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Search Results for " rage "

Targets Recommended: Beta Amyloid

14

抑制剂 & 化合物

10

天然产物

5

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
TP1935L1	RAGE antagonist peptide acetate	Beta Amyloid	Neuroscience
	RAGE antagonist peptide acetate 是一种高级的糖基化终产物 (RAGE) 拮抗剂。它具有抗肿瘤和抗炎活性。它可防止 RAGE 与其几个重要的配体结合，包括 HMGB-1、S100P 和 S100A4。
TP1935	RAGE antagonist peptide
	Receptor for advanced glycation end products (RAGE) antagonist. Blocks S100P, S100A4 and HMGB-1 mediated RAGE activation in vitro and in vivo. Inhibits growth and metastasis of rat glioma tumors. Reduces cell growth and RAGE-mediated NF-κB activity in hum
T61721	RAGE 229
	RAGE 229, N-(4-(7-cyano-4-(morpholin-4ylmethyl) quinolin-2-yl)phenyl)acetamide 是一种小分子 ctRAGE-DIAPH1抑制剂，具有口服活性。RAGE 229 可通过抑制 ctRAGE 与 DIAPH1 的相互作用来抑制细胞内 RAGE 信号。
T72824	RAGE/SERT-IN-1
	RAGE/SERT-IN-1 是一种 RAGE 和 SERT 抑制剂，口服活性良好，IC50 分别为 8.26 μM 和 31.09 nM。它对 Aβ25-35 诱发的神经元损伤具有显著神经保护效果，并可缓解小鼠抑郁症状。RAGE/SERT-IN-1 适用于阿尔茨海默病与抑郁症并发症的研究。
T125142	Oleragenoside
	Oleragenoside 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125142，CAS号为 274677-98-4。
T124466	(Z)-23-Coumaroylhederagenin
	(Z)-23-Coumaroylhederagenin 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124466。
T35327	Carrageenan kappa-Carrageenan	Antiviral	Immunology/Inflammation
	Carrageenan (kappa-Carrageenan) 是一种从食用红海藻中提取的天然碳水化合物（多糖）。Carrageenan 具有抗凝活性、抗血栓形成活性、抗病毒活性、抗肿瘤活性和免疫调节活性。
T3259	FPS-ZM1	Beta Amyloid; advanced glycation end products	Neuroscience; Others
	FPS-ZM1 是一种高亲和力的 RAGE 特异性抑制剂，可阻断 Aβ 与 RAGE 的 V 结构域的结合。
T39115	ABR-238901	TLR	Immunology/Inflammation
	ABR-238901是一种可口服的、有作用的 S100A8/A9阻滞剂，对 S100A8/A9与其受体 RAGE(晚期糖基化终产物受体)和TLR4 (toll 样受体4)的相互作用具有抑制作用。ABR-238901具有作为治疗心肌梗死(MI)化合物的潜力。
T2507	Azeliragon TTP488,阿齐瑞格	Beta Amyloid; advanced glycation end products	Neuroscience; Others
	Azeliragon (TTP488) 是一种生物可利用的、可穿过血脑屏障 (BBB)的晚期糖基化终产物 (RAGE) 受体抑制剂，可缓解轻度阿尔茨海默病 (AD) 的发展。
T14390	Azelaprag AMG 986	Apelin receptor	GPCR/G Protein
	Azelaprag (AMG 986) 是一种有效的小分子 apelin 受体激动剂。Azelaprag 可用于治疗神经系统疾病、心血管疾病。
T24598	BrBzGCp2 p BrBzGSH(Cp)2,BBGC,pBrBzGSH(Cp)2,p-BrBzGSH(Cp)2,BBGD
	p-BrBzGSH(Cp)2 is a glyoxylase 1 inhibitor. In orthotopic mouse models, it acts by increasing DNA-AGEs, stimulating RAGE expression, and inhibiting brain tumor growth.
T2507L2	Azeliragon HCl TTP488 HCl,Azeliragon hydrochloride,TTP 488,Azeliragon dihydrochloride,TTP-488
	Azeliragon is a potent and orally active inhibitor of RAGE (receptor for advanced glycation endproducts), a pattern recognition receptor, which affects the movement of amyloid, an Alzheimer's-associated protein, into the brain.
T35890	Pentosidine
	Advanced glycation end products (AGEs) are compounds formed by non-enzymatic chemical reactions following the bonding of sugars to proteins or lipids during diabetes, uremia, aging, rheumatic arthritis, and other conditions. A receptor for the AGEs (RAGE) binds certain members of this class to initiate cell signaling.[1][2] Pentosidine is a well-characterized natural AGE that is often used as a biomarker for the production of all AGEs. While pentosidine can be measured in urine, the majority of ...

