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Search Results for " plp "

Targets Recommended: Others

18

抑制剂 & 化合物

3

天然产物

16

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
TP1312L	[SER140]-PLP(139-151) acetate [SER140]-PLP(139-151) acetate (122018-58-0 Free base)	Others	Others
	[SER140]-PLP(139-151) acetate 是来自髓鞘蛋白脂蛋白 (PLP) 的肽片段。
TP1282	PLP (139-151) PLP 139-151
	PLP (139-151) is amino acid residue residue 139 to 151 of myelin proteolipid protein (PLP). This peptide is used to induce relapsing-remitting (RR)-EAE model.
TP1312	[SER140]-PLP(139-151)
	[SER140]-PLP(139-151) is a polypeptide fragment of the lipid protein of myelin.
TP1402	[SER140]-PLP(139-151) TFA (122018-58-0 free base) [SER140]-PLP(139-151) TFA
	[SER140]-PLP(139-151) (TFA) is a polypeptide fragment of the myelin lipid protein.
T81439	PLP (178-191)
	PLP (178-191) 是具有生物活性的肽段，为蛋白脂质蛋白(PLP)中的一部分，范围涵盖氨基酸178至191。在SJL小鼠中，PLP作为免疫显性致脑炎表位，是两个主要致脑炎表位之一。与另一致脑炎肽段PLP(139-151)相比，PLP (178-191)可导致更早的疾病发作时间，尽管在发病率、疾病严重性和组织学特征方面与之不具区分性。
T64674	Plp(139-151) trifluoroacetate
	Plp(139-151) trifluoroacetate 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64674。
T81438	PLP (180-199)
	PLP (180-199) 是一种具备生物活性的肽段，为髓磷脂蛋白（PLP）中氨基酸 180 至 199 的区域。作为中枢神经系统中含量最高的髓磷脂蛋白，PLP (180-199) 在多发性硬化症（MS）的研究中具有重要应用，MS 为一种以中枢神经系统慢性炎症性脱髓鞘为特征的疾病。
T83690	[Leu144, Arg147]-PLP (139-151) TFA [Leu144, Arg147] Proteolipid Peptide (139-151),H-His-Ser-Leu-Gly-Lys-Leu-Leu-Gly-Arg-Pro-Asp-Lys-Phe-OH
	[Leu144,Arg147]-PLP (139-151)是髓鞘脂蛋白(PLP)的一种突变肽段，包含位于144和147位置的色氨酸到亮氨酸以及组氨酸到精氨酸的替换。使用[Leu144, Arg147]-PLP (139-151)（50 µg）乳化于完全弗氏佐剂(CFA)免疫后，能增加小鼠脾脏中的IL-4水平。它在体外抑制Th1细胞激活，但在体内不抑制，其中它诱导调节性T细胞的产生。用[Leu144, Arg147]-PLP (139-151)预免疫可以延迟由脑炎肽PLP (178-191)、髓磷脂少突细胞蛋白(MOG) (92-106)或髓鞘基础蛋白(MBP)在小鼠中诱导的实验性自身免疫性脑炎(EAE)的发病。
T61500	PLP_Snyder530
	PLP_Snyder530 是一种有效的类木瓜蛋白酶 (PLpro) 抑制剂。PLP_Snyder530 诱导 SARS-COV-2 木瓜蛋白酶样蛋白酶的构象变化，抑制 SARS-COV-2 复制。PLP_Snyder530 可用于 SARS-CoV-2 研究。
T78704	PLpro/RBD-IN-1	SARS-CoV	Microbiology/Virology
	PLpro/RBD-IN-1 为 SARS-CoV-2 PLpro 与刺突蛋白 RBD的双重抑制剂，具有抗新型冠状病毒的活性，看用于研究病毒感染。
T12502	PLpro inhibitor 5-(乙酰氨基)-2-甲基-N-[(1R)-1-(1-萘基)乙基]苯甲酰胺	SARS-CoV	Microbiology/Virology
	PLpro inhibitor 是一种木瓜蛋白酶抑制剂，IC50为 2.6 µM，能抑制 SARS-CoV-2 PLpro。
T62991	Mpro/PLpro-IN-1
	Mpro/PLpro-IN-1 (Compound 29) 是一种双重作用的 SARS-CoV-2 蛋白酶抑制剂。Mpro/PLpro-IN-1 也是一种 Mpro/PLpro 的有效抑制剂，对 M pro 具有微摩尔抑制作用（IC50:1.72 μM），对 PL pro 具有亚微摩尔抑制作用（IC50:0.67 μM）。
T3578L	Pyridoxal calcium phosphate
	Pyridoxal phosphate (PLP, pyridoxal 5'-phosphate, P5P), known as an active form of vitamin B6, is a coenzyme involved in many enzymatic reactions.
T29033	U-7524 2-Aminooxyacetic acid,U 7524,Aminooxyacetic acid,U7524,AOAA
	U-7524, also known as AOAA and Aminooxyacetic acid, is an inhibitor of 4-aminobutyrate aminotransferase (GABA-T). AOAA is also a general inhibitor of pyridoxal phosphate (PLP)-dependent enzymes (this includes GABA-T). It functions as an inhibitor by attac
T82020	J5 peptide Myelin basic protein (85-99) antagonist
	J5 peptide是MBP抑制剂，竞争性阻断MBP85-99与HLA-DR2的结合。该肽段能减轻PLP139-151/MBP85-99诱导的小鼠实验性自身免疫性脑脊髓炎(EAE)。J5 peptide主要用于研究炎症和免疫疾病。
T73614	Tyrosine decarboxylase
	Tyrosine decarboxylase (TDC; TyrDC)，即酪氨酸脱羧酶，广泛存在于植物、昆虫和不同微生物中，常用于生化研究。Tyrosine decarboxylase 是一种5'-磷酸吡哆醛 (PLP) 依赖性脱羧酶，可以催化酪氨酸中羧基的去除，产生酪胺和二氧化碳。
T71174	PBT434 HBr
	PBT434 is a novel, brain-penetrant, small molecule inhibitor of α-synuclein aggregation. In transgenic animal models of Parkinson disease (A53T) and MSA (PLP-α-Syn), PBT434 reduced α-synuclein aggregation, preserved neurons and improved motor function. Glial cell inclusions were also reduced in a murine MSA model. PBT434 is thought to act by redistributing reactive iron across membranes, thereby blocking intracellular protein aggregation and oxidative stress. The affinity of PBT434 for iron is g...
T79929	L-Methionine γ-lyase Methionine lyase
	L-Methionine γ-lyase（Methionine lyase）是一种依赖磷酸吡哆醛的多功能酶，专门催化L-蛋氨酸（L-methionine）及其类似物的α, γ-裂解反应。该酶因其抗癌和抗感染活性被用于相关疾病的研究，同时也适用于同型半胱氨酸血症研究领域。

