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Cat. No. | Product Name | Target | Signaling Pathways |
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T8647 |
BCH001
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
BCH001 是喹啉衍生物,是一种选择性PAPD5抑制剂。它可以恢复先天性角化病诱导的多能干细胞中的端粒酶活性和端粒长度。它对聚 (A)-特异性核糖核酸酶或几种其他多核苷酸聚合酶均无抑制作用。它可用于调控衰老。 | |||
T5539 |
GS-443902
瑞德西韦代谢物 |
Nucleoside Antimetabolite/Analog; HCV Protease; SARS-CoV; DNA/RNA Synthesis; RSV; Drug Metabolite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; Proteases/Proteasome |
Remdesivir triphosphate 是一种有效的病毒 RNA 依赖的 RNA 聚合酶抑制剂,对RSVRdRp 和 HCVRdRp 的IC50分别为 1.1 µM 和 5 µM。它是 Remdesivir 的活性三磷酸代谢物。 | |||
T9618 |
HeE1-2Tyr
|
SARS-CoV | Microbiology/Virology |
HeE1-2Tyr 是 一种pyridobenzothiazole,抑制黄病毒 RNA 依赖性 RNA 聚合酶。HeE1-2Tyr 在体外对Dengue, West Nile 和 SARS-CoV-2 RdRps 有显著的抑制活性(IC50为 27.6 µM) 。 | |||
T16945 |
Streptolydigin
Portamycin |
Antibacterial | Microbiology/Virology |
Streptolydigin inhibits RNA synthesis by binding to RNA polymerase and does not inhibit eukaryotic RNA polymerases. Streptolydigin is a 3-acetyltetramic acid antibiotic and a potent bacterial RNA polymerase inhibitor (Ki: 18 μM and a Kd: 15 μM). | |||
T35657 |
3'-Deoxyuridine-5'-triphosphate
|
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3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into RNA with a Ki value of 2.0 μM[1]. 3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is synthesized starting from cordycepin in good yield. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into RNA by the RNA polymerases. 3'-Deoxyuridine-5'-tri... | |||
T40359 |
Thio-ITP
6-Thio-ITP,Thio-ITP,6-Mercaptopurine-riboside-5'-triphosphate,6-Thioinosine 5′-triphosphate |
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Thio-ITP, also known as 6-Thioinosine 5'-triphosphate, is a competitive inhibitor of RNA polymerase activity. It exhibits a strong apparent affinity towards the polymerases, with Ki values of 40.9 μM for RNA polymerase I and 38.0 μM for RNA polymerase II. | |||
T35658 | 3'-Deoxyuridine-5'-triphosphate trisodium | ||
3'-Deoxyuridine-5'-triphosphate trisodium (3'-dUTP trisodium) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate trisodium strongly and competitively inhibits the incorporations of UTP into RNA with a Ki value of 2.0 μM[1]. 3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is synthesized starting from cordycepin in good yield. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into RNA by the RNA polym... | |||
T38761 |
GS-443902 trisodium
GS-441524triphosphatetrisodium,Remdesivirmetabolitetrisodium,瑞德西韦代谢物三钠盐 |
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GS-443902 trisodium (GS-441524 triphosphate trisodium) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC 50 s of 1.1 μM, 5 μM for RSV RdRp and HCV RdRp, respectively. GS-443902 trisodium is the active triphosphate metabolite of Remdesivir (GS-5734). | |||
T80760 |
XSJ2-46
|
Influenza Virus | Microbiology/Virology |
XSJ2-46,一种5'-氨基NI类似物,表现为有效的抗病毒药物,尤其针对Zika病毒。它通过抑制RNA依赖性RNA聚合酶(RdRp),展示出其活性,具有8.78 μM的IC50值。 | |||
T38297 |
Ribavirin-13C5
Ribavirin-13C5 |
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Ribavirin-13C5is intended for use as an internal standard for the quantification of ribavirin by GC- or LC-MS. Ribavirin is an antiviral guanosine nucleoside analog.1,2Upon entry into cells, ribavirin is metabolized to an active triphosphate form that induces viral RNA chain termination and inhibits viral polymerases. It reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 μg/ml).3Ribavirin also reduces replication of severe acute respiratory syndrome coro... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T5288 |
Cytidine-5'-triphosphate disodium
胞苷 5'-三磷酸二钠盐,CTP,Cytidine 5'-triphosphate (disodium salt) |
Others; Endogenous Metabolite | Metabolism; Others |
Cytidine-5'-triphosphate disodium (CTP) 是内源性代谢产物的一种。 | |||
T7004 |
Tubercidin
结核菌素,杀结核菌素,Sparsomycin A,7-Deazaadenosine |
Influenza Virus; DNA/RNA Synthesis; Antibacterial; Antibiotic | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Tubercidin (Sparsomycin A) 是从Streptomyces tubercidicus 得到的抗生素,抑制粪链球菌生长的IC50值为 0.02 μM。它是腺苷磷酸化酶的弱抑制剂,并干扰腺苷和 AMP 的磷酸化。它有抗病毒作用。 | |||
T4010 |
Juglone
5-羟基对萘醌,5-Hydroxy-1,4-naphthoquinone,胡桃酮,Regianin |
DNA/RNA Synthesis; Antibacterial | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Juglone (Regianin) 是一种从黑胡桃Juglans regia 中发现的黄色染料,有抗菌作用。 |