40
2
12
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9691L |
(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate
|
Thyroid hormone receptor(THR) | Endocrinology/Hormones |
(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate 是一种高效的甲状旁腺激素 (PTH) 拮抗剂,在牛肾皮质膜中的 Ki 值为 69 nM。 | |||
T9691 |
(D-Trp12,Tyr34)-pTH (7-34) amide (bovine)
|
||
(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) 在生命科学相关研究中具有广泛的应用。 | |||
T76657 |
Human PTH-(1-31)
|
||
Human PTH-(1-31) 是人PTH的第1至31个氨基酸片段。它能够促进cAMP的释放,并作为25-羟基维生素D-1α-羟化酶的弱激活剂。此外,Human PTH-(1-31) 能够促进骨生成,而不引起骨质吸收,表明其在骨质疏松症研究中的应用潜力。 | |||
T76660 |
pTH (1-37) (human)
|
||
pTH (1-37) (human) 为甲状旁腺激素(PTH)的一段,能诱导cAMP产生并提升碱性磷酸酶活性,进而增强尿毒症动物的生长速度、骨钙含量及骨矿物质密度(BMD),显示出对骨质疏松症研究的应用潜力。 | |||
T81352 |
pTH (2-38) (human)
|
||
pTH (2-38) (human) 促进骨骼合成代谢,并能增加血清中INS-PTH(完整N末端特异性PTH)的水平。 | |||
T76657L |
Human PTH-(1-31) amide
|
||
Human PTH-(1-31) amide 是PTH类似物,能够刺激磷脂酰胆碱水解并促进腺苷酸环化酶的释放。 | |||
T13128 |
Teriparatide
特立帕肽,Human parathyroid hormone-(1-34),hPTH (1-34),PTH 1-34 |
Others | Others |
Teriparatide is an agonist of PHT(IC50 of 2 nM in HEK293 cells). | |||
T76663 |
pTH-Related Protein (1-40) (human, mouse, rat)
|
||
pTH-Related Protein (1-40) (human, mouse, rat) 促进大鼠肠细胞通过PTHR1受体和PKCα/β信号通路的钙吸收作用。该蛋白增加了甲状旁腺激素1受体(PTHR1)表达,提升了四种跨膜钙转运蛋白—TRPV6、CaBP-D9k、NCX1和PMCA1的水平。 | |||
T81351 |
pTH-Related Protein (1-34) amide (human, mouse, rat)
Human PTHrP-(1-34)NH2 |
||
pTH-Related Protein (1-34) amide (human, mouse, rat) 为PTHrP的N末端片段,能够诱导高钙血症,适于研究与恶性肿瘤相关的体液性高钙血症。 | |||
T81350 |
pTH-Related Protein (1-37) (human, mouse, rat)
|
||
pTH-Related Protein (1-37) (human, mouse, rat) 为甲状旁腺相关蛋白 (pTHrP) 的肽段,涉及骨形成的生理调控过程。 | |||
T76636 |
(Tyr36)-pTH-Related Protein (1-36) (human, mouse, rat)
|
||
'(Tyr36)-pTH-Related Protein (1-36) (human, mouse, rat)'是用于甲状旁腺激素(PTH)受体的肽类配体。 | |||
T81349 |
pTH-Related Protein (7-34) amide (human, mouse, rat)
|
||
pTH-Related Protein (7-34) amide (human, mouse, rat) 为一种高效的甲状旁腺激素 (PTH) 拮抗剂。 | |||
T76586 |
(Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat)
|
||
(Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) 是一种有效的 PTH-1R 拮抗剂。 | |||
T8344 |
CPTH2
|
Apoptosis; Histone Acetyltransferase | Apoptosis; Chromatin/Epigenetic |
CPTH2 是一种组蛋白乙酰基转移酶抑制剂。它选择性地抑制Gcn5对组蛋白 H3 的乙酰化,通过抑制乙酰转移酶p300 (KAT3B)诱导凋亡并降低透明细胞肾癌细胞系的侵袭性。 | |||
TP1602 |
[pThr3]-CDK5 Substrate
|
||
[pThr3]-CDK5 Substrate is an effective Phospho-Thr3CDK5 Substrate.[pThr3]-CDK5 Substrate is phosphorylated by CDK5 with a Km value of 6 µM[1]. | |||
T77990 |
Human PTHrP-(1-36)
|
||
Human PTHrP-(1-36) 为PTHrP的分泌形式,具抗尿酸效应,并能促进β细胞功能与增殖。该化合物可应用于研究恶性肿瘤体液性高钙血症(HHM)及甲状旁腺功能亢进症。 | |||
T19830 |
Dicapthon
AC4124,AC 4124,Captex,ENT-17035,ENT 17035,AC-4124 |
||
Dicapthon is an insecticide. Dicapthon increases the occurrence of abnormal cell frequency, decreases the mitotic index, and decreases the nuclear division index. | |||
TP1660 |
[pThr3]-CDK5 Substrate (TFA)
|
||
[pThr3]-CDK5 Substrate TFA is an effective Phospho-Thr3CDK5 Substrate. [pThr3]-CDK5 Substrate is phosphorylated by CDK5 with a Km value of 6 µM. | |||
T22693 |
CPTH2 (hydrochloride) (357649-93-5 free base)
CPTH2 (hydrochloride) |
Others | Others |
CPTH2 is an inhibitor of the HAT activity of Gcn5. | |||
T76031 |
[pThr3]-CDK5 Substrate TFA
|
||
[pThr3]-CDK5 Substrate TFA 是 Thr3 磷酸化的CDK5底物。[pThr3]-CDK5 Substrate 来自组蛋白 H1,位于组蛋白 H1 上和CDK5作用的位点。CDK5Substrate 被CDK5磷酸化为 [pThr3]-CDK5 Substrate 的 Km 为 6 μM。 | |||
T25397 |
Ethyl dicapthon
