34
9
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T61132 |
NLRP3-IN-11
|
NOD | Immunology/Inflammation; NF-κB |
NLRP3-IN-11 是一种NLRP3蛋白抑制剂,具有潜在的抗炎活性。NLRP3-IN-11 可用于研究 动脉粥样硬化、阿尔茨海默病和帕金森病类自身炎症性疾病炎症和退行性疾病。 | |||
T61392 |
NLRP3-IN-10
ZVN26391 |
NOD | Immunology/Inflammation; NF-κB |
NLRP3-IN-10 (ZVN26391) 是强效的 NLRP3 抑制剂,抑制 IL-1β 释放的 IC50 为 251.1 nM。NLRP3-IN-10 通过减弱 ASC 斑点形成来抑制 NLRP3炎症小体激活。 | |||
TP1936L1 |
RFRP3(human) acetate(311309-27-0 free base)
|
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
RFRP3(human) acetate(311309-27-0 free base) 是一种人类 GnIH 肽同源物,是一种有效的促性腺激素分泌抑制剂,可抑制 Ca2+ 动员。它是一种 NPFF1 受体激动剂,它抑制毛喉素诱导的 cAMP 产生,IC50 为 0.7 nM。 | |||
T3230 |
NLRP3-IN-2
5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide,4-[2-(5-氯-2-甲氧基苯甲酰氨基)乙基]苯磺酰胺,NLRP3 Inflammasome Inhibitor I |
NOD-like Receptor (NLR); NOD | Immunology/Inflammation; NF-κB |
NLRP3-IN-2 (5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide) 是一种能够合成格列本脲的中间物,对心肌细胞中NLRP3炎症小体的形成具有抑制作用,在小鼠心肌缺血/再灌注后限制梗死面积,且对代谢无影响。 | |||
T28178 |
NLRP3-IN-9
INF-4E,INF 4E,INF4E |
NOD | Immunology/Inflammation; NF-κB |
NLRP3-IN-9 (INF-4E) 是 NLRP3 ATPase 和 caspase-1 的抑制剂。 NLRP3-IN-9 通过不可逆地捕获硫醇亲核体发挥作用,以时间和浓度依赖性方式防止 ATP 和尼日利亚菌素触发的人 THP-1 细胞焦亡。 | |||
T60442 |
NLRP3/AIM2-IN-3
|
NOD; AIM2 | Immunology/Inflammation; NF-κB |
NLRP3/AIM2-IN-3 是一种独特的分子,能以物种特异性的方式抑制 NLRP3 和 AIM2 炎性体的激活。它对细胞裂解的 IC50 值为 0.077 ± 0.008 μ M。NLRP3/AIM2-IN-3是一种 NLRP3 和 AIM2 炎症体依赖性细胞裂解的强效抑制剂,对细胞裂解的 IC50 值为 0.077 ± 0.008 μ M。NLRP3/AIM2-IN-3 可抑制 LPS/nigericin 刺激的 THP-1 巨噬细胞的细胞裂解,其 IC50 值为 0.077 ± 0.008 μM。NLRP3/AIM2-IN-3 干扰了 NLRP3 或 AIM2 与桥接蛋白 ASC 的相互作用,抑制了 ASC 的寡聚。 | |||
TP1984L |
[D-Trp34]-Neuropeptide Y Acetate
[D-Trp34]-Neuropeptide Y Acetate (153549-84-9 Free base) |
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
[D-Trp34]-Neuropeptide Y Acetate 是有效的、选择性的神经肽 Y (NPY) Y5 受体激动剂,在 NPY Y1,Y2,Y4 和 y6 受体上的效力较低。[D-Trp34]-Neuropeptide Y Acetate 可以显著增加大鼠的食物摄入量。 | |||
T60404 |
NLRP3/AIM2-IN-2
|
AIM2 | Immunology/Inflammation |
NLRP3/AIM2-IN-2是一种新型强效抑制剂,对依赖于 NLRP3和 AIM2炎症体的热扩散具有不同物种特异性影响,IC50为0.2392 ± 0.0233 μ M。 | |||
T60756 | NLRP3 antagonist 1 | ||
NLRP3 antagonist 1 具有癌症疾病的研究潜力,是NLRP3的有效拮抗剂。NLRP3 参与机体对应激损伤和病原体感染的内在免疫,主要表达在巨噬细胞和中性粒细胞。 | |||
T78168 | NLRP3-IN-17 | NOD-like Receptor (NLR) | Immunology/Inflammation |
NLRP3-IN-17为一种高效、选择性且具有口服活性的NLRP3炎性体抑制剂,IC50为7 nM。该化合物在小鼠模型中显著抑制NLRP3依赖的IL-1β分泌,适用于慢性炎症疾病的研究。 | |||
T61826 | NLRP3-IN-4 | ||
NLRP3-IN-4 is a highly efficient and orally bioavailable inhibitor of NLRP3 inflammasome, which exhibits strong anti-inflammatory properties specifically targeted towards colitis. | |||
