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Search Results for " nk2 "
Targets Recommended: JNK

40

抑制剂 & 化合物

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Cat. No. Product Name Target Signaling Pathways
T78829 JNK2-IN-1

JNK MAPK
JNK2-IN-1（Compound J27）是一款具有抗炎活性的JNK2抑制剂，其解离常数为79.2 μM。该化合物能通过阻断NF-κB/MAPK信号通路来降低肿瘤坏死因子α（TNF-α）和白细胞介素6（IL-6）的释放，从而减轻脂多糖（LPS）引起的急性肺损伤（ALI）及脓毒症症状。
T62164 TNK2-IN-1

TNK2-IN-1 是一种 TNK2 抑制剂 (IC50: 224 nM)，能够用于研究癌症。
TP1772L Hemokinin 1 (mouse) acetate(208041-90-1 free base)

Neurokinin receptor GPCR/G Protein; Neuroscience
Hemokinin 1 (mouse) acetate(208041-90-1 free base) 是一种选择性兴奋剂 1 受体激动剂，对人 NK1 受体的 Ki 值为 0.175 nM，对人 NK2 受体的 Ki 值为 560 nM。
TP1385 Neurokinin A(4-10) TFA(97559-35-8 free base)

Neurokinin A(4-10) TFA

 Neurokinin receptor GPCR/G Protein; Neuroscience
Neurokinin A(4-10) TFA(97559-35-8 free base) 是一种速激肽 NK2 受体激动剂。
TP1899L1 Hemokinin 1 (human) acetate(491851-53-7 free base)

Neurokinin receptor GPCR/G Protein; Neuroscience
Hemokinin 1 (human) acetate(491851-53-7 free base) 是一种内源性 P 物质同系物，是速激肽 NK1 受体的选择性激动剂（NK1、NK3 和 NK2 受体的 IC50 值分别为 1.8、370 和 480 nM）。在体外对 B 细胞具有增殖和抗凋亡作用，在体内具有抗高血压作用。
T20413L Spantide acetate

Spantide acetate(91224-37-2 Free base)

 Neurokinin receptor GPCR/G Protein; Neuroscience
Spantide acetate 是 NK1 受体的特异性拮抗剂，对 NK1 和 NK2 的 Kis 分别为 230 nM 和 8150 nM。
TP1883 [Lys5,MeLeu9,Nle10]-NKA(4-10)

Neurokinin receptor GPCR/G Protein; Neuroscience
[Lys5,MeLeu9,Nle10]-NKA(4-10) 是高选择性和强效 NK2 受体激动剂，IC50值为 6.1 nM，可诱导大鼠眼底和膀胱收缩，EC50 值分别为 117 和 10 nM。
TP1086 Men 10376 TFA(135306-85-3,free)

Men 10376 TFA,Neurokinin-2 receptor antagonist TFA

 Neurokinin receptor GPCR/G Protein; Neuroscience
Men 10376 TFA(135306-85-3,free) (Neurokinin-2 receptor antagonist TFA) 是一种有效的选择性速激肽 nk-2 受体拮抗剂，对大鼠小肠 nk-2 受体的 K I 值为 4.4 M。
T16039 Ibodutant

MEN 15596

 Others Others
Ibodutant is an effective and selective tachykinin NK2 receptor antagonist (pKi: 10.1).
T15415 GR 159897

Others Others
GR 159897 is a competitive, brain-penetrated non-peptide NK2 receptor antagonist with anti-tumor effects. GR 159897 inhibits binding of [3H]GR100679 to human NK2-CHO cells and rat colon membranes (pKis: 9.51 and 10, respectively). It can antagonize bronch
T22811 GR 94800

Others Others
Potent and selective tachykinin NK2 receptor antagonist
T16842 Saredutant

SR 48968C,SR 48968

 Others Others
Saredutant is an antagonist of selective NK2 receptors.
T25459 GR 100679

GR100679,GR-100679
GR 100679 is an antagonist of NK2 receptor.
T7559 Neurokinin A(4-10)

神经激肽 A (4-10),Neurokinin A(4-10)(TFA)

