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Search Results for " oxytocin receptor "

38

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T4996	Atosiban 阿托西班,RWJ22164,RW22164	Oxytocin Receptor; Vasopressin Receptor	Endocrinology/Hormones; GPCR/G Protein
	Atosiban (RW22164) 是一种脱氨基催产素类似物，是一种九肽，也是竞争性的催产素受体拮抗剂。它是一种宫缩抑制剂，可用于自发早产的研究。
T11857	LIT-001	Oxytocin Receptor	Endocrinology/Hormones; GPCR/G Protein
	LIT-001 是非肽类催产素受体激动剂，EC50为55 nM，Ki 为226 nM。它可改善孤独症小鼠模型的社交互动。
T5148	Atosiban acetate RW22164,Atosiban acetate (90779-69-4 free base),RWJ22164,醋酸阿托西班	Oxytocin Receptor; Vasopressin Receptor	Endocrinology/Hormones; GPCR/G Protein
	Atosiban acetate (RW22164) 是一种脱氨基催产素类似物，是一种九肽，也是竞争性的催产素受体拮抗剂。它是一种宫缩抑制剂，可用于自发早产的研究。
T12331L	OT-R antagonist 1 Oxytocin receptor antagonist 1	Others	Others
	OT-R antagonist 1 inhibits oxytocin-evoked intracellular Ca2+ mobilization (IC50 = 8 nM). OT-R antagonist 1 is a new effective and selective nonpeptide low molecular weight OT-R antagonist.
T12331	OT-R antagonist 2 Oxytocin receptor antagonist 2	Others	Others
	OT-R antagonist 2 is a nonpeptide low molecular weight antagonist of OT-R .
T7601L	Carbetocin acetate 醋酸卡贝缩宫素,Carbetocin acetate(37025-55-1 free base),卡贝缩宫素醋酸盐	Oxytocin Receptor	Endocrinology/Hormones; GPCR/G Protein
	Carbetocin acetate 是催产素类似物，是催产素受体激动剂，Ki 是 7.1 nM。它对催产素受体的嵌合 N 末端具有高亲和力，Ki 为 1.17 μM。它能透过血脑屏障，可以通过激活 CNS 中的催产素受体而具有类抗抑郁活性，具有用于产后出血的研究潜力。
T7601	Carbetocin 卡贝缩宫素,醋酸卡贝缩宫素	Oxytocin Receptor	Endocrinology/Hormones; GPCR/G Protein
	Carbetocin 是催产素类似物，是催产素受体激动剂，Ki 是 7.1 nM。它对催产素受体的嵌合 N 末端具有高亲和力，Ki 为 1.17 μM。它能透过血脑屏障，可以通过激活 CNS 中的催产素受体而具有类抗抑郁活性，具有用于产后出血的研究潜力。
T21534L	Oxytocin C-terminal tripeptide Acetate Oxytocin C-terminal tripeptide Acetate(2002-44-0 Free base)	Others	Others
	Oxytocin C-terminal tripeptide Acetate 是 Oxytocin 的 C-末端三肽。Oxytocin 是哺乳动物的神经垂体激素，催产素受体的配体。
T3347	PF3274167 PF 3274167,Cligosiban,PF-3274167	OX Receptor	GPCR/G Protein; Neuroscience
	PF3274167 (Cligosiban) 是一种有效的、选择性的、高亲和力的非肽催产素受体拮抗剂。
T28855	SSR126768A SSR-126768A,SSR 126768A	Oxytocin Receptor	Endocrinology/Hormones; GPCR/G Protein
	SSR126768A 是一种新型且具有选择性、口服活性和有效性的催产素(OT)受体拮抗剂，对子宫收缩有抑制作用，可用于预防早产。
T15682	L-371,257	Oxytocin Receptor; Vasopressin Receptor	Endocrinology/Hormones; GPCR/G Protein
	L-371,257 是催产素受体的竞争性拮抗剂，pA2 为 8.4，Ki 为 19 nM。 L-371,257 对加压素受体 1a 的 Ki 值为 3.7 nM。