化合物

[SER140]-PLP(139-151) acetate

Cat.No: TP1312L

Synonym: [SER140]-PLP(139-151) acetate (122018-58-0 Free base)

Target: Others

PLP (139-151)

Cat.No: TP1282

Synonym: PLP 139-151

[SER140]-PLP(139-151)

Cat.No: TP1312

[SER140]-PLP(139-151) TFA (122018-58-0 free base)

Cat.No: TP1402

Synonym: [SER140]-PLP(139-151) TFA

PLP (178-191)

Cat.No: T81439

Plp(139-151) trifluoroacetate

Cat.No: T64674

PLP (180-199)

Cat.No: T81438

[Leu144, Arg147]-PLP (139-151) TFA

Cat.No: T83690

Synonym: [Leu144, Arg147] Proteolipid Peptide (139-151),H-His-Ser-Leu-Gly-Lys-Leu-Leu-Gly-Arg-Pro-Asp-Lys-Phe-OH

PLP_Snyder530

Cat.No: T61500

PLpro/RBD-IN-1

Cat.No: T78704

Target: SARS-CoV

PLpro inhibitor

Cat.No: T12502

Synonym: 5-(乙酰氨基)-2-甲基-N-[(1R)-1-(1-萘基)乙基]苯甲酰胺

Target: SARS-CoV

Mpro/PLpro-IN-1

Cat.No: T62991

Pyridoxal calcium phosphate

Cat.No: T3578L

Cat.No: T29033

Synonym: 2-Aminooxyacetic acid,U 7524,Aminooxyacetic acid,U7524,AOAA

Cat.No: T82020

Synonym: Myelin basic protein (85-99) antagonist

Tyrosine decarboxylase

Cat.No: T73614

Cat.No: T71174

L-Methionine γ-lyase

Cat.No: T79929

Synonym: Methionine lyase

Cat. No.	Product Name	Target	Signaling Pathways
T3578	Pyridoxal phosphate PLP,PAL-P,磷酸吡哆醛,pyridoxal 5'-phosphate,Pyridoxyl phosphate,Pyridoxal 5′-phosphate,Vitamin B6 phosphate	Reverse Transcriptase; Endogenous Metabolite	Metabolism; Microbiology/Virology
	Pyridoxal phosphate (Vitamin B6 phosphate) 是维生素 B6 的活性形式，可抑制逆转录酶活性，用于研究迟发性运动障碍症。
T5085	Pyridoxal 5'-phosphate hydrate Codecarboxylase,Pyridoxal 5'-phosphate hydrate(1:x),5-磷酸吡多醛水合物,PLP,Pyridoxal 5'-phosphate hydrate	Others; Endogenous Metabolite	Metabolism; Others
	Pyridoxal 5'-phosphate hydrate (PLP) 是内源性代谢产物的一种。
T8083	Pyridoxal 5'-phosphate monohydrate Pyridoxal phosphate monohydrate,Pyridoxal 5-phosphate monohydrate,5-磷酸吡哆醛	Others	Others
	Pyridoxal 5'-phosphate monohydrate 是维生素 B6的活性形式，也是多种酶的重要辅因子。它是维生素 B6 在细胞内磷酸化过程中重要的辅酶变异体，能够与其他变异体（如 PNP 、 PMP）发生互换。

天然产物

Pyridoxal phosphate

Cat.No: T3578

Synonym: PLP,PAL-P,磷酸吡哆醛,pyridoxal 5'-phosphate,Pyridoxyl phosphate,Pyridoxal 5′-phosphate,Vitamin B6 phosphate

Target: Reverse Transcriptase, Endogenous Metabolite

Pyridoxal 5'-phosphate hydrate

Cat.No: T5085

Synonym: Codecarboxylase,Pyridoxal 5'-phosphate hydrate(1:x),5-磷酸吡多醛水合物,PLP,Pyridoxal 5'-phosphate hydrate

Target: Others, Endogenous Metabolite

Pyridoxal 5'-phosphate monohydrate

Cat.No: T8083

Synonym: Pyridoxal phosphate monohydrate,Pyridoxal 5-phosphate monohydrate,5-磷酸吡哆醛