 Neurokinin receptor GPCR/G Protein; Neuroscience
Neurokinin A(4-10) 是一种速激肽NK2受体激动剂。
T25197 Bz-Dab(nbd)-awfpp-nle-NH2

Bz-Dab(nbd)-ala-trp-phe-pro-pro-nle-NH2
Bz-Dab(nbd)-ala-trp-phe-pro-pro-nle-NH2 is a fluorescent NK2 antagonist.
T70432 MEN-10627

MEN-10627 is a polycyclic peptide and tachykinin NK2 receptor antagonist.
T70528 GR-112000

GR-112000 is a peptide-based tachykinin NK2 receptor antagonist.
T69295 DNK 333

DNK 333 is a dual neurokinin NK1/NK2 receptor antagonist.
T71935 WIN 66306

WIN 66306 is a cyclic heptapeptide antagonist of neurokinin-1 (NK1) and NK2 receptors originally isolated from A. flavipes. It binds to NK1 and NK2 receptors and inhibits contractions induced by substance P in isolated guinea pig ileum in a concentration-dependent manner.
T10892 CS-003 Free base

Neurokinin receptor GPCR/G Protein; Neuroscience
CS-003 free base (CS-003) is a triple tachykinin receptor antagonist with high affinity for human (neurokinin) NK1, NK2 and NK3 receptors, with Ki values of 2.3 nM and 0.54 nM, respectively And 0.74 nM. CS-003 free base (CS-003) has therapeutic effects on
T75882 [Lys5,MeLeu9,Nle10]-NKA(4-10) TFA

[Lys5,MeLeu9,Nle10]-NKA(4-10) TFA 是具有高度选择性的 NK2受体激动剂，其 IC50值为 6.1 nM。
TP1177 Eledoisin

Eledone peptide,依来多辛

 Neurokinin receptor GPCR/G Protein; Neuroscience
Eledoisin (Eledone peptide) 是一种特异性的NK2和NK3受体的激动剂。
TP1998 MDL 29913

MDL 29,913
NK2 tachykinin receptor selective antagonist.
T22811L GR 94800 acetate

GR 94800 acetate (141636-65-9 free base)

 Neurokinin receptor GPCR/G Protein; Neuroscience
GR 94800 acetate 是一种有效的选择性神经激肽 2(NK-2) 拮抗剂。
T76430 GR 87389

GR 87389 是一种有效的NK2受体拮抗剂。GR 87389 以竞争性方式拮抗 GA 64349 诱导的人类逼尿肌、前列腺和前列腺尿道平滑肌条收缩。
TP1100 [bAla8]-Neurokinin A(4-10)

MEN 10210
[bAla8]-Neurokinin A(4-10) is a neurokinin 2 (NK2) receptor agonist.
T23316 SB 218795

Neurokinin receptor GPCR/G Protein; Neuroscience
SB 218795 是一种有效的特异性 NK3 拮抗剂，对 hNK3 的 Ki 为 13 nM，比 hNK2 和 hNK1 的特异性高约 90 倍和 7000 倍。
TP1772 Hemokinin 1 (mouse)

Hemokinin 1 (mouse) is a selective excitogen 1 receptor agonist with a Ki value of 0.175 nM for the human NK1 receptor and 560 nM for the human NK2 receptor.
T75881 GR 64349 TFA

GR 64349为一种有效且高度选择性的神经激肽 2(NK2)受体肽类拮抗剂，具有在大鼠结肠中的EC50值仅为3.7 nM。相较于NK1和NK3受体，GR 64349展现出超过1000倍与300倍的选择性差异。
TP2023 GR 64349

Potent and selective tachykinin NK2 receptor agonist (EC50 = 3.7 nM in rat colon). Displays > 1000- and > 300-fold selectivity over NK1 and NK3 receptors respectively. Active in vivo.
T75840 Hemokinin 1, human TFA

Hemokinin 1, human TFA 是选择性的速激肽神经激肽 1 (NK1) 受体完全激动剂。Hemokinin 1, human TFA 也是 NK2和 NK3受体的完全激动剂。Hemokinin 1, human TFA 可以产生非阿片样物质的缓解疼痛作用。
TP1899 Hemokinin 1, human