AI310615,AI3 10615,AI3-10615 |
||
Ethyl dicapthon is used as an insecticide. | |||
TP1906L1 |
DPC AJ1951 acetate
|
Thyroid hormone receptor(THR) | Endocrinology/Hormones |
DPC-AJ1951 acetate 是一种 14 个氨基酸的肽,可作为甲状旁腺激素 (PTH)/PTH 相关肽受体 (PPR) 的有效激动剂。在骨吸收的体外和体内测定中表征了它的活性。 | |||
T29067 |
Upacicalcet
PLS-240,SK-1403,AJT-240 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Upacicalcet (AJT-240) 是一种静脉内拟钙剂,是一种可用于人血液透析的 SHPT, 通过直接作用于甲状旁腺细胞膜钙敏感受体来抑制过量的甲状旁腺激素 (PTH) 分泌,从而降低血液中的 PTH 水平。 3 Upacicalcet 是钙敏感受体的正变构调节剂,可预防大鼠腺嘌呤诱导的继发性甲状旁腺功能亢进模型中的血管钙化和骨骼疾病。 | |||
T16015 |
Maxacalcitol
马沙骨化醇,22-Oxacalcitriol |
Others | Others |
Maxacalcitol (22-Oxacalcitriol) 是非血钙维生素 D3的一种类似物,是 VDR 样受体的配体。 | |||
T29067L |
Upacicalcet HCl
Upacicalcet HCl(1333218-50-0 Free base) |
CaSR | GPCR/G Protein |
Upacicalcet HCl 是一种静脉内拟钙剂,通过直接作用于甲状旁腺细胞膜钙敏感受体来抑制过量的甲状旁腺激素 (PTH) 分泌,从而降低血液中的 PTH 水平。Upacicalcet HCl 可用于治疗血液是一种新型继发性甲状旁腺功能亢进化合物,靶向钙敏感受体的氨基酸结合位点。 | |||
T21535 |
Parathyroid Hormone (1-34), bovine
|
Thyroid hormone receptor(THR) | Endocrinology/Hormones |
Parathyroid Hormone (1-34), bovine 是一种甲状旁腺激素 (PTH) 受体激动剂,是甲状旁腺激素的一部分。 Parathyroid Hormone (1-34), bovine 可用于研究骨质疏松症和甲状旁腺功能衰退。 | |||
TP1236 |
Etelcalcetide hydrochloride
AMG 416 hydrochloride,维考西肽盐酸盐,KAI-4169 hydrochloride |
CaSR | GPCR/G Protein |
Etelcalcetide hydrochloride (AMG 416 hydrochloride) 是具有有钙敏感受体 (CaSR) 活化剂作用的合成肽,能够减少接受血液透析的继发性甲状旁腺功能亢进患者的甲状旁腺激素 (PTH) 浓度。 | |||
T75942 |
DPC-AJ1951 TFA
|
||
DPC-AJ1951 TFA,是一种含有14个氨基酸的肽类化合物,有效充当甲状旁腺激素(PTH)/PTH相关肽受体(PPR)激动剂,在体外及体内骨吸收实验中展现活性。 | |||
T61232 |
(Rac)-Upacicalcet
|
||
(Rac)-Upacicalcet is a racemate of Upacicalcet, which serves as an intravenous calcimimetic agent. Upacicalcet acts by directly targeting calcium-sensing receptors on parathyroid cell membranes, effectively suppressing the release of excessive parathyroid hormone (PTH) and reducing blood PTH levels. This compound holds the potential for researching secondary hyperparathyroidism (SHPT) [1]. | |||
T36767 | Parathyroid Hormone (1-13) (trifluoroacetate salt) | ||
Parathyroid hormone (PTH) (1-13) is an N-terminal fragment of PTH (1-34) . In vivo, PTH (1-13) (0.003-1 μmol/kg) increases mean arterial pressure (MAP) in anesthetized rats. | |||
TP1964 |
Parathyroid hormone (1-34) (rat)
|
||
Parathyroid hormone (PTH) receptor agonist. Increases serum PTH levels and bone mass in rats. | |||
T75867 |
Parathyroid Hormone (1-34), bovine TFA
|
||
Parathyroid Hormone (1-34), bovine TFA,作为一种高效的甲状旁腺激素(PTH)受体激动剂,能提升钙和无机磷酸盐的水平,适用于骨质疏松症的研究。 | |||
T39444 |
Upacicalcet sodium
|
||
Upacicalcet (sodium) is an intravenous calcimimetic agent that acts directly on parathyroid cell membrane calcium-sensing receptors to suppress excessive parathyroid hormone (PTH) secretion, thereby lowering blood PTH levels. It is indicated for the research of secondary hyperparathyroidism (SHPT). | |||
T37409 |
DPC-AJ1951 (trifluoroacetate salt)
DPC-AJ1951 (trifluoroacetate salt) |
||
DPC-AJ1951 is a peptide agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR; EC50 = 0.15 nM in HEK293 cells expressing human PPR). It induces cAMP production in SAOS-2 and UMR106 cells that endogenously express human and rat PPR, respectively (EC50s = 2.2 and 1.1 nM, respectively). DPC-AJ1915 stimulates osteoclast-mediated bone resorption in fetal rat long-bone explant cultures and increases collagen synthesis and cell proliferation in neonatal mouse parietal bone explants... | |||
T36919 |
1α-Hydroxy-3-epi-vitamin D3
1α-Hydroxy-3-epi-vitamin D3 |
