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Cat. No. Product Name Target Signaling Pathways
T0349 Riluzole

PK 26124,RP-54274,利鲁唑

GABA Receptor; Sodium Channel; NMDAR Membrane transporter/Ion channel; Neuroscience
Riluzole (RP-54274) 是一种谷氨酸拮抗剂,用作抗惊厥药并延长肌萎缩侧索硬化症患者的生存期。它还抑制 GABA 摄取,IC50值为 43 μM。
T37608 Riluzole-13C,15N2

Riluzole-13C,15N2

Riluzole-13C,15N2 is intended for use as an internal standard for the quantification of riluzole by GC- or LC-MS. Riluzole is a benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic release of glutamate, indirectly antagonizing glutamate receptors, and inactivating neuronal voltage-gated Na+ channels (ED50 = 2.3 μM). Riluzole suppresses glutamate-induced seizures in rats at an ED50 value of 3.2 mg/kg and displays neuroprotective effects in hypoxic animals a...
T41265 Riluzole hydrochloride

Riluzole hydrochloride 是一种抗惊厥药物,属于依赖于使用的钠通道阻滞剂家族,也可以抑制 GABA 摄取,IC50值为 43 μM。
T35919 N-hydroxy Riluzole

N-hydroxy Riluzole is a metabolite of the antiglutamatergic agent riluzole .1It is formed from riluzole predominantly by the cytochrome P450 (CYP) isoform CYP1A2 in human hepatic microsomes. 1.Sanderink, G.J., Bournique, B., Stevens, J., et al.Involvement of human CYP1A isoenzymes in the metabolism and drug interactions of riluzole in vitroJ. Pharmacol. Exp. Ther.282(3)1465-1472(1997)
T17174 Troriluzole

BHV-4157

Others Others
Troriluzole is an orally active glutamate modulator. Troriluzole reduces the synaptic glutamate level and increases synaptic glutamate absorption.
T80626 VGSCs-IN-1

Sodium Channel Membrane transporter/Ion channel
VGSCs-IN-1 是一种有效的 VGSC 抑制剂,是一种 Riluzole 的 2-哌嗪类似物,在Nav1.4上展现出良好的阻断活性。VGSCs-IN-1可用于研究细胞兴奋性障碍。

化合物

Riluzole
Cat.No: T0349
Synonym: PK 26124,RP-54274,利鲁唑
Target: GABA Receptor, Sodium Channel, NMDAR
Riluzole-13C,15N2
Cat.No: T37608
Synonym: Riluzole-13C,15N2
Target:
Riluzole hydrochloride
Cat.No: T41265
Synonym:
Target:
N-hydroxy Riluzole
Cat.No: T35919
Synonym:
Target:
Troriluzole
Cat.No: T17174
Synonym: BHV-4157
Target: Others
VGSCs-IN-1
Cat.No: T80626
Synonym:
Target: Sodium Channel
TargetMol Loading
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