Hemokinin 1 (human)
Endogenous substance P homolog that is a selective agonist at the tachykinin NK1 receptor (IC50 values are 1.8, 370 and 480 nM for NK1, NK3 and NK2 receptors respectively). Has proliferative and antiapoptotic actions on B-cells in vitro and is antihyperte
T75880 GR 94800 TFA

GR 94800 TFA 是有效的、选择性的神经激肽 2(NK2)受体的肽类拮抗剂，其对 NK2、NK1和 NK3受体的 pKB 值分别为 9.6、6.4 和 6.0。
T75742 Neurokinin A(4-10) TFA

Neurokinin A (4-10) TFA 是速激肽NK2受体激动剂。
T75837 Spantide I TFA

Spantide I TFA 是substance P 的类似物，是选择性的神经激肽-1 受体 (NK1receptor) 的拮抗剂，其对NK1和NK2受体的Ki 值分别为 230 nM 和8150 nM。Spantide I 可减少感染角膜的1型细胞因子和增强2型细胞因子IL-10，从而显著减少角膜穿孔。
T76426 [Lys5,MeLeu9,Nle10]Neurokinin A(4-10)

[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (LMN-NKA)，Neurokinin A 的类似物，是一种选择性且有效的 NK2R 激动剂。[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) 具有促运动活性。[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) 可用于研究 NK-2 受体在多种组织平滑肌收缩中的作用。
T71000 RO-5328673

RO-5328673 is a dual NK2/NK3 antagonist. O5328673. [(3)H]RO5328673 bound to a single saturable site on hNK2, hNK3 and gpNK3 with high-affinity. RO5328673 acted as an insurmountable antagonist at both human and guinea-pig NK3 receptors in the [(3)H]IP accumulation assay. In binding kinetic analyses, [(3)H]RO5328673 had fast association and dissociation rates at hNK2 while it had a fast association rate and a remarkably slow dissociation rate at gp and hNK3. In electrophysiological recordings of g...
T70456 Nolpitantium Free Base

Nolpitantium Free Base is a highly selective nonpeptide antagonist of neurokinin-1 (NK1) receptor. Nolpitantium potently, selectively and competitively inhibited substance P binding to NK1 receptors from various animal species, including humans. In vitro, it was a potent antagonist in functional assays for NK1 receptors such as [Sar9, Met(O2)11]substance P-induced endothelium-dependent relaxation of rabbit pulmonary artery and contraction of guinea-pig ileum. Up to 1 mkM, Nolpitantium had no eff...
T20413 Spantide I

Spantide
Spantide antagonizes both bombesin & substance P. It is also tachykinin receptor antagonist.
T16038 Men 10376

Neurokinin-2 receptor antagonist

 CDK Cell Cycle/Checkpoint
Men 10376 is a selective antagonist of tachykinin NK-2 receptor. It has a Ki of 4.4 μM for rat small intestine NK-2 receptor.