||
1α-Hydroxy-3-epi-vitamin D3, a natural metabolite derived from 1alpha,25-dihydroxyvitamin D3, effectively suppresses parathyroid hormone (PTH) secretion[1]. | |||
T73692 |
Parathyroid hormone
|
||
Parathyroid hormone (PTH) 是一种含84个氨基酸的循环激素,由甲状旁腺分泌。它主要针对骨骼和肾脏工作,功能是维持细胞外钙浓度在正常水平。此外,Parathyroid hormone 在骨质疏松症的研究中有重要应用。 | |||
TP1906 |
DPC-AJ1951
DPC AJ1951 |
||
Potent 14 amino acid peptide agonist of the parathyroid hormone (PTH) receptor (EC50 = 26 nM). | |||
TP1688 |
TIP 39, Tuberoinfundibular Neuropeptide
|
||
This is a tuberoinfundibular neuropeptide and parathyroid hormone 2(PTH 2)-receptor agonist from hypothalmus. Synthetic TIP39 activates human and rat PTH2 receptors. | |||
TP2283 |
parathyroid hormone (7-34) [Homo sapiens]/[Macaca fascicularis]
|
Others | Others |
parathyroid hormone (7-34) [Homo sapiens] [Macaca fascicularis] is a peptide with the sequence H2N-LMHNLGKHLNSMERVEWLRKKLQDVHNF-OH, MW= 3474.03. Parathyroid hormone (PTH) is secreted by the chief cells of the parathyroid glands as a polypeptide containing | |||
T35500 |
3-epi-25-hydroxy Vitamin D3
3-epi-25-hydroxy Vitamin D3 |
||
3-epi-25-hydroxy Vitamin D3is the C-3 epimer of 25-hydroxy vitamin D3.1Dietary administration of 3-epi-25-hydroxy vitamin D3(0.5 and 1 IU/g) decreases levels of serum parathyroid hormone (PTH) in male, but not female, weanling rats. 1.Djekic-Ivankovic, M., Lavery, P., Agellon, S., et al.The C-3α epimer of 25-hydroxycholecalciferol from endogenous and exogenous sources supports normal growth and bone mineral density in weanling ratsJ. Nutr.147(2)141-151(2017) |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6430 |
Calcifediol
25-羟基维生素 D3,U 32070E,25-hydroxy Vitamin D3,RO 8-8892,骨化二醇 |
Endogenous Metabolite | Metabolism |
Calcifediol (U 32070E) 是由维生素 D3 在肝中经羟基化后得到的前激素,是 VDR 的有效抑制剂。 | |||
T16442 |
PCO371
2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl- |
Thyroid hormone receptor(THR) | Endocrinology/Hormones |
PCO371 (2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl-) 是口服具有活性的甲状旁腺激素受体 1 的完全激动剂,对 PTHR2 无作用 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00740 |
PTH Protein, Human, Recombinant
PTH,Parathyrin,Parathyroid Hormone,Parathormone |
Human | E. coli |
Parathyroid hormone is the most important endocrine regulator of calcium and phosphorus concentration in extracellular fluid. This hormone is secreted from cells of the parathyroid glands and finds its major target cells in bone and kidney. Another hormone, parathyroid hormone-related protein, binds to the same receptor as parathyroid hormone and has major effects on development. Like most other protein hormones, parathyroid hormone is synthesized as a preprohormone. After intracellular processi... | |||
TMPY-03191 |
PTH Protein, Human, Recombinant (hFc)
PTH,parathyroid hormone,PTH1 |
Human | HEK293 Cells |
PTH Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 37.9 kDa and the accession number is P01270. | |||
TMPY-02764 |
PTH Protein, Human, Recombinant (aa 32-65, GST)
parathyroid hormone,PTH1,PTH |
Human | E. coli |
PTH Protein, Human, Recombinant (aa 32-65, GST) is expressed in E. coli expression system with GST tag. The predicted molecular weight is 31 kDa and the accession number is P01270. | |||
TMPJ-00741 |
PTH Protein, Human, Recombinant (His)
Parathyroid hormone,Parathyrin,PTH,Parathormone |
Human | HEK293 Cells |
