Cat. No. | Product Name | Target | Signaling Pathways |
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T63377 |
Moexipril
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Moexipril 是口服具有活力的血管紧张素转换酶 (ACE) 抑制剂。Moexipril 易于透过脂质膜,靶向血浆和组织ACE,改善内皮功能障碍,具有神经保护活性,能够用于研究心血管疾病。 | |||
T6595 |
Moexipril hydrochloride
莫昔普利盐酸盐,Moexipril HCl,RS-10085,SPM 925,CI-925 |
Apoptosis; RAAS | Apoptosis; Endocrinology/Hormones |
Moexipril hydrochloride (Moexipril HCl) 是一种有口服活性的,不含巯基的血管紧张素转化酶抑制剂,可治疗高血压和充血性心力衰竭。 | |||
T71555 |
Moexipril ethyl ester
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Moexipril ethyl ester is a long-acting, non-sulfhydryl angiotensine-converting enzyme inhibitor. | |||
T70884 | Moexipril methyl ester | ||
Moexipril methyl ester is a long-acting, non-sulfhydryl angiotensine-converting enzyme inhibitor. | |||
T70883 |
Moexipril-d5
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Moexipril-d5 intended for use as an internal standard for the quantification of moexipril by GC- or LC-MS. Moexipril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor moexiprilat. It is converted to moexiprilat in vivo by side chain ester hydrolysis. Moexipril inhibits ACE in a cell-free assay (IC50 = 2.7 µM for the rabbit enzyme). It also inhibits phosphodiesterase 4 (IC50s = 38, 160, and 230 µM for PDE4B2, PDE4A5 and PDE4D5, respectively). Moexipril (0.1-30 mg/kg per day) ... | |||
T70881 | Dolutegravir RR Isomer | ||
Dolutegravir RR Isomer is an isomer of Dolutegravir -- a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector. | |||
T83766 |
Moexiprilat
RS 10029 |
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Moexiprilat是一种血管紧张素转换酶(ACE; IC50 = 2.1 nM)的抑制剂,也是前药moexipril的一种活性代谢产物。通过侧链酯水解作用,在体内从moexipril转化而来。Moexiprilat (10 nM)能防止初生大鼠心脏成纤维细胞在雌激素或血管紧张素II刺激下的增殖。在以每天50 mg/kg剂量给药的去卵巢小鼠中,降低平均动脉血压,并增加心房钠尿肽水平,这是高血压的一个标志。 | |||
T1689 |
Enalapril IMpurity B
(+)-N-[1-(S)-Ethoxycarbonxyl-3-phenylpropyl]-L-alanine,依那普利杂质B |
Others | Others |
Enalapril IMpurity B ((+)-N-[1-(S)-Ethoxycarbonxyl-3-phenylpropyl]-L-alanine) 是 Moexipril 中间体,是 Imidapril 的主要代谢物。 |