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Search Results for " p18 "

Targets Recommended: Thrombin

16

抑制剂 & 化合物

10

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T80097	Hirullin P18	Thrombin	Proteases/Proteasome
	Hirullin P18 作为一种高效的凝血酶抑制剂，展现出显著的抗凝作用。
T24580	P18IN003 P18IN 003,P18IN-003	CDK	Cell Cycle/Checkpoint
	P18IN003 是一种具有选择性和有效性的 p18(INK4C) 抑制剂，可抑制 p18 蛋白的活性可用于研究造血干细胞的体外扩增。
T8576	P18IN011 P18IN011 - CAS 77408-67-4 - Calbiochem	CDK	Cell Cycle/Checkpoint
	P18IN011 (P18IN011 - CAS 77408-67-4 - Calbiochem) 是一种新型 p18(INK4C) 抑制剂。
T16914	SP187 UV4,MON-DNJ	Others; Virus Protease; Influenza Virus	Microbiology/Virology; Others
	SP187 (MON-DNJ) 是一种靶向作用于宿主的亚氨基糖。它具有抗丝状病毒感染活性。SP187可用于治疗抗流感和登革热病毒。
T2032	WHI-P180 Janex 3	EGFR; VEGFR; c-RET; CDK	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	WHI-P180 (Janex 3) 是 EGFR 和 Cdk2 抑制剂，IC50 分别为 4.0 和 1.0 μM。
T24582	p18SMI-21 p18SMI 21
	p18SMI-21 is a novel INK4C inhibitor. It also specifically blocking the bioactivity of p18 protein.
T24581	P18IN005 HCl P18IN-005 HCl,P18IN 005,P18IN005
	P18IN005 HCl is a novel inhibitor of the p18.
T24583	p18SMI-41 p18SMI 41
	p18SMI-41 is a novel INK4C inhibitor. It also specifically blocking the bioactivity of p18 protein.
T39009	CAP18 (rabbit) CAP18 (rabbit)
	CAP18 (rabbit) is a 37 amino acid antimicrobial peptide derived from rabbit granulocytes. It exhibits extensive antimicrobial activity against both Gram-positive (IC50, 130-200 nM) and Gram-negative (IC50, 20-100 nM) bacteria. Thus, CAP18 (rabbit) holds promise for the study and advancement of bacterial sepsis research.
T28283	p18SMI-22 p18SMI 22
	p18SMI-22 is an INK4C inhibitor.
T14297	AP1867	Others	Others
	AP1867 is a synthetic FKBP12F36V-directed ligand.
T61007	WHI-P180 hydrochloride
	WHI-P180 (Janex 3) 抑制RET, KDR 和EGFR 的IC50值分别为5 nM，66 nM 和4 μM。WHI-P180 是一种多种激酶抑制剂。
T18611	AP1867-2-(carboxymethoxy) PROTAC FKBP12-binding moiety 2	Others	Others
	AP1867-2-(carboxymethoxy), a moiety based on the synthetic FKBP12F36V-directed ligand AP1867, connects to the CRBN ligand through a linker to generate dTAG molecules[1].
T13549	AP1867-3-(aminoethoxy)	Others	Others
	AP1867-3-(aminoethoxy) is a synthetic ligand for FKBP and can be used in the synthesis of PROTAC FKBP12 F36V degrader.
T3589	NSC23005 Sodium	CDK	Cell Cycle/Checkpoint
	NSC23005 sodium 是新型 p18 抑制剂 (ED50=5.21 nM)，在小鼠和人类模型中促进造血干细胞扩增。
T29166	XIE18-6 XIE186
	XIE18-6, a novel INK4C inhibitor, specifically blocks the bioactivity of p18 protein and promotes human and murine hematopoietic stem cell ex vivo expansion.

化合物

Cat.No: T80097

Target: Thrombin

Cat.No: T24580

Synonym: P18IN 003,P18IN-003

Target: CDK

Cat.No: T8576

Synonym: P18IN011 - CAS 77408-67-4 - Calbiochem

Target: CDK

Cat.No: T16914

Synonym: UV4,MON-DNJ

Target: Others, Virus Protease, Influenza Virus

Cat.No: T2032

Synonym: Janex 3

Target: EGFR, VEGFR, c-RET, CDK

Cat.No: T24582

Synonym: p18SMI 21

Cat.No: T24581

Synonym: P18IN-005 HCl,P18IN 005,P18IN005

Cat.No: T24583

Synonym: p18SMI 41

Cat.No: T39009

Synonym: CAP18 (rabbit)

Cat.No: T28283

Synonym: p18SMI 22

Cat.No: T14297

Target: Others

WHI-P180 hydrochloride

Cat.No: T61007

AP1867-2-(carboxymethoxy)

Cat.No: T18611

Synonym: PROTAC FKBP12-binding moiety 2

Target: Others

AP1867-3-(aminoethoxy)