TP2082L	d[Cha4]-AVP acetate(500170-27-4 free base)	Vasopressin Receptor	GPCR/G Protein
	d[Cha4]-AVP acetate(500170-27-4 free base) 是一种有效的选择性人血管加压素 V1B 受体激动剂（V1B、V1A、催产素和 V2 受体的 Ki 值分别为 1.2、151、240 和 750 nM）。刺激 ACTH 和皮质酮分泌，并在体内表现出微不足道的血管加压活性。
T23441	TC OT 39	Others	Others
	oxytocin receptor partial agonist
T23528	WAY-267464	Others	Others
	oxytocin receptor (OTR) agonist
T11502	Epelsiban GSK 557296	Others	Others
	Epelsiban is a selective and orally bioavailable oxytocin receptor antagonist (pKi: 9.9 for human oxytocin receptor).
T28018	Merotocin FE202767,FE 202767,FE-202767
	Merotocin is a potent and highly selective peptidic agonist of the oxytocin receptor.
T69504	Barusiban
	Barusiban is an oxytocin receptor antagonist.
T24292	L 366948 L366,948,L-366948,L-366,948,L 366,948,L366948
	L 366948 is an antagonist of the oxytocin receptor.
T25902	Ota-vasotocin OVTA
	Ota-vasotocin is a ligand utilized in quantitative receptor autoradiography for oxytocin receptors.
T26602	ALS-I-41
	ALS-I-41 is a novel, potent and selective antagonist of oxytocin receptor.
T12904	SHR1653	Others	Others
	SHR1653 is a highly potent, selective and brain penetrated antagonist of oxytocin receptor (OTR)(IC50 of 15 nM for hOTR).
T80140	(Val3,Pro8)-Oxytocin	Oxytocin Receptor	Endocrinology/Hormones; GPCR/G Protein
	"(Val3,Pro8)-Oxytocin"为Gq依赖性途径的激动剂，同时作为β-arrestin结合及催产素受体（OXTR）内化作用的次级激动剂。
T79172	PF-06655075	Oxytocin Receptor	Endocrinology/Hormones; GPCR/G Protein
	PF-06655075为一新型非脑渗透性OT受体(oxytocin receptor)激动剂，具有显著提高对OT受体(oxytocin receptor)的选择性和药代动力学稳定性。PF-06655075可用作工具化合物，以研究外周OT在行为反应中的功能。
T11794	L-368,899 hydrochloride	Others	Others
	L-368,899 hydrochloride, used as a tocolytic agent, is a potent, selective, orally bioavailable, non-peptide oxytocin receptor antagonist, with IC50s of 8.9 nM and 26 nM for rat uterus and human uterus oxytocin receptor, respectively.
T31647	Epelsiban besylate GSK-557296B,GSK557296B
	Epelsiban Besylate is an oral drug that is a highly selective anamol oxytocin receptor antagonist.
T76265	(Thr4,Gly7)-Oxytocin
	(Thr4,Gly7)-Oxytocin，一种Oxytocin类似物，特异性激活OT受体。通过激活TRPV1通道及抑制K+通道，诱导眼下神经元兴奋。
T80136	Val9-Oxytocin	Vasopressin Receptor	GPCR/G Protein
	Val9-Oxytocin为完全抗拮抗加压素(1a)受体的化合物，其结构上是Oxytocin的衍生物，特点在于Gly9位点被Val9取代。
T80126	(d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin	Oxytocin Receptor	Endocrinology/Hormones; GPCR/G Protein