化合物

RAGE antagonist peptide acetate

Cat.No: TP1935L1

Target: Beta Amyloid

RAGE antagonist peptide

Cat.No: TP1935

Cat.No: T61721

RAGE/SERT-IN-1

Cat.No: T72824

Cat.No: T125142

(Z)-23-Coumaroylhederagenin

Cat.No: T124466

Cat.No: T35327

Synonym: kappa-Carrageenan

Target: Antiviral

Cat.No: T3259

Target: Beta Amyloid, advanced glycation end products

Cat.No: T39115

Target: TLR

Cat.No: T2507

Synonym: TTP488,阿齐瑞格

Target: Beta Amyloid, advanced glycation end products

Cat.No: T14390

Synonym: AMG 986

Target: Apelin receptor

Cat.No: T24598

Synonym: p BrBzGSH(Cp)2,BBGC,pBrBzGSH(Cp)2,p-BrBzGSH(Cp)2,BBGD

Cat.No: T2507L2

Synonym: TTP488 HCl,Azeliragon hydrochloride,TTP 488,Azeliragon dihydrochloride,TTP-488

Cat.No: T35890

Cat. No.	Product Name	Target	Signaling Pathways
T3039	Hederagenin Hederagenic acid,常春藤苷元,Astrantiagenin E,Caulosapogenin,常春藤皂苷元,Hederagenol	Others	Others
	Hederagenin (Hederagenol) 是一种三萜皂苷，可以抑制细胞中由于LPS 刺激引起的 iNOS、COX-2和 NF-κB 的表达。
TN7020	Astragenol	Others	Others
	Astragenol 是合成黄芪醇衍生物的中间体。它的衍生物具有抗炎作用，可用于前列腺癌的研究。
T3S0208	Hederagenin 28-O-beta-D-glucopyranosyl ester Hederagenin-28-beta-D-glucopyranoside,常春苷元-28-BETA-D-吡喃葡萄糖苷,常春藤皂苷元28-O-beta-D-吡喃葡萄糖酯	Others	Others
	Hederagenin-28-beta-D-glucopyranoside 是一种分离自 Ilex cornuta 中的三萜皂苷，能够保护H2O2诱导的心肌细胞免于损伤。
T5575	Cycloastragenol 环黄芪醇,Cyclogalegenol,Astramembrangenin	Epigenetic Reader Domain; Telomerase	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Cycloastragenol (Astramembrangenin) 是一种三萜皂苷类化合物，是黄芪主要活性成分的水解产物，具有抗氧化、抗炎、抗衰老、抗凋亡和心血管保护作用。它是端粒酶激活剂，可以延长端粒，还能缓解与年龄相关的骨丢失，改善骨微结构和生物力学特性。
T78497	λ-Carrageenan
	λ-Carrageenan是广泛应用于基础研究的海藻多糖，常用作促炎剂，并具有有效的抗肿瘤活性。
T38499	κ-Carrageenan
	κ-Carrageenan, a natural polymer found predominantly in red seaweeds, can serve as an effective drug carrier for delivering curcumin to cancer cells and inducing apoptosis. Additionally, κ-Carrageenan holds promise as a potential inflammatory agent, amplifying existing intestinal inflammation.
TN5996	1-Oxohederagenin 1-氧代常春藤皂苷元,3β,23-Dihydroxy-1-oxo-olean-12-en-28-oic acid
	1-Oxohederagenin 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5996，CAS号为 618390-67-3。
T83345	3-O-α-L-Rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl hederagenin28-O-β-D-xylopyranosyl-(1→6)-β-D-glucopyranosyl ester
	3-O-α-L-Rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl hederagenin 28-O-β-D-xylopyranosyl-(1→6)-β-D-glucopyranosyl ester 是一种皂苷化合物，具备抗肿瘤与抗炎特性。
T5716	4'-Methoxyresveratrol 白藜芦醇-4'-甲醚,4'-O-Methylresveratrol	advanced glycation end products	Others
	4'-Methoxyresveratrol (4'-O-Methylresveratrol) 是一种多酚类化合物，来源于双翅目植物中，具有抗雄激素、抗真菌和抗炎症作用。它能抑制 RAGE- 介导的 MAPK/NF-κB 信号通路，并激活 NLRP3 炎性体，从而缓解 AGE- 诱导的炎症。
T4786	D-Ribose(mixture of isomers) D-Ribose,D-(-)-Ribose,D-(-)-核糖	Others; Endogenous Metabolite	Metabolism; Others
	D-Ribose(mixture of isomers) (D-(-)-Ribose) 是 ATP 的糖部分，可作为能量增强剂，被广泛用作慢性疲劳综合症和心肌能量代谢的代谢疗法补充剂。它在蛋白质糖化中具有特性，能够 RAGE 依赖的方式诱导 NF-Κb 炎症。

