Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1582 |
Naproxen
萘普生,(S)-Naproxen |
COX; Autophagy | Autophagy; Immunology/Inflammation; Neuroscience |
Naproxen ((S)-Naproxen) 是COX-1和COX-2的抑制剂,在细胞试验中IC50值分别为8.72 和5.15 μM。它是丙酸衍生物和非甾体抗炎药,具有抗炎、解热和镇痛活性。 | |||
T0855 |
(R)-Naproxen
|
COX | Immunology/Inflammation; Neuroscience |
(R)-Naproxen 是一种抗炎剂,具有解热和镇痛作用。酸及其钠盐都用于治疗急性痛风或痛经、肌肉骨骼疾病、类风湿性关节炎和其他风湿病。 | |||
T1582L |
Naproxen sodium
Miranax,Anaprox,RS-3650,Naprelan,萘普生钠 |
COX; Autophagy | Autophagy; Immunology/Inflammation; Neuroscience |
Naproxen sodium (Anaprox) 是COX 抑制剂,用于 COX-1 和 COX-2,具有镇痛和解热特性。 | |||
T20667 |
Racemic Naproxen
DL-Naproxen,DL Naproxen |
||
Racemic Naproxen is a biochemical substance. | |||
T69267 | Naproxen glucuronide | ||
Naproxen glucuronide is a nonsteroidal anti-inflammatory drug (NSAID) of the propionic acid class (the same class as ibuprofen) that relieves pain, fever, swelling, and stiffness. It is a nonselective COX inhibitor. | |||
T69474 | Naproxen ethyl ester | ||
Naproxen ethyl ester is a nonsteroidal anti-inflammatory drug (NSAID) of the propionic acid class (the same class as ibuprofen) that relieves pain, fever, swelling, and stiffness. It is a non-selective COX inhibitor. | |||
T16272 |
Naproxen etemesil
LT-NS 001,MX 1094 |
PDE | Metabolism |
Naproxen is a COX-1 and COX-2 inhibitor (IC50s: 8.72 and 5.15 μM, respectively in cell assay). Naproxen etemesil is a lipophilic and non-acidic prodrug of naproxen. It is hydrolyzed to pharmacologically active Naproxen once absorbed. | |||
T0556 |
6-Methoxy-2-naphthoic acid
Naproxen impurity O,6-Methoxy-2-naphthalenecarboxylic acid,6-甲氧基-2-萘甲酸 |
NMDAR; iGluR | Membrane transporter/Ion channel; Neuroscience |
6-Methoxy-2-naphthoic acid (6-Methoxy-2-naphthalenecarboxylic acid) 是NMDA 受体调节剂。 | |||
T33595 |
Naproxcinod
AZD3582,Nitronaproxen,AZD-3582,Naproxen-N-butyl nitrate,HCT3012,AZD 3582 |
||
Naproxcinod, a nitric oxide-releasing NSAID derivative, significantly improved skeletal muscle strength and fatigue resistance in sedentary and exercise mice, reducing inflammatory infiltration and fibrotic deposition in the myocardium and diaphragm. In a | |||
T7662 |
α-Demethylnaproxen
|
COX | Immunology/Inflammation; Neuroscience |
α-Demethylnaproxen 是一种 COX 的竞争性抑制剂(羊 COX-1 和 -2 的 Ki 值分别为 21 和 19 μM)。 | |||
T0637 |
2-Acetyl-6-methoxynaphthalene
|
Others | Others |
2-Acetyl-6-methoxynaphthalene 是naphthalene tome 和naproxen 的关键中间体,用于合成非甾体抗炎镇痛药。 | |||
T1867 |
Otenaproxesul
ATB 346 |
Apoptosis; COX | Apoptosis; Immunology/Inflammation; Neuroscience |
Otenaproxesul (ATB 346) 是一种具有口服活性的非甾体抗炎药,可抑制环氧合酶-1 和 2,具有抗炎生物活性,可用于缓解疼痛的研究。 | |||
T1350 |
4-Butoxyphenol
4-正丁氧基苯酚,P-Butoxyphenol |
Others | Others |
4-Butoxyphenol (P-Butoxyphenol) 是一种在科学和工业领域有广泛应用的酚类化合物。它经常用于合成其他化合物,如4-丁氧基苯乙酸和4-丁氧基苯乙腈;还用于合成药物,如布洛芬和萘普生。 | |||
T37176 | Edoxaban impurity 6 | ||
Edoxaban impurity 6 is an impurity of Edoxaban. Edoxaban (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with Kis of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and can be used for stroke prevention[1][2]. [1]. Furugohri T, et al. DU-176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles. J Thromb Haemost. 2008 Sep;6(9):1542-9.[2]. Mendell J, Lee F, Chen S, The Effe... |