Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T61303 |
MmpL3-IN-1
|
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MmpL3-IN-1, also known as compound 32, is a highly effective inhibitor of Mycobacterial membrane protein large 3 (MmpL3). With an anti-tuberculosis activity exhibiting a minimum inhibitory concentration (MIC) of less than 0.016 μg/mL in M. tuberculosis, MmpL3-IN-1 is a valuable compound for research on drug-resistant tuberculosis [1]. | |||
T78786 | MmpL3-IN-3 | ||
MmpL3-IN-3 (Compound 12) 为一种MmpL3抑制剂,对 H37Rv 的最小抑制浓度(MIC)为 0.1 μM。该化合物在小鼠肝微粒体中具有良好稳定性,适用于抗结核研究。 | |||
T79291 | MmpL3-IN-2 | ||
MmpL3-IN-2为一种具备中等代谢稳定性和较低细胞毒性的MmpL3抑制剂,适用于结核病研究。 | |||
T7342 |
BM212
|
Antibacterial | Microbiology/Virology |
BM212 是一种分枝杆菌膜蛋白 MmpL3抑制剂。它抑制结核分枝杆菌和部分非结核分枝杆菌,抗结核杆菌 H37Rv 菌株的 MIC 值为 5 µM。 | |||
T8411 |
C-215
|
Others | Others |
C-215 是MmpL3抑制剂。它在 HTS 中被鉴定为对结核分枝杆菌具有独立的甘油活性,对哺乳动物细胞的非特异性毒性较低,对结核分枝杆菌的IC90=16 μM,并且能够有效抑制在巨噬细胞中生长的结核分枝杆菌。 | |||
T10411 |
AU1235
|
Antibacterial | Microbiology/Virology |
AU1235是金刚烷脲,是一种MmpL3抑制剂。结核分枝杆菌蛋白MmpL3在细胞壁合成中起重要作用,它影响海藻糖单支霉菌酸酯跨内膜转运。 | |||
T16925 |
SQ109
NSC 722041 |
Others; Parasite | Microbiology/Virology; Others |
SQ109 (NSC-722041) 是一种有效的锥鞭毛体形式的寄生虫抑制剂 (IC50 = 50 nM)。 SQ109 是一种抗结核药物,靶向 MmpL3。 | |||
T12231 |
NITD-349
|
Others; Antibacterial | Microbiology/Virology; Others |
NITD-349 是MmpL3的抑制剂,它对毒性结核分枝杆菌 H37Rv 显示出高效的抗分枝杆菌活性,MIC50 为 23 nM。 | |||
T27477 | GSK366A | ||
GSK366A is an anti-TB agent against Mycobacterium bovis BCG and Mycobacterium tuberculosis, targeting MmpL3 and inhibiting EchA6. | |||
T70671 |
IC2418
|
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IC2418 is an MmpL3 inhibitor, being active against drug-resistant Mycobacterium tuberculosis. | |||
T10563L2 |
BM635 mesylate (1493762-74-5 free base)
BM635 mesylate |
Others | Others |
BM635 mesylate is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv). | |||
T10563 | BM635 | Others | Others |
BM635 is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv). | |||
T10563L |
BM635 hydrochloride (1493762-74-5 free base)
BM635 hydrochloride |
Others | Others |
BM635 hydrochloride is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv). | |||
T62358 | BM635 hydrochloride | ||
BM635 hydrochloride 是一种 MmpL3 抑制剂,表现出显著的抗分歧杆菌效果,能够抑制结合分歧杆菌 H37Rv (MIC50: 0.08 μM)。与游离 BM635 相比,BM635 hydrochloride 在体内暴露量提高了一倍。 | |||
T63263 | BM635 mesylate | ||
BM635 mesylate 是一种 MmpL3 的抑制剂,表现出明显的抗分歧杆菌作用,抑制和结合分歧杆菌 H37Rv 的 MIC50值为 0.6 μM。与游离态 BM635 相比,BM635 mesylate 能够明显提高生物利用度。 |