T78894 | NLRP3-IN-21 | NOD-like Receptor (NLR) | Immunology/Inflammation |
NLRP3-IN-21(compound L38)是一款NLRP3炎症体抑制剂,具抗炎特性。此化合物能够抑制gasdermin D裂解、防止ASC寡聚化,并阻止NLRP3炎症小体的组装,从而遏制NLRP3炎症小体的激活及焦亡过程。 | |||
T73015 |
NLRP3-IN-16
|
NOD-like Receptor (NLR) | Immunology/Inflammation |
NLRP3-IN-16为高效、选择性NLRP3炎症小体抑制剂。其抑制IL-1β释放的IC50为0.131 μM,适用于炎症相关研究。 | |||
T79695 |
NLRP3-IN-19
NLRP3-IN-19 |
NOD-like Receptor (NLR) | Immunology/Inflammation |
NLRP3-IN-19(JT001)是一种高效、特异性且具有口服活性的NLRP3抑制剂,能够阻断NLRP3炎症小体的组装,抑制细胞因子释放,并预防细胞焦亡。该化合物适用于非酒精性脂肪性肝炎和肝纤维化研究。 | |||
T73014 | NLRP3-IN-15 | ||
NLRP3-IN-15 是一种有效的、选择性的 NLRP3炎症小体抑制剂 (KD: 5.87 μM)。NLRP3-IN-15 抑制 IL-1β 释放,IC50为 0.131 μM。NLRP3-IN-15可用于炎症研究。 | |||
T76350 |
[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH
|
||
[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH 是一种黄体激素释放激素 (LHRH) 类似物,可作为 GnRH 受体拮抗剂。 | |||
TP1984 |
[D-Trp34]-Neuropeptide Y
|
||
Potent neuropeptide Y (NPY) Y5 receptor agonist (pEC50 values are 7.82, 6.28, 6.44 and > 6 at rat Y5, Y4, Y1 and Y2 receptors respectively) that displays > 26-fold, > 1000-fold and > 1000-fold selectivity over Y1, Y2 and Y4 receptors respectively. Induces | |||
T81668 |
NLRP3 agonist 1
|
NOD-like Receptor (NLR) | Immunology/Inflammation |
NLRP3 agonist1 (compound 23)为高效口服活性NLRP3激动剂。该化合物能够激活Caspase-1酶,进而将pro-IL-1β与pro-IL-18等促炎细胞因子裂解为成熟型态。 | |||
T73013 |
NLRP3-IN-14
|
||
NLRP3-IN-14 是一种有效的、选择性的 NLRP3炎症小体抑制剂 (KD: 5.87 μM)。NLRP3-IN-14 抑制 IL-1β 释放,IC50为 0.131 μM。NLRP3-IN-14可用于炎症研究。 | |||
T73018 |
NLRP3-IN-13
|
||
NLRP3-IN-13 是一种有效的选择性NLRP3抑制剂 (IC50: 2.1 μM)。NLRP3-IN-13 抑制NLRP3和 NLRC4 炎性体,并抑制NLRP3介导的 IL-1β 产生。NLRP3-IN-13 还抑制NLRP3ATPase 活性。NLRP3-IN-13可用于神经炎症疾病的研究。 | |||
T62809 | NLRP3-IN-7 | ||
NLRP3-IN-7 (Compound 36) 是一种 NLRP3炎性体的选择性抑制剂,能够 NLRP3 炎性体的组装。 | |||
T81665 | NLRP3-IN-23 | NOD-like Receptor (NLR) | Immunology/Inflammation |
NLRP3-IN-23 (Compound 15C) 是 NLRP3 炎症体激发的抑制剂,特别针对血红素介导机制。该化合物在 0.1μM 浓度时能显著抑制血红素诱导的 NLRP3 炎症体激活。 | |||
T81667 | NLRP3 agonist 2 | NOD-like Receptor (NLR) | Immunology/Inflammation |
NLRP3 agonist2(compound 22)为口服有效的NLRP3激动剂,能在THP1细胞内激活Caspase-1。 | |||
T75911 |
[D-Trp34]-Neuropeptide Y TFA
|
||
[D-Trp34]-Neuropeptide Y TFA,一种高效且选择性的神经肽Y (NPY) Y5受体激动剂,其在NPY Y1、Y2、Y4及Y6受体上的活性显著低于Y5受体。该化合物能显著提高大鼠的食物摄入量。 | |||
T78180 |
NLRP3-IN-18
|
NOD-like Receptor (NLR) | Immunology/Inflammation |
NLRP3-IN-18(化合物13)是一种高效NLRP3抑制剂,其半抑制浓度(IC50)为1.0 µM或更低[1]。 | |||
T39607 |
NLRP3 modulators 1
NLRP3 modulators 1 |
||
