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Targets Recommended: p38 MAPK PI3K Src mTOR

2

抑制剂 & 化合物

1

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T6732 WYE-687

N-[4-[4-(4-吗啉基)-1-[1-(3-吡啶甲基)-4-哌啶基]-1H-吡唑并[3,4-D]嘧啶-6-基]苯基]氨基甲酸甲酯

p38 MAPK; PI3K; Src; mTOR Angiogenesis; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
WYE-687 是 ATP 竞争性的 mTOR 抑制剂,其 IC50=7 nM。它能够抑制PI3Kα和PI3Kγ,IC50分别为 81 nM 和 3.11 μM。它能够抑制mTORC1和mTORC2活化。
T36089 RMC-5552

RMC-5552 is a potent and selective inhibitor of mTORC1. RMC-5552 inhibits phosphorylation of mTORC1 pS6K and p4EBP1 with IC50s of 0.14 nM and 0.48 nM, respectively. RMC-5552 has anti-cancer activity.

化合物

WYE-687
Cat.No: T6732
Synonym: N-[4-[4-(4-吗啉基)-1-[1-(3-吡啶甲基)-4-哌啶基]-1H-吡唑并[3,4-D]嘧啶-6-基]苯基]氨基甲酸甲酯
Target: p38 MAPK, PI3K, Src, mTOR
RMC-5552
Cat.No: T36089
Synonym:
Target:
Cat. No. Product Name Species Expression System
TMPY-04540 S6K1/RPS6KB1 Protein, Human, Recombinant (GST)

p70(S6K)-alpha,PS6K,p70-alpha,p70...

Human Baculovirus Insect Cells
PS6K, also known as RPS6KB1, is a serine/threonine-protein kinase. It belongs to the RSK (ribosomal s6 kinase) family. Members of this family function in signal transduction. PS6K is an isoform of p70 ribosomal S6 kinase (S6K). S6K can be activated by mitogenic stimuli such as growth factors, insulin and cytokines. It phosphorylates the ribosomal protein S6. PS6K also phosphorylates other proteins such as elF4B, eEF2K and SKAR. It is a crucial effector of mTOR(rapamycin) signaling. PS6K is disso...

重组蛋白

S6K1/RPS6KB1 Protein, Human, Recombinant (GST)
Cat.No: TMPY-04540
Species: Human
Expression System: Baculovirus Insect Cells
TargetMol Loading
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