化合物

JNK2-IN-1
Cat.No: T78829
Synonym:
Target: JNK
TNK2-IN-1
Cat.No: T62164
Synonym:
Target:
Hemokinin 1 (mouse) acetate(208041-90-1 free base)
Cat.No: TP1772L
Synonym:
Target: Neurokinin receptor
Neurokinin A(4-10) TFA(97559-35-8 free base)
Cat.No: TP1385
Synonym: Neurokinin A(4-10) TFA
Target: Neurokinin receptor
Hemokinin 1 (human) acetate(491851-53-7 free base)
Cat.No: TP1899L1
Synonym:
Target: Neurokinin receptor
Spantide acetate
Cat.No: T20413L
Synonym: Spantide acetate(91224-37-2 Free base)
Target: Neurokinin receptor
[Lys5,MeLeu9,Nle10]-NKA(4-10)
Cat.No: TP1883
Synonym:
Target: Neurokinin receptor
Men 10376 TFA(135306-85-3,free)
Cat.No: TP1086
Synonym: Men 10376 TFA,Neurokinin-2 receptor antagonist TFA
Target: Neurokinin receptor
Ibodutant
Cat.No: T16039
Synonym: MEN 15596
Target: Others
GR 159897
Cat.No: T15415
Synonym:
Target: Others
GR 94800
Cat.No: T22811
Synonym:
Target: Others
Saredutant
Cat.No: T16842
Synonym: SR 48968C,SR 48968
Target: Others
GR 100679
Cat.No: T25459
Synonym: GR100679,GR-100679
Target:
Neurokinin A(4-10)
Cat.No: T7559
Synonym: 神经激肽 A (4-10),Neurokinin A(4-10)(TFA)
Target: Neurokinin receptor
Bz-Dab(nbd)-awfpp-nle-NH2
Cat.No: T25197
Synonym: Bz-Dab(nbd)-ala-trp-phe-pro-pro-nle-NH2
Target:
MEN-10627
Cat.No: T70432
Synonym:
Target:
GR-112000
Cat.No: T70528
Synonym:
Target:
DNK 333
Cat.No: T69295
Synonym:
Target:
WIN 66306
Cat.No: T71935
Synonym:
Target:
CS-003 Free base
Cat.No: T10892
Synonym:
Target: Neurokinin receptor
[Lys5,MeLeu9,Nle10]-NKA(4-10) TFA
Cat.No: T75882
Synonym:
Target:
Eledoisin
Cat.No: TP1177
Synonym: Eledone peptide,依来多辛
Target: Neurokinin receptor
MDL 29913
Cat.No: TP1998
Synonym: MDL 29,913
Target:
GR 94800 acetate
Cat.No: T22811L
Synonym: GR 94800 acetate (141636-65-9 free base)
Target: Neurokinin receptor
GR 87389
Cat.No: T76430
Synonym:
Target:
[bAla8]-Neurokinin A(4-10)
Cat.No: TP1100
Synonym: MEN 10210
Target:
SB 218795
Cat.No: T23316
Synonym:
Target: Neurokinin receptor
Hemokinin 1 (mouse)
Cat.No: TP1772
Synonym:
Target:
GR 64349 TFA
Cat.No: T75881
Synonym:
Target:
GR 64349
Cat.No: TP2023
Synonym:
Target:
Hemokinin 1, human TFA
Cat.No: T75840
Synonym:
Target:
Hemokinin 1, human
Cat.No: TP1899
Synonym: Hemokinin 1 (human)
Target:
GR 94800 TFA
Cat.No: T75880
Synonym:
Target:
Neurokinin A(4-10) TFA
Cat.No: T75742
Synonym:
Target:
Spantide I TFA
Cat.No: T75837
Synonym:
Target:
[Lys5,MeLeu9,Nle10]Neurokinin A(4-10)
Cat.No: T76426
Synonym:
Target:
RO-5328673
Cat.No: T71000
Synonym:
Target:
Nolpitantium Free Base
Cat.No: T70456
Synonym:
Target:
Spantide I
Cat.No: T20413
Synonym: Spantide
Target:
Men 10376
Cat.No: T16038
Synonym: Neurokinin-2 receptor antagonist
Target: CDK
Species：
Human (5)
Mouse (5)
Expression System：
Baculovirus Insect Cells (6)
HEK293 Cells (3)
E. coli (1)
Tag：
Tag Free (3)
C-His (2)
His, GST (2)
C-hFc (1)
N-10xHis, C-Myc (1)
N-GST (1)
Cat. No. Product Name Species Expression System
TMPY-03290 HGF Protein, Mouse, Recombinant

hepatocyte growth factor (hepapoietin A,NK1,scatter...

 Mouse HEK293 Cells
HGF Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 79.3 kDa and the accession number is Q08048-1.
TMPY-03237 HGF Protein, Mouse, Recombinant (His)

SF/HGF,hepatocyte growth factor (hepapoietin A,肝细胞生长因子,N...

 Mouse HEK293 Cells
HGF Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 80.8 kDa and the accession number is Q08048-1.
TMPY-04750 CSNK2A2 Protein, Human, Recombinant

CK2A2,CSNK2A1,casein kin...

 Human Baculovirus Insect Cells
CSNK2A2 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 41.4 kDa and the accession number is P19784.
TMPY-04758 CK2 alpha/CSNK2A1 Protein, Mouse, Recombinant

casein kinase 2, α1 polypeptide,casein kinase 2...