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00082	PLP-C beta Protein, Rat, Recombinant (His) Prlpc2,PLP-C β Protein, Rat, Recombinant (His),prol...	Rat	HEK293 Cells
	PLP-C beta Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.8 kDa and the accession number is A0A0M6L0Y1.
TMPY-06767	Complement C3 Protein, Mouse, Recombinant (His) HSE-MSF,complement component 3,Plp,AI255234,ASP	Mouse	HEK293 Cells
	Complement C3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.34 kDa and the accession number is NP_033908.2.
TMPY-02208	Peroxiredoxin 5 Protein, Human, Recombinant (His) B166,HEL-S-55,prx-V,ACR1,PMP20,AOEB166,SBBI10,PRXV,peroxired...	Human	E. coli
	Peroxiredoxin 5 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 18.5 kDa and the accession number is P30044-2.
TMPJ-00933	PRDX5 Protein, Human, Recombinant (His) Antioxidant enzyme B166,Alu corepressor 1,Peroxiredoxin-5,	Human	HEK293 Cells
	Peroxisomes are essential organelles that participate in multiple important metabolic processes, including the β-oxidation of fatty acids, plasmalogen synthesis, and the metabolism of reactive oxygen species (ROS). Peroxiredoxins is overexpressed in breast cancer tissues to a great extent suggesting that they has a proliferative effect and may be related to cancer development or progression. Peroxiredoxin 5 (PRDX5) is a thioredoxin peroxidase that belongs to the atypical 2-Cys class of the TSA/a...
TMPH-01722	PLP1 Protein, Human, Recombinant (His)	Human	E. coli
	This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin. PLP1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 35.5 kDa and the accession number is P60201.
TMPY-04693	APLP1 Protein, Mouse, Recombinant (His) amyloid β (A4) precursor-like protein 1,amyloid beta (A4) pr...	Mouse	HEK293 Cells
	APLP1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 62.4 kDa and the accession number is Q03157.
TMPK-00935	APLP2 Protein, Human, Recombinant (His) APPL2,YWK-II,APPH,CDEI box-binding,CDEBP	Human	HEK293 Cells
	Amyloid β precursor-like protein 2 (APLP2) has been determined to serve an important role in the progression of a number of cancer types. APLP2 expression was significantly associated with disease-specific survival (P<0.001). APLP2 may be used to potentially predict patient prognosis, and to guide clinical diagnosis and treatment in CCRCC.
TMPY-03628	APLP1 Protein, Human, Recombinant (His) amyloid beta (A4) precursor-like protein 1,APLP,amy...	Human	HEK293 Cells
	APLP1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 61.9 kDa and the accession number is P51693-1.
TMPK-01352	SARS-CoV-2 PLpro/papain-like protease Protein (His & Avi) Plpro,PL2-PRO,pp1a,nsp1,Replicase polyprotein 1a,Pa...	SARS	E. coli
	The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro and 3CLpro are to process the viral polyprotein in a coordinated manner, PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. SARS-CoV-2 PLpro/papain-like protease Pro...
TMPK-01384	SARS PLpro/papain-like protease Protein (His) Papain-like Protease,PL-PRO,Replicase polyprotein 1a,pp1a,PL...	SARS	E. coli
	The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro and 3CLpro are to process the viral polyprotein in a coordinated manner, PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. SARS PLpro/papain-like protease Protein (...
TMPH-00865	RPLP0 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Ribosomal protein P0 is the functional equivalent of E.coli protein L10. RPLP0 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 50.3 kDa and the accession number is P05388.