天然产物

Cat.No: T3039

Synonym: Hederagenic acid,常春藤苷元,Astrantiagenin E,Caulosapogenin,常春藤皂苷元,Hederagenol

Target: Others

Cat.No: TN7020

Target: Others

Hederagenin 28-O-beta-D-glucopyranosyl ester

Cat.No: T3S0208

Synonym: Hederagenin-28-beta-D-glucopyranoside,常春苷元-28-BETA-D-吡喃葡萄糖苷,常春藤皂苷元28-O-beta-D-吡喃葡萄糖酯

Target: Others

Cycloastragenol

Cat.No: T5575

Synonym: 环黄芪醇,Cyclogalegenol,Astramembrangenin

Target: Epigenetic Reader Domain, Telomerase

Cat.No: T78497

Cat.No: T38499

1-Oxohederagenin

Cat.No: TN5996

Synonym: 1-氧代常春藤皂苷元,3β,23-Dihydroxy-1-oxo-olean-12-en-28-oic acid

3-O-α-L-Rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl hederagenin28-O-β-D-xylopyranosyl-(1→6)-β-D-glucopyranosyl ester

Cat.No: T83345

4'-Methoxyresveratrol

Cat.No: T5716

Synonym: 白藜芦醇-4'-甲醚,4'-O-Methylresveratrol

Target: advanced glycation end products

D-Ribose(mixture of isomers)

Cat.No: T4786

Synonym: D-Ribose,D-(-)-Ribose,D-(-)-核糖

Target: Others, Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02927	RAGE Protein, Human, Recombinant (His) RAGE,advanced glycosylation end product-specific re...	Human	HEK293 Cells
	RAGE Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35.5 kDa and the accession number is A0A1U9X785.
TMPY-02881	RAGE Protein, Human, Recombinant RAGE,advanced glycosylation end product-specific re...	Human	HEK293 Cells
	RAGE Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 35 kDa and the accession number is A0A1U9X785.
TMPY-01716	RAGE Protein, Human, Recombinant (hFc) RAGE,advanced glycosylation end product-specific re...	Human	HEK293 Cells
	RAGE Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.1 kDa and the accession number is A0A1U9X785.
TMPY-01675	RAGE Protein, Mouse, Recombinant (His) advanced glycosylation end product-specific receptor,RAG...	Mouse	HEK293 Cells
	RAGE Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35.3 kDa and the accession number is Q62151-1.
TMPK-00479	AGER Protein, Cynomolgus, Recombinant (His) AGER,RAGE,SCARJ1	Cynomolgus	HEK293 Cells
	The receptor for advanced glycation end products (AGER) is an oncogenic transmembranous receptor up-regulated in various human cancers. AGER promotes proliferation, migration, and inhibits apoptosis of squamous cervical cancer and might function as a tumor promoter in cervical cancer. Our study provides novel evidence for a potential role of AGER in bridging human papillomavirus (HPV)-induced inflammation and cervical cancer.

重组蛋白

RAGE Protein, Human, Recombinant (His)

Cat.No: TMPY-02927

Species: Human

Expression System: HEK293 Cells

RAGE Protein, Human, Recombinant

Cat.No: TMPY-02881

Species: Human

Expression System: HEK293 Cells

RAGE Protein, Human, Recombinant (hFc)

Cat.No: TMPY-01716

Species: Human

Expression System: HEK293 Cells

RAGE Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01675

Species: Mouse

Expression System: HEK293 Cells

AGER Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00479

Species: Cynomolgus

Expression System: HEK293 Cells

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