 Mouse Baculovirus Insect Cells
CK2 alpha/CSNK2A1 Protein, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 45.3 kDa and the accession number is Q60737.
TMPY-04393 CSNK2A2 Protein, Human, Recombinant (His & GST)

casein kinase 2, alpha prime polypeptide,CK2

Human Baculovirus Insect Cells
CSNK2A2 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 69 kDa and the accession number is P19784.
TMPH-02898 SPINK2 Protein, Mouse, Recombinant (His & Myc)

Mouse E. coli
As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects. May be involved in the regulation of serine protease-dependent germ cell apoptosis. It also inhibits trypsin. SPINK2 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 15.0 kDa and ...
TMPY-00163 SPINK2 Protein, Human, Recombinant (hFc)

serine peptidase inhibitor, Kazal type 2 (acrosin-t...

 Human HEK293 Cells
Human serine proteinase inhibitor Kazal-type 2 (SPINK2) functions as a trypsin/acrosin inhibitor and is synthesized mainly in the testis and seminal vesicle where its activity is engaged in fertility. The SPINK2 protein contains a typical Kazal domain composed by six cysteine residues forming three disulfide bridges. The expression of SPINK2 is closely related to cancer such as lymphomas, in that a high transcript level of SPINK2 in patients with primary cutaneous follicle center cell lymphomas ...
TMPY-04441 CK2 alpha/CSNK2A1 Protein, Mouse, Recombinant (His & GST)

casein kinase 2, alpha 1 polypeptide,casein kinase ...

 Mouse Baculovirus Insect Cells
CK2 alpha/CSNK2A1 Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 72.9 kDa and the accession number is Q60737.
TMPY-04372 CK2 alpha/CSNK2A1 Protein, Human, Recombinant (GST)

CK2 α/CSNK2A1,CKII,CSNK<...

 Human Baculovirus Insect Cells
CK2 alpha/CSNK2A1 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 71.4 kDa and the accession number is P68400-1.
TMPY-04550 JNK2 Protein, Human, Recombinant (His)

JNK2α,SAPK1a,PRKM9,JNK2β...

 Human Baculovirus Insect Cells
Mitogen-activated protein kinase 9 (MAPK9), also well known as c-Jun N-terminal kinase (JNK2), is a member of the MAP kinase subfamily belonging to the protein kinase superfamily. MAPK9 responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating some transcription factors, such as c-Jun and ATF2. The crystal structure of human JNK2 complexed with an indazole inhibitor by applying a high-throughput protein engineering and surface-site mutagenesis approach. A n...

重组蛋白

HGF Protein, Mouse, Recombinant
Cat.No: TMPY-03290
Species: Mouse
Expression System: HEK293 Cells
HGF Protein, Mouse, Recombinant (His)
Cat.No: TMPY-03237
Species: Mouse
Expression System: HEK293 Cells
CSNK2A2 Protein, Human, Recombinant
Cat.No: TMPY-04750
Species: Human
Expression System: Baculovirus Insect Cells
CK2 alpha/CSNK2A1 Protein, Mouse, Recombinant
Cat.No: TMPY-04758
Species: Mouse
Expression System: Baculovirus Insect Cells
CSNK2A2 Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-04393
Species: Human
Expression System: Baculovirus Insect Cells
SPINK2 Protein, Mouse, Recombinant (His & Myc)
Cat.No: TMPH-02898
Species: Mouse
Expression System: E. coli
SPINK2 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-00163
Species: Human
Expression System: HEK293 Cells
CK2 alpha/CSNK2A1 Protein, Mouse, Recombinant (His & GST)
Cat.No: TMPY-04441
Species: Mouse
Expression System: Baculovirus Insect Cells
CK2 alpha/CSNK2A1 Protein, Human, Recombinant (GST)
Cat.No: TMPY-04372
Species: Human
Expression System: Baculovirus Insect Cells
JNK2 Protein, Human, Recombinant (His)
Cat.No: TMPY-04550
Species: Human
Expression System: Baculovirus Insect Cells
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