NLRP3 modulators 1 (WO2017184746A1, compound 107) is a potent modulator of NLRP3, capable of agonizing or partially agonizing the activity of NLRP3. This compound proves valuable in investigating conditions, diseases, or disorders where a reduction in LRP3 activity plays a role in the pathology. | |||
T73034 |
NLRP3-IN-12
|
||
NLRP3-IN-12 是一种特异性的 NLRP3炎症小体抑制剂。NLRP3-IN-12 通过靶向 NLRP3蛋白抑制 IL-1β 的释放,IC50值为 0.45 μM。NLRP3-IN-12 可用于研究炎症性肠病。 | |||
T39552 |
NLRP3-IN-5
NLRP3-IN-5 |
||
NLRP3-IN-5, a compound disclosed in WO2016131098, is an inhibitor of NLRP3 inflammasome. It consists of the chemical structure N-((4-chloro-2,6-dimethylphenyl)carbamoyl)-4-(2-hydroxypropan-2-l)furan-2-sulfonamide. | |||
T62808 | NLRP3-IN-6 | ||
NLRP3-IN-6 (Compound 34) 是一种 NLRP3 炎性体的选择性抑制剂。 | |||
T81666 | NLRP3-IN-22 | NOD-like Receptor (NLR) | Immunology/Inflammation |
NLRP3-IN-22 (Compound II-4) 作为NLRP3抑制剂,展现出在10 μM浓度下67%的抑制效果。 | |||
T82965 |
ARTD3/PARP3-IN-1
|
||
ARTD3/PARP3-IN-1为ARTD3/PARP3的非选择性抑制剂,作用于白喉毒素样ADP-核糖基转移酶3(ARTD3)。 | |||
T60563 | NLRP3/AIM2-IN-1 | ||
NLRP3/AIM2-IN-1是热脓毒症的抑制剂(IC50 = 3.136 ± 0.7667 μM),显示出适度的反热光活性。 | |||
T79733 | NLRP3-IN-20 | NOD-like Receptor (NLR) | Immunology/Inflammation |
NLRP3-IN-20(compound 11)是一款口服活性的NLRP3炎症小体抑制剂,其抑制IL-1β分泌的IC50值为25 nM。该化合物展现出卓越的药代动力学性质,并在非酒精性脂肪性肝炎、致命性感染性休克以及结肠炎模型中证明了其显著疗效。 | |||
T62221 | NLRP3-IN-8 | ||
NLRP3-IN-8 (compound 27) 是具有口服活性的、与 NLRP3直接结合的 NLRP3炎性体抑制剂,对 IL-1β 的 IC50值为1.23 μM. NLRP3-IN-8 对肝微粒体具有良好的代谢稳定性 (t1/2= 138.63 min),几乎没有毒性 (against L02: IC50> 100 μM) 。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01929 |
ECE1 Protein, Human, Recombinant (His)
RP3-329E20.1,endothelin convertin... |
Human | HEK293 |
Endothelin-converting enzyme 1, also known as ECE-1, is a single-pass type II membrane protein which belongs to thepeptidase M13 family. ECE-1 converts big endothelin-1 to endothelin-1. ECE-1 is a membrane metalloprotease that generates endothelin from its direct precursor big endothelin. Four isoforms of ECE-1 are produced from a single gene through the use of alternate promoters. These isoforms share the same extracellular catalytic domain and contain unique cytosolic tails, which resul... | |||
TMPY-04567 |
SRPK1 Protein, Human, Recombinant (His & GST)
SRSF protein kinase 1,SFRSK1,RP3-422H11.1 |
Human | Baculovirus-Insect Cells |
Serine / threonine-protein kinase SRPK1, also known as SFRS protein kinase 1, Serine/arginine-rich protein-specific kinase 1, SR-protein-specific kinase 1 and SRPK1, is a cytoplasm and nucleus protein that belongs to the protein kinase superfamily and CMGC Ser/Thr protein kinase family. Isoform 2 of SRPK1 is predominantly expressed in the testis but is also present at lower levels in heart, ovary, small intestine, liver, kidney, pancreas and skeletal muscle. Isoform 1 of SRPK1 is only seen in th... | |||