	'(d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin (OVT)' 是催产素受体的一种拮抗剂，主要应用于神经系统疾病的研究领域。
T76590	(d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin
	(d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin，是一种催产素受体拮抗剂，可消除 CA1 锥体神经元中催产素增强的抑制性突触后电流。
T81501	PF-06655075 TFA	Oxytocin Receptor	Endocrinology/Hormones; GPCR/G Protein
	PF-06655075(TFA)为PF-06655075的三氟乙酸（TFA）形态。该化合物是一种创新的非脑渗透性氧催产素（oxytocin receptor）受体激动剂，且对氧催产素受体具有较高的选择性，药代动力学稳定性得到显著增强。PF-06655075可用作工具化合物，以深入研究外围氧催产素受体在行为反应中的功能。
T70570	Erlosiban
	Erlosiban, also known as OBE001, is a novel, orally active nonpeptide oxytocin receptor antagonist under development for the treatment of preterm labor and improvement in embryo implantation and pregnancy rate in assisted reproductive technology (ART).
T24370	L-368899 free base L 368899,L 368,899,L368,899,L-368899,L368899,L-368,899
	L-368899 is a non-peptide and orally active antagonist of oxytocin receptor (IC50: 8.9 nM). It displays 40-fold selectivity over vasopressin V1a and V2 receptors (IC50: 370 and 570 nM respectively).
T11856	LIT-001 free base	Others	Others
	LIT-001 free base improves social interaction in a mouse model of autism. LIT-001 free base is the first nonpeptide oxytocin receptor (OT-R) agonist (EC50=55 nM; Ki=226 nM).
TP2082	d[Cha4]-AVP
	Potent and selective human vasopressin V1B receptor agonist (Ki values are 1.2, 151, 240 and 750 nM for V1B, V1A, Oxytocin and V2 receptors respectively). Stimulates ACTH and corticosterone secretion and exhibits negligible vasopressor activity in vivo.
TP1927	d[Leu4,Lys8]-VP
	Selective vasopressin V1B receptor agonist (Ki values are 0.16, 64, 100 and 3800 nM for V1B, oxytocin, V2 and V1A receptors respectively). Displays weak antidiuretic, vasopressor and in vitro oxytocic activities.
TP2136	(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin
	Selective vasopressin V1A receptor antagonist. Inhibits vasopressin and oxytocin-induced increases in intracellular calcium concentrations in vitro (IC50 values are 5 and 30 nM respectively). Exhibits potent and prolonged antivasopressor activity and indu
T79173	PF-06478939	Oxytocin Receptor	Endocrinology/Hormones; GPCR/G Protein
	PF-06478939为一种非脑渗透性肽类化合物，具有对催产素(OT)受体及加压素受体的激动效应，其EC50值分别为0.01 nM与0.078 nM。
T75933	d[Cha4]-AVP TFA
	d[Cha4]-AVP TFA 是一种有效的选择性加压素 (AVP)V1b 受体激动剂，对人V1b 受体的Ki 为 1.2 nM。d[Cha4]-AVP TFA 对 V1b 受体的选择性高于对人类 V1a 受体、V2 受体和催产素受体。

