Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7167 |
Purvalanol B
NG 95,(2R)-2-[[6-[(3-氯-4-羧基苯基)氨基]-9-(1-甲基乙基)-9H-嘌呤-2-基]氨基]-3-甲基-1-丁醇 |
CDK; Parasite | Cell Cycle/Checkpoint; Microbiology/Virology |
Purvalanol B (NG 95) 是选择性可逆的 ATP 竞争性 CDK 抑制剂。它在一系列其他蛋白激酶 (IC50>1000 nM) 中显示出对 CDK 的选择性。它抑制耐氯喹菌株 P. falciparum 的生长。 | |||
T13454 |
(S)-Purvalanol B
(S)-NG 95 |
BCL | Apoptosis |
(S)-Purvalanol B 是 Purvalanol B 的 S 对映体,Purvalanol B 是一种细胞周期蛋白依赖性激酶(CDK)抑制剂。 | |||
T2059 |
Purvalanol A
NG-60 |
Apoptosis; CDK; Autophagy | Apoptosis; Autophagy; Cell Cycle/Checkpoint |
Purvalanol A (NG-60) 是一种CDK 抑制剂,对 cdc2-cyclin B、cdc2-cyclin B、cdk2-cyclin E、cdk4-cyclin D1 和 cdk5-p35 的IC50值分别为 4、70、35、850 和 75 nM。 | |||
T71230 |
VMY-1-103
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VMY-1-103 is a potent CDK inhibitor, is also a novel dansylated analog of purvalanol B, was shown to inhibit cell cycle progression and proliferation in prostate and breast cancer cells more effectively than purvalanol B. VMY-1-103 , but not purvalanol B, significantly decreased the proportion of cells in S phase and increased the proportion of cells in G(2)/M. VMY-1-103 increased the sub G(1) fraction of apoptotic cells, induced PARP and caspase-3 cleavage and increased the levels of the Death ... | |||
T71231 |
VMY-1-101
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VMY-1-101 is a synthesized fluorescent CDK inhibitor. VMY-1-101 demonstrates potent CDK inhibitory activity, enhanced induction of G2/M arrest and modest apoptosis as compared to purvalanol B. |