TMPY-03865 |
EB3 Protein, Human, Recombinant (His)
microtubule-associated protein, RP/EB family, membe... |
Human | E. coli |
MAPRE3 (Microtubule Associated Protein RP/EB Family Member 3, also known as EB3) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. MAPRE3 is a member of the RP/EB family. It localizes to the cytoplasmic microtubule network and binds APCL. MAPRE3 regulates the dynamics of the microtubule cytoskeleton and promotes microtubule growth. It may be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. MAPRE3 may also play a role i... | |||
TMPY-02421 |
PARP3 Protein, Human, Recombinant (His & GST)
ARTD3,IRT1,ADPRTL2,ADPRTL3,poly (ADP-ribos... |
Human | Baculovirus-Insect Cells |
Poly(ADP-ribose) polymerase 3 (PARP3) is an important member of the PARP family and shares high structural similarities with both PARP1 and PARP2. Poly(ADP-ribose) polymerase 3 (PARP3), a critical player in cellular response to DNA double-strand breaks (DSBs), plays an essential role in the maintenance of genome integrity. The ADP ribosyl transferase [poly(ADP-ribose) polymerase] ARTD3(PARP3) is a newly characterized member of the ARTD(PARP) family that catalyzes the reaction of ADP ribosylation... | |||
TMPH-01739 |
NLRP3 Protein, Human, Recombinant (His)
|
Human | E. coli |
As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP3 inflammasome is also requi... | |||
TMPJ-01408 |
HDGFRP3 Protein, Human, Recombinant (His)
HDGF2,HRP-3,HDGF-2,Hepatoma-Derived Growth... |
Human | Human Cells |
Hepatoma-Derived Growth Factor-Related Protein 3 (HDGFRP3) belongs to the HDGF family. HDGFRP3 can be found in testis, heart, spinal cord and brain. HDGFRP3 localizes to the nucleus and contains one PWWP domain. HDGFRP3 enhances DNA synthesis and may have a role in cell proliferation. | |||
TMPH-01176 |
CSRP3 Protein, Human, Recombinant (His & SUMO)
CLP,CRP,Muscle LIM protein,CSRP3,... |
Human | E. coli |
CSRP3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPH-02796 |
NLRP3 Protein, Mouse, Recombinant (His & SUMO)
|
Mouse | E. coli |
NLRP3 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPY-00358 |
Arp3/ACTR3 Protein, Human, Recombinant (His & GST)
ARP3,ARP3 actin-related ... |
Human | Baculovirus-Insect Cells |
Arp3/ACTR3 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus-Insect Cells with His and GST tag. The predicted molecular weight is 75.1 kDa. Accession number: A0A024RAI1 |