TMPY-05356	RPLP1 Protein, Human, Recombinant (His) LP1,ribosomal protein, large, P1,P1,RPP1	Human	Baculovirus Insect Cells
	RPLP1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 13.8 kDa and the accession number is A0A024R608.
TMPH-02483	RPLP0 Protein, Mouse, Recombinant (His & Myc & SUMO)	Mouse	E. coli
	Ribosomal protein P0 is the functional equivalent of E.coli protein L10. RPLP0 Protein, Mouse, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10XHis-SUMO and C-Myc tag. The predicted molecular weight is 54.2 kDa and the accession number is P14869.
TMPY-05682	SARS-CoV-2 Plpro/papain-like protease Protein (aa 1564-1880, His)	SARS-CoV-2	E. coli
	SARS-CoV-2 Plpro/papain-like protease Protein (aa 1564-1880, His) is expressed in E. coli expression system. The predicted molecular weight is 36.79 kDa and the accession number is QVD65746.1.
TMPY-04894	SARS-CoV (strain WH20) Plpro/papain-like protease (His)	SARS	E. coli
	SARS-CoV (strain WH20) Plpro/papain-like protease (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 36.65 kDa and the accession number is AAX16193.1.
TMPH-02870	PDXP Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Functions as a pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP and therefore plays a role in vitamin B6 metabolism. Also functions as a protein serine phosphatase that specifically dephosphorylates 'Ser-3' in proteins of the actin-depolymerizing factor (ADF)/cofilin family like CFL1 and DSTN. Thereby, regulates cofilin-dependent actin cytoskel...

重组蛋白

PLP-C beta Protein, Rat, Recombinant (His)

Cat.No: TMPY-00082

Species: Rat

Expression System: HEK293 Cells

Complement C3 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-06767

Species: Mouse

Expression System: HEK293 Cells

Peroxiredoxin 5 Protein, Human, Recombinant (His)

Cat.No: TMPY-02208

Species: Human

Expression System: E. coli

PRDX5 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00933

Species: Human

Expression System: HEK293 Cells

PLP1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01722

Species: Human

Expression System: E. coli

APLP1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-04693

Species: Mouse

Expression System: HEK293 Cells

APLP2 Protein, Human, Recombinant (His)

Cat.No: TMPK-00935

Species: Human

Expression System: HEK293 Cells

APLP1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03628

Species: Human

Expression System: HEK293 Cells

SARS-CoV-2 PLpro/papain-like protease Protein (His & Avi)

Cat.No: TMPK-01352

Species: SARS

Expression System: E. coli

SARS PLpro/papain-like protease Protein (His)

Cat.No: TMPK-01384

Species: SARS

Expression System: E. coli

RPLP0 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-00865

Species: Human

Expression System: E. coli

RPLP1 Protein, Human, Recombinant (His)

Cat.No: TMPY-05356

Species: Human

Expression System: Baculovirus Insect Cells

RPLP0 Protein, Mouse, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-02483

Species: Mouse

Expression System: E. coli

SARS-CoV-2 Plpro/papain-like protease Protein (aa 1564-1880, His)

Cat.No: TMPY-05682

Species: SARS-CoV-2

Expression System: E. coli

SARS-CoV (strain WH20) Plpro/papain-like protease (His)

Cat.No: TMPY-04894

Species: SARS

Expression System: E. coli

PDXP Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02870

Species: Mouse

Expression System: E. coli

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