化合物

Cat.No: T4996

Synonym: 阿托西班,RWJ22164,RW22164

Target: Oxytocin Receptor, Vasopressin Receptor

Cat.No: T11857

Target: Oxytocin Receptor

Atosiban acetate

Cat.No: T5148

Synonym: RW22164,Atosiban acetate (90779-69-4 free base),RWJ22164,醋酸阿托西班

Target: Oxytocin Receptor, Vasopressin Receptor

OT-R antagonist 1

Cat.No: T12331L

Synonym: Oxytocin receptor antagonist 1

Target: Others

OT-R antagonist 2

Cat.No: T12331

Synonym: Oxytocin receptor antagonist 2

Target: Others

Carbetocin acetate

Cat.No: T7601L

Synonym: 醋酸卡贝缩宫素,Carbetocin acetate(37025-55-1 free base),卡贝缩宫素醋酸盐

Target: Oxytocin Receptor

Cat.No: T7601

Synonym: 卡贝缩宫素,醋酸卡贝缩宫素

Target: Oxytocin Receptor

Oxytocin C-terminal tripeptide Acetate

Cat.No: T21534L

Synonym: Oxytocin C-terminal tripeptide Acetate(2002-44-0 Free base)

Target: Others

Cat.No: T3347

Synonym: PF 3274167,Cligosiban,PF-3274167

Target: OX Receptor

Cat.No: T28855

Synonym: SSR-126768A,SSR 126768A

Target: Oxytocin Receptor

Cat.No: T15682

Target: Oxytocin Receptor, Vasopressin Receptor

d[Cha4]-AVP acetate(500170-27-4 free base)

Cat.No: TP2082L

Target: Vasopressin Receptor

Cat.No: T23441

Target: Others

Cat.No: T23528

Target: Others

Cat.No: T11502

Synonym: GSK 557296

Target: Others

Cat.No: T28018

Synonym: FE202767,FE 202767,FE-202767

Cat.No: T69504

Cat.No: T24292

Synonym: L366,948,L-366948,L-366,948,L 366,948,L366948

Cat.No: T25902

Synonym: OVTA

Cat.No: T26602

Cat.No: T12904

Target: Others

(Val3,Pro8)-Oxytocin

Cat.No: T80140

Target: Oxytocin Receptor

Cat.No: T79172

Target: Oxytocin Receptor

L-368,899 hydrochloride

Cat.No: T11794

Target: Others

Epelsiban besylate

Cat.No: T31647

Synonym: GSK-557296B,GSK557296B

(Thr4,Gly7)-Oxytocin

Cat.No: T76265

Val9-Oxytocin

Cat.No: T80136

Target: Vasopressin Receptor

(d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin

Cat.No: T80126

Target: Oxytocin Receptor

(d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin

Cat.No: T76590

PF-06655075 TFA

Cat.No: T81501

Target: Oxytocin Receptor

Cat.No: T70570

L-368899 free base

Cat.No: T24370

Synonym: L 368899,L 368,899,L368,899,L-368899,L368899,L-368,899

LIT-001 free base

Cat.No: T11856

Target: Others

Cat.No: TP2082

d[Leu4,Lys8]-VP

Cat.No: TP1927

(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin

Cat.No: TP2136

Cat.No: T79173

Target: Oxytocin Receptor

d[Cha4]-AVP TFA

Cat.No: T75933

Cat. No.	Product Name	Target	Signaling Pathways
T5145	Oxytocin acetate Oxytocic hormone acetate,α-Hypophamine acetate,Oxytocin acetate (50-56-6 free base),醋酸催产素	Oxytocin Receptor	Endocrinology/Hormones; GPCR/G Protein
	Oxytocin acetate (α-Hypophamine acetate) 是哺乳动物的神经垂体激素，是多效的下丘脑肽，是催产素受体的配体，有助于分娩、哺乳和亲社会行为。它可作为一种压力应对分子，具有抗炎、抗氧化剂和保护作用。
T5026	Oxytocin 催产素,α-Hypophamine,Oxytocic hormone,Oxytocin (Syntocinon)	Oxytocin Receptor	Endocrinology/Hormones; GPCR/G Protein
	Oxytocin (Oxytocin (Syntocinon)) 是哺乳动物的神经垂体激素，是多效的下丘脑肽，是催产素受体的配体，有助于分娩、哺乳和亲社会行为。它可作为一种压力应对分子，具有抗炎、抗氧化剂和保护作用。

天然产物

Oxytocin acetate

Cat.No: T5145

Synonym: Oxytocic hormone acetate,α-Hypophamine acetate,Oxytocin acetate (50-56-6 free base),醋酸催产素

Target: Oxytocin Receptor

Cat.No: T5026

Synonym: 催产素,α-Hypophamine,Oxytocic hormone,Oxytocin (Syntocinon)

Target: Oxytocin Receptor

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