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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T20615	Olsalazine 奥沙拉嗪,Dipentium,Salicylic acid	Others	Others
	Olsalazine (Dipentium) 是一种抗炎药，用于治疗炎症性肠病。它也是一种新型的 DNA 去甲基化剂。
T22946	LY255283 LY 255283	Leukotriene Receptor	GPCR/G Protein
	LY255283 是白三烯 B4 (LTB4) 受体的特异性拮抗剂，抑制人外周血多形核白细胞和由钙离子载体 A23187 激活的单核细胞中 LTB(4) 的产生。
T37618	Leukotriene B4 dimethyl amide Leukotriene B4 dimethyl amide
	LTB4 dimethyl amide is a moderate inhibitor of LTB4-induced degranulation of human neutrophils (Ki = 130 nM) and lysozyme release from rat PMNL. LTB4 dimethyl amide appears to be an antagonist of the LTB4 receptor on guinea pig lung membranes.
T37649	5(S),12(S)-DiHETE
	5(S),12(S)-DiHETE is a natural bioactive lipid derived from arachidonic acid . It is synthesized by glycogen-induced rabbit peritoneal polymorphonuclear leukocytes (PMNLs) incubated with AA. 5(S),12(S)-DiHETE can be produced by successive oxygenation of AA by 5-lipoxygenase (5-LO) in platelets and 12-LO in leukocytes. It can also be synthesized from 12(S)-HETE by 5-LO, in the presence of 5-LO activating protein (FLAP), activated with calcium ionophore. 5(S),12(S)-DiHETE is an epimer of leukotrie...
T37650	5(S),15(S)-DiHETE
	5(S),15(S)-DiHETE is synthesized by 15-LO from 5(S)-HETE. It potentiates the degranulation of human PMNL in response to PAF, but not fMLP, calcium ionophore A23187, or LTB4. 5(S),15(S)-DiHETE is chemotactic for eosinophils with an ED50 value of 0.3 μM.
T37400	15(S)-HETrE
	15(S)-HETrE is the hydroxy-trienoic acid resulting from 15-lipoxygenation of dihomo-γ-linolenic acid . It is an inhibitor of 5-LO in human PMNL with an IC50 value of 4.6 μM. In RBL cells, 15(S)-HETrE inhibits 5-LO, but is about 1/20 as potent as 15(S)-HpETE.
T38087	20-hydroxy Leukotriene B4 20-hydroxy Leukotriene B4
	20-hydroxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. 20-hydroxy LTB4 is not only much less active (~5%) compared to LTB4 in causing degranulation of PMNL, but actually inhibits LTB4-induced degranulation of human neutrophils (Ki = 13.3 nM). However, 20-hydroxy LTB4 is as active as LTB4 in contracting parenchymal strips from guinea pig lung. 20-hydroxy LTB4 retains considerable ligand binding affinity at the BLT2...

化合物

Olsalazine

Cat.No: T20615

Synonym: 奥沙拉嗪,Dipentium,Salicylic acid

Target: Others

LY255283

Cat.No: T22946

Synonym: LY 255283

Target: Leukotriene Receptor

Leukotriene B4 dimethyl amide

Cat.No: T37618

Synonym: Leukotriene B4 dimethyl amide

20-hydroxy Leukotriene B4

Cat.No: T38087

Synonym: 20-hydroxy Leukotriene B4

Target:

Cat. No.	Product Name	Target	Signaling Pathways
T4114	Diffractaic Acid NSC 5901,地弗地衣酸,NSC 685595	Apoptosis; LTR	Apoptosis; Immunology/Inflammation
	Diffractaic Acid (NSC 685595) 是松萝的主要成分，具有止痛和解热效果，在各种疾病研究中可作为有效的促凋亡剂。