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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T18230	MAC glucuronide linker-1	Others	Others
	MAC glucuronide linker-1 is a nonclaevable ADC linker for antibody-drug-conjugations (ADCs).
T3638	Leukadherin-1	Integrin; Complement System	Cytoskeletal Signaling; Immunology/Inflammation
	Leukadherin-1 是 CD11b/CD18 的变构激活剂，可增加 CD11b/CD18 依赖性细胞对纤维蛋白原的粘附，减少白细胞运动和跨内皮迁移，具有抗炎作用。
T76844	Abciximab C7E3	Integrin	Cytoskeletal Signaling
	Abciximab (C7E3) 是一种小鼠/人嵌合单克隆抗体，是一种有效的糖蛋白 IIb/IIIa (glycoprotein IIb/IIIa) 抑制剂。 Abciximab 具有抗血小板聚集和白细胞粘附的作用，通过与糖蛋白 IIb/IIIa、vitronectin 和 Mac-1 受体结合发挥作用。
T67749	Fuzapladib IS-741	Phospholipase	Metabolism
	Fuzapladib (IS-741) (IS-741)是一种磷脂酶A2抑制剂，可以抑制细胞粘附分子Mac-1的表达。fuzpladib 阻断炎症细胞表面表达的粘附分子(integrin)的激活，阻止炎症细胞粘附血管内皮细胞和浸润组织，控制胰腺炎的恶化。
T10863	Complement C5-IN-1	Complement System	Immunology/Inflammation
	Complement C5-IN-1 (Compound 7) 是补体成分蛋白5 (C5) 的小分子抑制剂。 Complement C5-IN-1 与 C5 相互作用以防止其被 C5 转化酶切割, 阻断酵母多糖诱导的 50％人全血 MAC 沉积的 IC50 值为 0.77 μM。
T18538	MAC glucuronide phenol-linked SN-38	Others	Others
	MAC glucuronide phenol-linked SN-38, a pH-sensitive lactone and DNA topoisomerase I inhibitor drug linker, exhibits cytotoxicity in L540cy and Ramos cells, with IC50 values of 113 ng/mL and 67 ng/mL, respectively[1].
T18721	MAC-VC-PABC-ST7612AA1	Others	Others
	MAC-VC-PABC-ST7612AA1 is a part of antibody drug conjugates (ADCs) charged with HDAC inhibitor by a linker, shows antitumor activity[1].
T24207	JNJ-28610244 JNJ 28610244
	JNJ-28610244 is a specific agonist of the H4 receptor. It acts by blocking Mac-1-dependent activation of p38 MAPK.
T18231	MAC glucuronide linker-2	Others	Others
	MAC glucuronide linker-2 is an ADC linker employed in the synthesis of ADCs, offering cleavability [1].
T22202	iMAC2
	iMAC2 是一种有效的MAC 抑制剂，IC50为 28 nM，LD50为15000 nM。iMAC2 显示出抗凋亡作用，并且iMAC2 阻断细胞色素 c 的释放。
T18722	MAC glucuronide α-hydroxy lactone-linked SN-38	Others	Others
	MAC glucuronide α-hydroxy lactone-linked SN-38 (Topoisomerase I inhibitor) is a stabilized lactone MAC glucuronide α-hydroxy lactone-linked SN-38 drug linker. MAC glucuronide α-hydroxy lactone-linked SN-38 is cytotoxic across L540cy cells and Ramos cells
T16898	Complement factor D-IN-1	Others	Others
	Complement factor D-IN-1 is an effective and selective small-molecule reversible factor d inhibitor (IC50s: 0.006 and 0.05 μM in FD Thioesterolytic Fluorescent Assay and a MAC Deposition Assay, respectively).
T80682	γ-Fibrinogen 377-395 TFA
	γ-Fibrinogen377-395 TFA 是纤维蛋白原衍生抑制肽，具有纤维蛋白原表位特性。该化合物能在体外抑制小胶质细胞激活、阻断纤维蛋白与Mac-1相互作用，并在小鼠体内抑制实验性自身免疫性脑脊髓炎(EAE)。该肽适用于多发性硬化症(MS)及其他血脑屏障损伤和小胶质细胞激活相关的神经炎症疾病研究。
T80683	γ-Fibrinogen 377-395
	γ-Fibrinogen377-395是一种衍自纤维蛋白原的抑制性肽段，也被认为是纤维蛋白原的表位之一。它能在体外抑制小胶质细胞的激活并阻断纤维蛋白与Mac-1的交互作用；此外，在小鼠体内能够抑制实验性自身免疫性脑脊髓炎(EAE)的发展。因此，γ-Fibrinogen377-395对于多发性硬化症(MS)以及其他与血脑屏障损伤和小胶质细胞活化相关的神经炎症性疾病的研究具有潜在的应用价值。
T38309	LL-37 amide (trifluoroacetate salt)
	LL-37 is a cationic and α-helical antimicrobial peptide expressed in human bone marrow, testis, granulocytes, and gingival epithelium and is upregulated in psoriatic lesions. It inhibits growth of Gram-positive E. coli D21 and Gram-negative B. megatarium in a concentration-dependent manner and LL-37 expression is induced in A549 epithelial cells, alveolar macrophages, neutrophils, and monocyte-derived macrophages following M. tuberculosis infection. LL-37 binds sheep erythrocytes coated with S. ...
T71212	Lornoxicam-d4
	Lornoxicam-d4 is intended for use as an internal standard for the quantification of lornoxicam by GC- or LC-MS. Lornoxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. It inhibits production of thromboxane B2 from arachidonic acid in HEL human erythroleukemic cells, which endogenously express COX-1, as well as inhibits LPS-induced formation of prostaglandin F1α from arachidonic acid in Mono-Mac-6 cells, which endogenously e...

化合物

MAC glucuronide linker-1

Cat.No: T18230

Target: Others

Cat.No: T3638

Target: Integrin, Complement System

Cat.No: T76844

Synonym: C7E3

Target: Integrin

Cat.No: T67749

Synonym: IS-741

Target: Phospholipase

Complement C5-IN-1

Cat.No: T10863

Target: Complement System

MAC glucuronide phenol-linked SN-38

Cat.No: T18538

Target: Others

MAC-VC-PABC-ST7612AA1

Cat.No: T18721

Target: Others

Cat.No: T24207

Synonym: JNJ 28610244

MAC glucuronide linker-2

Cat.No: T18231

Target: Others

Cat.No: T22202

MAC glucuronide α-hydroxy lactone-linked SN-38

Cat.No: T18722

Target: Others

Complement factor D-IN-1

Cat.No: T16898

Target: Others

γ-Fibrinogen 377-395 TFA

Cat.No: T80682

γ-Fibrinogen 377-395

Cat.No: T80683

LL-37 amide (trifluoroacetate salt)

Cat.No: T38309

Cat.No: T71212

Cat. No.	Product Name	Target	Signaling Pathways
TN1966	N-(3-Methoxybenzyl)Oleamide N-Benzyloleamide,MAC 18:1	Antioxidant	oxidation-reduction
	N-(3-Methoxybenzyl)Oleamide (MAC 18:1) 是一种从 Lepidium meyenii 中分离出来的玛瑙酰胺，对运动引起的疲劳具有药理作用，可能与调节能量代谢和改善抗氧化状态有关。

天然产物

N-(3-Methoxybenzyl)Oleamide

Cat.No: TN1966

Synonym: N-Benzyloleamide,MAC 18:1

Target: Antioxidant

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