Cat.No: T13549

Target: Others

NSC23005 Sodium

Cat.No: T3589

Target: CDK

Cat.No: T29166

Synonym: XIE186

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00963	CDKN2C Protein, Human, Recombinant (His) Cyclin-Dependent Kinase 4 Inhibitor C,p18-INK4c,CDK...	Human	E. coli
	Cyclin-Dependent Kinase 4 Inhibitor C (CDKN2C) is a member of the INK4 family of cyclin dependent kinase inhibitors. CDKN2C contains 4 ANK repeats and interacts with CDK4 or CDK6. Highest levels of CDKN2C can be found in skeletal muscle, pancreas, and heart. CDKN2C inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB and prevent the activation of the CDK kinases. Studies have been shown the roles of CDKN2C gene in regulating spermatogenesis,...
TMPY-02019	CD59 Protein, Human, Recombinant (His) MIN2,MAC-IP,G344,EL32,FLJ92039,HRF-20,EJ30,HRF20,MSK21,MGC23...	Human	HEK293 Cells
	CD59 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 10.2 kDa and the accession number is P13987-1.
TMPH-01288	Elongin-B Protein, Human, Recombinant (GST) EloB,Elongin-B,TCEB2,ELOB,SIII p18	Human	E. coli
	SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region ...
TMPY-02608	UBC9/UBE2I Protein, Human, Recombinant UBC9,ubiquitin-conjugating enzyme E2I,C358B7.1,P18	Human	E. coli
	UBE2I is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed nowadays to be crucial for a wider range of cellular processes. The outcome of the ubiquitin-conjugation reaction, and thereby the fate of the substrate, is heavily dependent on the number of ubiquitin molecules attached and how these ubiquitin molecules are inter-connected. To d...
TMPY-04110	TPPP2 Protein, Human, Recombinant (His) P18,p25β,CT152,tubulin polymerization-promoting pro...	Human	E. coli
	TPPP2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 20.3 kDa and the accession number is AAH38970.1.
TMPY-03976	EEF1E1 Protein, Human, Recombinant (His) eukaryotic translation elongation factor 1 ε 1,P18,...	Human	E. coli
	EEF1E1, also known as AIMP3 and p18, is a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, EEF1E1 is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. It is comprised of a bifunctional glutamyl-prolyl-tRNA synthase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl and aspartyl-tRNA synthases, and three auxiliary proteins, EEF1E1/p18, AIMP2/p38 and AIMP1/p43. EEF1E1 also plays a positive role in ATM/AT...
TMPJ-00675	ZNHIT1 Protein, Human, Recombinant (His) ZNFN4A1,CGBP1,inc finger HIT domain-containing protein 1,cyc...	Human	E. coli
	ZNHIT1 belongs to the ZNHIT1 family and contains one HIT-type zinc finger. It can be phosphorylated on Thr by MAPK11 or MAPK14. ZNHIT1 is a component of the chromatin-remodeling SRCAP complex, which is composed of at least SRCAP, DMAP, RUVBL1, RUVBL2, ACTL6A, YEATS4, ACTR6 and ZNHIT1. ZNHIT1 may play a role in p53-mediated apoptosis induction.
TMPJ-01053	UBE2I Protein, Human, Recombinant (GST) SUMO-Protein Ligase,Ubiquitin-Conjugating Enzyme E2 I,p1...	Human	E. coli
	SUMO-Conjugating Enzyme UBC9 (UBC9) belongs to the ubiquitin-conjugating enzyme family. UBC9 is homologous to ubiquitin-conjugating enzymes (E2s). However, instead of conjugating ubiquitin, UBC9 conjugates a ubiquitin homologue, Small Ubiquitin-Like Modifier 1 (SUMO-1). The conjugation of ubiquitin requires the activities of ubiquitin-activating (E1) and conjugating (E2) enzymes. It is suggested that UBC9 might play a role in DNA repair and perhaps even in aging.
TMPH-03133	HSP18.1 Protein, Pisum sativum, Recombinant (His & SUMO)	Pisum sativum	E. coli
	N/A. HSP18.1 Protein, Pisum sativum, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 34.1 kDa and the accession number is P19243.
TMPH-02283	USP18 Protein, Human, Recombinant (His)	Human	E. coli
	USP18 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 47.1 kDa and the accession number is Q9UMW8.

重组蛋白

CDKN2C Protein, Human, Recombinant (His)

Cat.No: TMPJ-00963

Species: Human

Expression System: E. coli

CD59 Protein, Human, Recombinant (His)

Cat.No: TMPY-02019

Species: Human

Expression System: HEK293 Cells

Elongin-B Protein, Human, Recombinant (GST)

Cat.No: TMPH-01288

Species: Human

Expression System: E. coli

UBC9/UBE2I Protein, Human, Recombinant

Cat.No: TMPY-02608

Species: Human

Expression System: E. coli

TPPP2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04110

Species: Human

Expression System: E. coli

EEF1E1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03976

Species: Human

Expression System: E. coli

ZNHIT1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00675

Species: Human

Expression System: E. coli

UBE2I Protein, Human, Recombinant (GST)

Cat.No: TMPJ-01053

Species: Human

Expression System: E. coli

HSP18.1 Protein, Pisum sativum, Recombinant (His & SUMO)

Cat.No: TMPH-03133

Species: Pisum sativum

Expression System: E. coli

USP18 Protein, Human, Recombinant (His)

Cat.No: TMPH-02283

Species: Human

Expression System: E. coli

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