Parathyroid hormone (PTH) is a critical hormone in the regulation of Ca++ homeostasis. Parathyroid hormone is the most important endocrine regulator of calcium and phosphorus concentration in extracellular fluid. This hormone is secreted from cells of the parathyroid glands and finds its major target cells in bone and kidney. Another hormone, parathyroid hormone-related protein, binds to the same receptor as parathyroid hormone and has major effects on development. Like most other protein hormon... | |||
TMPY-03572 |
PTRH2 Protein, Human, Recombinant (His)
PTH 2,PTH2,peptidyl-tRNA hydrolase 2,CGI-1... |
Human | E. coli |
PTH2, also known as PTRH2, is a mitochondrial protein that belongs to the PTH2 family. PTH 2 is released during apoptosis from the mitochondria to the cytoplasm. The natural substrate for PTH 2 may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. When in the cytoplasm, PTRH2 regulates the function of 2 transcriptional regulators, TLE5 and TLE1, thus promoting caspase-independent cell death. | |||
TMPH-02434 |
PTH Protein, Cynomolgus, Recombinant (His & Myc)
|
Cynomolgus | E. coli |
PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells. PTH Protein, Cynomolgus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 16.9 kDa and the accession number is Q9XT35. | |||
TMPH-03348 |
PTH Protein, Rat, Recombinant (His & Myc)
|
Rat | E. coli |
PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells. PTH Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 16.9 kDa and the accession number is Q9XT35. | |||
TMPY-02236 |
PTH1R Protein, Human, Recombinant (His)
PFE,PTHR1,MGC138452,parathyroid hormone 1 receptor,... |
Human | HEK293 Cells |
Parathyroid hormone / parathyroid hormone-related peptide receptor, also known as PTH / PTHrP type I receptor, PTH/PTHr receptor, Parathyroid hormone 1 receptor, PTH1 receptor, PTH1R and PTHR, is a multi-pass membrane protein which belongs to the G-protein coupled receptor 2 family. PTH1R is expressed in most tissues. It is most abundant in kidney, bone and liver. PTH1R is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase an... | |||
TMPH-01848 |
PTHLH Protein, Human, Recombinant (His)
|
Human | E. coli |
PTHLH Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 19.7 kDa and the accession number is P12272. | |||
TMPH-03293 |
FGF-23 Protein, Rat, Recombinant (E. coli, His)
|
Rat | E. coli |
Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Regulator of vitamin-D metabolism. Negatively regulates osteoblasts differentiation and matrix mineralization. Acts directly on the parathyroid to decrease PTH secretion. Upregulates EGR1 expression in the presence of KL. | |||
TMPH-03294 |
FGF-23 Protein, Rat, Recombinant (His)
|
Rat | P. pastoris (Yeast) |
Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Regulator of vitamin-D metabolism. Negatively regulates osteoblasts differentiation and matrix mineralization. Acts directly on the parathyroid to decrease PTH secretion. Upregulates EGR1 expression in the presence of KL. FGF-23 Protein, Rat, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 27.5 kDa and the accession number is Q8VI82. | |||
TMPJ-00464 |
APE Protein, Human, Recombinant
APEX,Apurinic-Apyrimidinic Endonuclease 1,APEN,DNA-(Apurinic... |
Human | E. coli |
Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases, APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors, which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors, such as c-Jun, c-Fos, NF-kB, p53. APEN is also involved in calcium-dependent down... |