABA 摄取,IC50值为 43 μM。 | |||
T37608 |
Riluzole-13C,15N2
Riluzole-13C,15N2 |
||
Riluzole-13C,15N2 is intended for use as an internal standard for the quantification of riluzole by GC- or LC-MS. Riluzole is a benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic release of glutamate, indirectly antagonizing glutamate receptors, and inactivating neuronal voltage-gated Na+ channels (ED50 = 2.3 μM). Riluzole suppresses glutamate-induced seizures in rats at an ED50 value of 3.2 mg/kg and displays neuroprotective effects in hypoxic animals a... | |||
T41265 |
Riluzole hydrochloride
|
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Riluzole hydrochloride 是一种抗惊厥药物,属于依赖于使用的钠通道阻滞剂家族,也可以抑制 GABA 摄取,IC50值为 43 μM。 | |||
T35919 | N-hydroxy Riluzole | ||
N-hydroxy Riluzole is a metabolite of the antiglutamatergic agent riluzole .1It is formed from riluzole predominantly by the cytochrome P450 (CYP) isoform CYP1A2 in human hepatic microsomes. 1.Sanderink, G.J., Bournique, B., Stevens, J., et al.Involvement of human CYP1A isoenzymes in the metabolism and drug interactions of riluzole in vitroJ. Pharmacol. Exp. Ther.282(3)1465-1472(1997) | |||
T17174 |
Troriluzole
BHV-4157 |
Others | Others |
Troriluzole is an orally active glutamate modulator. Troriluzole reduces the synaptic glutamate level and increases synaptic glutamate absorption. | |||
T80626 |
VGSCs-IN-1
|
Sodium Channel | Membrane transporter/Ion channel |
VGSCs-IN-1 是一种有效的 VGSC 抑制剂,是一种 Riluzole 的 2-哌嗪类似物,在Nav1.4上展现出良好的阻断活性。VGSCs-IN-1可用于研究细胞兴奋性障碍。 |