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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T29813	AL-3138 AL3138,AL 3138,11-Deoxy-16-fluoro PGF2alpha
	AL-3138 is a prostaglandin F2alpha (PGF2alpha) analogue which antagonizes FP prostanoid receptor-mediated inositol phosphates generation.
T22285	Carboprost 15(S)-15-Methyl Prostaglandin F2α,15-Methyl-PGF2α,卡前列素	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Carboprost (15(S)-15-Methyl Prostaglandin F2α) 是一种前列腺素 F2α 的代谢稳定的合成类似物。它能够刺激子宫收缩并引起流产，可用于子宫收缩乏力引起的产后出血，以及在妊娠中期终止妊娠。
T30452	Bimatoprost isopropyl ester 17-phenyl trinor PGF2α-iPr,17-phenyl trinor PGF2α isopropyl ester
	Bimatoprost isopropyl ester is an F-series prostaglandin analog, which has been approved as a hypotensive drug.
T4546	Dinoprost tromethamine salt Dinoprost Tromethamine,Zinoprost,Prostin F2 alpha,PGF2α THAM,Dinolytic,地诺前列素氨丁三醇,Prostaglandin F2α THAM	Apoptosis; Endogenous Metabolite; Prostaglandin Receptor; Autophagy; PROTAC Linker	Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; Metabolism; PROTAC
	Dinoprost tromethamine salt (PGF2α THAM) 是一种口服有效的前列腺素 F 受体激动剂。它是在子宫内膜腔上皮和黄体中局部产生的溶酶激素，在分娩过程中起关键作用。
T29725	AGN-191129 AGN191129,Prostaglandin F2α alcohol methyl ether,PGF2α-OMe,UNII-NK1168QB5T
	AGN-191129, also known as Prostaglandin F2α alcohol methyl ether (PGF2α-OMe), is an analog of PGF2α in which the C-1 carboxyl group has been replaced by an O-methyl ether. The compound is reported to retain ocular hypotensive properties, but the receptors
T37326	Prostaglandin F2α 1,11-lactone Prostaglandin F2α 1,11-lactone,PGF2α 1,11-lactone	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Prostaglandin F2α 1,11-lactone (PGF2α 1,11-lactone) 是前列腺素 F2α 的脂溶性前药，可用于治疗青光眼的研究。 Prostaglandin F2α 1,11-lactone 作为抗生育剂具有活性，可大大降低血管活性。
T37991	15-keto Prostaglandin F2α 15-keto Prostaglandin F2α,15-keto PGF2α	Endogenous Metabolite; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism
	15-keto Prostaglandin F2α 是 Prostaglandin F2α 的代谢物，可降低兔眼压。
T36146	13,14-dihydro Prostaglandin F2α 13,14-dihydro Prostaglandin F2α,13,14-dihydro PGF2α
	13,14-dihydro Prostaglandin F2α (13,14-dihydro PGF2α) is the analog of PGF2α which has no unsaturation in the lower side chain. It causes luteolysis in hamsters with a potency five times higher than PGF2α. The ED50 value for 13,14-dihydro PGF2α as a luteolytic agent in hamsters is 1.5 &#181g/100 g.[1]
T28251	ONO-8809 ONO8809
	ONO-8809 is a thromboxane A2 receptor antagonist. ONO-8809 inhibited the LTC4-induced airway hyperresponsiveness to histamine in a dose-dependent manner. Macrophage accumulation and matrix metalloproteinase-9 (MMP-9) activity in the stroke-negative area i

化合物

AL-3138

Cat.No: T29813

Synonym: AL3138,AL 3138,11-Deoxy-16-fluoro PGF2alpha

Target:

Carboprost

Cat.No: T22285

Synonym: 15(S)-15-Methyl Prostaglandin F2α,15-Methyl-PGF2α,卡前列素

Target: Prostaglandin Receptor

Bimatoprost isopropyl ester

Cat.No: T30452

Synonym: 17-phenyl trinor PGF2α-iPr,17-phenyl trinor PGF2α isopropyl ester

Target:

Dinoprost tromethamine salt

Cat.No: T4546

Synonym: Dinoprost Tromethamine,Zinoprost,Prostin F2 alpha,PGF2α THAM,Dinolytic,地诺前列素氨丁三醇,Prostaglandin F2α THAM

Target: Apoptosis, Endogenous Metabolite, Prostaglandin Receptor, Autophagy, PROTAC Linker

AGN-191129

Cat.No: T29725

Synonym: AGN191129,Prostaglandin F2α alcohol methyl ether,PGF2α-OMe,UNII-NK1168QB5T

Target:

Prostaglandin F2α 1,11-lactone

Cat.No: T37326

Synonym: Prostaglandin F2α 1,11-lactone,PGF2α 1,11-lactone

Target: Prostaglandin Receptor

15-keto Prostaglandin F2α

Cat.No: T37991

Synonym: 15-keto Prostaglandin F2α,15-keto PGF2α

Target: Endogenous Metabolite, Prostaglandin Receptor

13,14-dihydro Prostaglandin F2α

Cat.No: T36146

Synonym: 13,14-dihydro Prostaglandin F2α,13,14-dihydro PGF2α

Cat. No.	Product Name	Target	Signaling Pathways
T15133	Dinoprost Prostaglandin F2a,PGF2α,地诺前列素	Endogenous Metabolite	Metabolism
	Dinoprost (Prostaglandin F2a) 是口服有效的、内源性的前列腺素 F 受体激动剂。它是在子宫内膜腔上皮和黄体中局部产生的溶酶激素。它在分娩过程中起关键作用。
T20939	Bimatoprost acid 17-phenyl trinor PGF2α,17-phenyl trinor Prostaglandin F2α	GPR	Endocrinology/Hormones; GPCR/G Protein
	Bimatoprost acid (17-phenyl trinor PGF2α) 是一种代谢稳定的 PGF2α 类似物，对 FP 受体具有潜在的拮抗活性。与 PGF2α 相比，它与绵羊黄体细胞上的 FP 受体结合的相对效力为 756%。

天然产物

Dinoprost

Cat.No: T15133

Synonym: Prostaglandin F2a,PGF2α,地诺前列素

Target: Endogenous Metabolite

Bimatoprost acid

Cat.No: T20939

Synonym: 17-phenyl trinor PGF2α,17-phenyl trinor Prostaglandin F2α

Target: GPR

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