Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6960 |
PU-H71
|
HSP | Cytoskeletal Signaling; Metabolism |
PU-H71是一种选择性的HSP90抑制剂,IC50= 51 nM。 | |||
T6960L |
PU-H71 HCl
PU-H71 HCl(873436-91-0 Free base),Zelavespib HCl |
HSP; DNA/RNA Synthesis | Cell Cycle/Checkpoint; Cytoskeletal Signaling; DNA Damage/DNA Repair; Metabolism |
PU-H71 HCl (Zelavespib HCl) 是一种新型Hsp90抑制剂,是一种新型嘌呤基类似物,也是一种可能是CIRT的一种有前途的放射增敏剂。PU-H71 HCL 在许多恶性肿瘤临床前模型中显示出抗肿瘤活性。PU-H71 HCL 对 Rad51 和Ku70 的蛋白表达水平有抑制作用,这可能与双链断裂修复的同源重组途径和非同源末端连接途径有关。 | |||
T71247 |
PU-H71 hydrate
|
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PU-H71 hydrate is a potent inhibitor of heat shock protein 90 (Hsp90). | |||
T80742 |
Zelavespib hydrochloride
PU-H71 hydrochloride |
HSP | Cytoskeletal Signaling; Metabolism |
Zelavespib (PU-H71) hydrochloride is a potent Hsp90 inhibitor with an IC50 of 51 nM in MDA-MB-468 cells. | |||
T71245 |
ARRY-502
|
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ARRY-502 is a CRTH2 antagonist. Regulation of cytokine activity is important in molecularly targeted therapies for asthma. | |||
T70270 |
SMTIN-P01
|
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SMTIN-P01 is a mitochondria-targeted Hsp90 inhibitor. It is made from the isopropyl amine of the Hsp90 inhibitor PU-H71 being replaced with the mitochondria-targeting moiety triphenylphosphonium. | |||
T69712 |
Icapamespib HCl
|
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Icapamespib, also known as PU-HZ 151, is a heat shock protein 90 (HSP90) inhibitor. PU-HZ151 showed EC50 of 5 nM in the FP assay as compared to 11 nM for PU-H71 and a logD of 2.37 as compared to 1.21 for PU-H71. PU-HZ151 and radiolabeled PU-HZ151 showed selectivity for epichaperomes over the individual chaperome members. Icapamespib demonstrated the ability to productively engage the target in cells, mice, and humans. |