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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10960 |
Darbufelone
达布非酮,CI-1004 |
Prostaglandin Receptor; LTR | GPCR/G Protein; Immunology/Inflammation |
Darbufelone (CI-1004) 是 PGF2α 和 LTB4 的非竞争性双重抑制剂。 Dabfilon 有效抑制 PGHS-2,对 PGHS-2 和 PGHS-1 的 Ki 为 10 μM,IC50 为 0.19 μM 和 20 μM。 | |||
T10960L |
Darbufelone mesylate
CI-1004 mesylate |
Prostaglandin Receptor; LTR | GPCR/G Protein; Immunology/Inflammation |
Darbufelone mesylate (CI-1004 mesylate) 对细胞中 PGF2α 和 LTB4 产生有抑制作用。Darbufelone mesylate 对 PGHS-2 有抑制作用,IC50 值为 0.19 μM,对 PGHS-1 的IC50 值为 20 μM。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01736 |
COX-2 Protein, Human, Recombinant (His)
GRIPGHS,PHS-2,hCox-2,COX-2 |
Human | Baculovirus Insect Cells |
PTGS2, also known as COX-2, is s component of Prostaglandin-endoperoxide synthase (PTGS). PTGS, also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. PTGS2 is overexpressed in many cancers. The overexpression of PTGS2 along with increased angiogenesis and GLUT-1 expression ... |