5
3
Cat. No. | Product Name | Target | Signaling Pathways |
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TP1834 |
MUC5AC motif peptide
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MUC5AC motif peptide is a 16-amino acid fragment of mucin 5. | |||
T1481 |
Fudosteine
福多司坦,福多斯坦 |
Others | Others |
Fudosteine 是一种半胱氨酸衍生物和粘液活性剂。它能够抑制 MUC5AC 基因表达,阻碍 MUC5AC 粘蛋白过度分泌。 | |||
T77407 |
Ensituximab
NPC-1C,NEO-102,NEO-101 |
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Ensituximab (NEO-102) 是一种准对 MUC5AC 变体的选择性 IgG1 单克隆抗体,具有抗肿瘤活性,抑制结直肠癌和胰腺癌。 | |||
T71286 |
Guaifenesin-d3
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Guaifenesin-d3 is intended for use as an internal standard for the quantification of guaifenesin by GC- or LC-MS. Guaifenesin is an expectorant. It inhibits production of mucin 5AC (MUC5AC), reduces mucus viscosity and elasticity, and increases the mucociliary transport rate of endogenous particles in primary human tracheobronchial epithelial cells in a concentration-dependent manner. Guaifenesin increases phenol red secretion, a marker of expectorant activity, in rats.3 Formulations containing ... | |||
T71143 | Ambroxol-d5 | ||
Ambroxol-d5 is intended for use as an internal standard for the quantification of ambroxol by GC- or LC-MS. Ambroxol is an expectorant and active metabolite of bromhexine. It decreases short-circuit currents in electrically stimulated isolated canine tracheal epithelial cells when applied submucosally. Ambroxol decreases IL-13-induced production of mucin 5AC (MUC5AC) in primary human airway epithelial cells and inhibits IL-13-induced decreases in the mucociliary transport rate of endogenous part... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T4S0969 |
Obtusifolin
决明蒽醌,决明蒽醌;美决明子素 |
Antioxidant; NF-κB | NF-κB; oxidation-reduction |
Obtusifolin 是分离自决明子的种子中,能够抑制NF-kB 通路,调节气道上皮细胞中 MUC5AC 粘蛋白的基因表达和产生。它通过靶向甲状旁腺激素相关蛋白来抑制邻苯二甲酸酯诱导的乳腺癌骨转移。 | |||
T4S0878 |
Prunetin
樱黄素,Prunusetin |
ERK; Dehydrogenase; NF-κB | MAPK; Metabolism; NF-κB |
Prunetin (Prunusetin) 是一种O-甲基化异黄酮,具有抗炎的作用。它是人醛脱氢酶的有效抑制剂。 | |||
TN1848 |
Kuwanon E
桑黄酮 E,桑皮酮 E,5'-[(E)-3,7-二甲基-2,6-辛二烯基]-2',4',5,7-四羟基黄烷酮 |
AChR | Neuroscience |
Kuwanon E inhibited cholinesterase enzyme in a dose-dependent manner with K i values ranging between 3.1 and 37.5 μM and between 1.7 and 19.1 μM against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes, respectively. Kuwanon E also inh |