Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Riluzole hydrochloride 是一种抗惊厥药物,属于依赖于使用的钠通道阻滞剂家族,也可以抑制 GABA 摄取,IC50值为 43 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 128 | 5日内发货 | ||
5 mg | ¥ 185 | 5日内发货 | ||
10 mg | ¥ 255 | 5日内发货 |
Riluzole hydrochloride 的其他形式现货产品:
产品描述 | Riluzole hydrochloride, a use-dependent Na+ channel blocker with anticonvulsant properties, belongs to a category of drugs that also inhibit GABA uptake, exhibiting an inhibitory concentration 50 (IC50) of 43 μM. |
体外活性 | Riluzole hydrochloride is an anticonvulsant drug and belongs to the family of use-dependent Na + channel blocker which can also inhibit GABA uptake with an IC 50 of 43 μM. At 20 μM, Riluzole hydrochloride inhibits peak autaptic IPSCs only slightly but reliably prolongs IPSCs. It is also found that Riluzole hydrochloride causes a strong, concentration-dependent, readily reversible enhancement of responses to 2 μM GABA. At higher concentrations of Riluzole hydrochloride, especially 300 μM, GABA currents exhibit apparent desensitization during prolonged co-exposure to 2 μM GABA and Riluzole hydrochloride. The EC 50 of Riluzole hydrochloride potentiation of GABA responses is about 60 μM [1]. |
体内活性 | In normal na ve rats, systemic injection of Riluzole hydrochloride (8 mg/kg, i.p.; n=6 rats) reduces the duration of ultrasonic but not audible vocalizations evoked by noxious stimulation of the knee joint compare to vehicle tested in the same rats (P<0.05). Systemic application of Riluzole hydrochloride (8 mg/kg, i.p.; n=19 rats) decreases the vocalizations of arthritic rats compare to predrug and vehicle significantly (P<0.05 to 0.001). Riluzole hydrochloride administered into the CeA significantly decreases the duration of audible and ultrasonic vocalizations evoked by noxious stimulation of the knee compare to predrug values (n=8 rats; P<0.05 to 0.01) [2]. |
分子量 | 270.66 |
分子式 | C8H6ClF3N2OS |
CAS No. | 850608-87-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Riluzole hydrochloride 850608-87-6 Riluzole Hydrochloride Inhibitor inhibitor inhibit