Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T64052 |
PI3K-IN-27
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PI3K-IN-27 是 PI3K 的有效抑制剂。PI3K 是脂质信号激酶大家族,在细胞生长、分化、迁移和细胞凋亡等细胞过程中发挥着关键作用。PI3K-IN-27 对癌症和炎症等过度增殖性疾病或免疫和自身免疫性疾病表现出研究潜力。 | |||
T1916 |
Apitolisib
RG 7422,GNE 390,GDC-0980 |
Apoptosis; PI3K; mTOR | Apoptosis; PI3K/Akt/mTOR signaling |
Apitolisib (RG 7422) 是一种口服有效的 PI3K 和 mTOR(TORC1/2) 激酶抑制剂,抑制 PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ的活性,IC50值为 5 nM/27 nM/7 nM/14 nM,抑制 mTOR,Ki 为 17 nM。它用于乳腺癌、前列腺癌、肾细胞癌和子宫内膜癌等实体癌的试验研究 。 | |||
T78853 |
PI3K-IN-47
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PI3K | PI3K/Akt/mTOR signaling |
PI3K-IN-47 (Compound 27) 是一款高度选择性的二价PI3K抑制剂,对PI3Kα具有极低的半抑制浓度(IC50: 0.44 nM), 同时对PI3Kβ、PI3Kγ、PI3Kδ也表现出良好的抑制活性(IC50分别为7.18 nM、13.92 nM、22.83 nM)。此化合物能够有效诱导细胞周期在G1期发生暂停,并且在体外抑制集落形成和细胞迁移。对于HGC-27异种移植的小鼠模型,PI3K-IN-47能够显著抑制肿瘤生长。 | |||
T61656 |
Antitumor agent-53
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Antitumor agent-53 is a potent compound that effectively inhibits tumor growth. It achieves this by inducing cell cycle arrest at the G2/M phase and promoting apoptosis in HGC-27 cells through the inhibition of the PI3K/AKT pathway. Furthermore, Antitumor agent-53 holds promise for further research in the treatment of gastrointestinal tumors [1]. | |||
T35491 |
3,5-dimethyl PIT-1
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PtdIns-(3,4,5)-P3 (PIP3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as phosphatidylinositol 3-kinase (PI3K) or PTEN. Protein binding to PIP3 is important for cytoskeletal rearrangement and membrane trafficking and initiates an intricate signaling cascade that has been implicated in cancer. 3,5-dimethyl PIT-1 is a dimethyl analog of PIT-1, the selective inhibitor of PIP3/Akt PH domain binding, that is designed for more favorab... |